Breaking the paradigm: Dr Insight empowers signature-free, enhanced drug repurposing [PDF]
, 2019 Motivation: Transcriptome-based computational drug repurposing has attracted considerable interest by bringing about faster and more cost-effective drug discovery.
Baldwin, Nicole E. +4 more
core +1 more source
Drug repositioning : a machine-learning approach through data integration [PDF]
, 2013 Existing computational methods for drug repositioning either rely only on the gene expression response of cell lines after treatment, or on drug-to-disease relationships, merging several information levels.
D'Amato, Mauro +6 more
core +1 more source
Drug repositioning for enzyme modulator based on human metabolite-likeness
BMC Bioinformatics, 2017 Background Recently, the metabolite-likeness of the drug space has emerged and has opened a new possibility for exploring human metabolite-like candidates in drug discovery.
Yoon Hyeok Lee +4 more
doaj +1 more source
Thiopurine Drugs Repositioned as Tyrosinase Inhibitors [PDF]
International Journal of Molecular Sciences, 2017 Drug repositioning is the application of the existing drugs to new uses and has the potential to reduce the time and cost required for the typical drug discovery process. In this study, we repositioned thiopurine drugs used for the treatment of acute leukaemia as new tyrosinase inhibitors.
Choi, Joonhyuck +2 more
openaire +2 more sources
Chromatin Topology Reconfiguration Orchestrates Thermotolerant Male Fertility via GhAL5 in Cotton
Advanced Science, EarlyView.This study investigates cotton’s high‐temperature (HT) response using multi‑omics. Dynamic 3D genome changes drive expression bias affecting male fertility. The tolerant line shows controlled chromatin dynamics, while the sensitive line exhibits overactivation.
Yanlong Li +15 more
wiley +1 more source
Paradigm shift in drug re-purposing from Phenalenone to Phenaleno-Furanone to combat multi-drug resistant Salmonella Enterica Serovar Typhi [PDF]
, 2018 Over recent years, typhoid fever has gained increasing attention with several cases reporting treatment failure due to multidrug resistant (MDR) strains of Salmonella enterica serovar Typhi.
Gatherer, Derek +2 more
core +7 more sources
Using the drug repositioning approach to develop a novel therapy, tipepidine hibenzate sustained-release tablet (TS-141), for children and adolescents with Attention-Deficit/Hyperactivity Disorder [PDF]
, 2020 Takuya Saito +10 more
openalex +2 more sources
Structure-based drug repositioning explains ibrutinib as VEGFR2 inhibitor.
PLoS ONE, 2020 Many drugs are promiscuous and bind to multiple targets. On the one hand, these targets may be linked to unwanted side effects, but on the other, they may achieve a combined desired effect (polypharmacology) or represent multiple diseases (drug ...
Melissa F Adasme +11 more
doaj +1 more source
Advanced Science, EarlyView.Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen +8 more
wiley +1 more source
Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells [PDF]
, 2011 Copyright @ 2011 Mehta et al.; licensee BioMed Central Ltd. This article has been made available through the Brunel Open Access Publishing Fund. This is an open access article distributed under the terms of the Creative Commons Attribution License ...
Arican, HD +4 more
core +2 more sources