Results 121 to 130 of about 26,660 (305)

In Vivo Cytoskeletal AMPA Receptor Transport Imaging in C. elegans

Cytoskeleton, EarlyView.
ABSTRACT Long‐distance intracellular transport of ionotropic glutamate receptors (iGluRs) is essential for proper excitatory synaptic function underlying learning and memory. Many neuropsychiatric and neurodegenerative conditions have abnormal iGluR transport and trafficking, leading to an intense interest in the mechanisms and factors regulating these
Michaelis A. K., Hoerndli F. J.
wiley   +1 more source

Drug repositioning for schistosomiasis

, 2014
Poster about the project in drug repositioning applied to schistosomiasis carried out at the London School of Hygiene and Tropical Medicine under the supervision of Dr Nick Furnham. Shows preliminary results obtained from the project.
openaire   +1 more source

Advancing Pharmacoequity Globally: Reflections from the ASCPT Development, Regulatory, and Outcomes Network

Clinical Pharmacology &Therapeutics, EarlyView.
ASCPT has a mission to advance clinical pharmacology and translational sciences to reduce health disparities. The development, regulatory, and outcomes (DRO) network within ASCPT strives to advance pharmacoequity globally. Pharmacoequity, coined by Utibe Essien (2021), is the principle that all individuals, regardless of race, ethnicity, geography, or ...
Priya Jayachandran, Mayur K. Ladumor, Georgios Vlasakakis, Andrew Riselli, Katarina V. Ilic, Rob C. van Wijk, Mohamed Elmeliegy, Jatinder Kaur Mukker, Aarti Sawant‐Basak, Tao Long, Juyao Dong, Noha Rayad, Tao Zhang, on behalf of the DRO Network   +13 more
wiley   +1 more source

Faculty Opinions recommendation of A review of validation strategies for computational drug repositioning.

, 2017
Ram Samudrala, Jim Schuler
openalex   +2 more sources

Advancing Pharmacometrics in Africa: Insights and Perspectives From the 2025 Pharmacometrics Africa Conference

Clinical Pharmacology &Therapeutics, EarlyView.
Pharmacometrics (PMX) in Africa has transitioned from foundational capacity‐building to job creation, scientific leadership, regulatory influence, and health innovation. To accelerate this progress, the 2025 Pharmacometrics Africa Conference (PMXAC‐2025) convened key stakeholders to consolidate the continental PMX community, review progress in local ...
Babatunde Ayodeji Adeagbo, Innocent Gerald Asiimwe, Linda Chaba, Aida N. Kawuma, Francis Williams Ojara, Ochuko Maureen Orherhe, Simon Peter Asiimwe, Veshni Pillay‐Fuentes Lorente, Sharon Sawe, Cassius M. Phogole, Catriona Waitt, Samer Mouksassi, Goonaseelan (Colin) Pillai   +12 more
wiley   +1 more source

Blood Immune Cell Composition Associated with Obesity and Drug Repositioning Revealed by Epigenetic and Transcriptomic Conjoint Analysis

, 2021
Jiachen Liu, Shenghua Liu, Guang Fu, Xiaorui Qiu, Rundong Jiang, Sheng-Yuan Huang, Liyong Zhu, Weizheng Li   +7 more
openalex   +1 more source

The role of Rho GTPases in facial morphogenesis

Developmental Dynamics, EarlyView.
The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley   +1 more source

Exploration of Potential Ewing Sarcoma Drugs from FDA-Approved Pharmaceuticals through Computational Drug Repositioning, Pharmacogenomics, Molecular Docking, and MD Simulation Studies

, 2022
Mubashir Hassan, Muhammad Yasir, Saba Shahzadi, Andrzej Kloczkowski   +3 more
openalex   +1 more source

Prospective evaluation of a seizure detection wearable device for timely interventions in an epilepsy monitoring unit

Epilepsia, EarlyView.
Abstract Objective This study aimed to evaluate the real‐world performance of a wrist‐worn seizure detection device for timely clinical interventions within an epilepsy monitoring unit (EMU). Methods We conducted a prospective observational study involving patients admitted to the EMU at a tertiary care center.
Amirhossein Jahani, Daniel Alejandro Galindo Lazo, Isabel Sarzo Wabi, Oumayma Gharbi, Manon Robert, Juan Pablo Millan, Gianluca D'onofrio, Alexis Robin, Dang K. Nguyen, Elie Bou Assi   +9 more
wiley   +1 more source

Spectral entropy variability of intraoperative electrocorticography predicts outcome after epilepsy surgery in people with focal cortical dysplasia

Epilepsia, EarlyView.
Abstract Objective Epilepsy surgery in people with focal cortical dysplasia (FCD) requires accurate removal of all epileptogenic tissue, and outcome is difficult to predict. We explored whether spectral entropy, a fast computable electroencephalographic (EEG) feature, could estimate epileptic activity in intraoperative electrocorticography (ioECoG) and
Eline V. Schaft, Sem Hoogteijling, Dongqing Sun, Cyrille H. Ferrier, Pieter van Eijsden, Wim M. Otte, Galia Anguelova, Nick F. Ramsey, Maryse A. van't Klooster, Maeike Zijlmans, on behalf of the RESPect database study group, Charlotte van Asch, Lydia van de Berg, Dorien van Blooijs, Kim Boshuisen, Mireille Bourez, Kees Braun, Jan Willem Dankbaar, Matteo Demuru, Pieter van Eijsden, Cyrille Ferrier, Tineke Gebbink, Fernando Gomez‐Acebo Ruiz, Peter Gosselaar, Kimberley Grasmeijer, Renate van Griethuysen, Jiaojiao Guo, Irene Heijink, Monique Hobbelink, Friso Hoefnagels, Sem Hoogteijling, Geertjan Huiskamp, Sarah Jacobs, Floor Jansen, Susanne Jelsma, Nicole van Klink, Merel Koopmans, Frans Leijten, Wouter Maathuis, Mariska Mantione, Angelika Muhlebner, Brechje Olgers, Janine van Ophorst, Miranda Postma, Sandra van der Salm, Eline Schaft, Anniek van Schaik, Monique van Schooneveld, Dongqing Sun, Ziyi Wang, Martine van Zandvoort, Eva Zuidhoek, Willemiek Zweiphenning, Jack Zwemmer   +53 more
wiley   +1 more source