Results 101 to 110 of about 26,660 (305)
Advanced Intelligent Systems, EarlyView.This paper introduces an origami‐inspired, lightweight, reconfigurable instrument for robot‐assisted minimally invasive surgery. Its foldable design enables tiny access, tunable compliance, and multifunctionality, serving as a tool introducer or deformable grasper that safely manipulates delicate bowel tissue.
Lorenzo Mocellin +5 more
wiley +1 more source
Frontiers in PharmacologyAccurately identifying novel indications for drugs is crucial in drug research and discovery. Traditional drug discovery is costly and time-consuming.
Huimin Luo +11 more
doaj +1 more source
Semi‐autonomous Navigation of Magnetic Microcarriers for Knee Cartilage Regeneration
Advanced Intelligent Systems, EarlyView.Autonomous navigation of magnetic microcarriers in complex 3D environments is investigated through a semi‐autonomous strategy integrating magnetic actuation with monocular visual feedback. Real‐time global tracking is achieved via radio‐frequency‐based localization and depth estimation, while model‐based computation determines optimal steering forces ...
Kim Tien Nguyen +3 more
wiley +1 more source
Severe, Non‐apneic Respiratory Dysfunction and Hypoxia following Generalized Convulsive Seizures
Annals of Neurology, EarlyView.Objective Sudden unexpected death in epilepsy (SUDEP) is a devastating consequence of some generalized convulsive seizures (GCS). Recent work has focused on seizure related apnea as a biomarker of SUDEP risk, frequently without characterizing the adequacy of non‐apneic ventilation or identifying other dysfunctional breathing patterns.
Haley E. Pysick +9 more
wiley +1 more source
Old friends in new guise: repositioning of known drugs with structural bioinformatics [PDF]
, 2011 V. Joachim Haupt, Michael Schroeder
openalex +1 more source
Annals of Neurology, EarlyView.Objective Heightened sensitivity to noxious stimulation is a hallmark of chronic pain. Emerging evidence suggests heightened unpleasantness to non‐noxious (eg, auditory) aversive stimulation also characterizes chronic pain, but its magnitude, neural mechanisms, and treatment modifiability remain unknown.
Alina E. C. Panzel +4 more
wiley +1 more source
Accurate Drug Repositioning through Non-tissue-Specific Core Signatures from Cancer Transcriptomes
Cell Reports, 2018 Summary: Experimental large-scale screens for drug repositioning are limited by restriction to in vitro conditions and lack of applicability to real human conditions. Here, we developed an in silico screen in human in vivo conditions using a reference of
Chi Xu +11 more
doaj +1 more source
Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury
British Journal of Clinical Pharmacology, EarlyView.Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra +8 more
wiley +1 more source
Sitravatinib enhances doxorubicin cytotoxicity in doxorubicin‐resistant K562/ADM cells
Bulletin of the Korean Chemical Society, EarlyView.A repositioning‐based screening identified sitravatinib that synergistically enhances doxorubicin efficacy in doxorubicin‐resistant leukemia cells. Abstract Drug resistance remains a major obstacle in leukemia treatment, and combination therapy has emerged as an effective strategy to overcome this limitation. This study aimed to identify compounds with
Min Jeong Ahn +3 more
wiley +1 more source
Drug Repositioning and Subgroup Discovery for Precision Medicine Implementation in Triple Negative Breast Cancer [PDF]
, 2021 Zainab Al-Taie +4 more
openalex +1 more source