Results 131 to 140 of about 59,924 (341)

The complexity of dementia development and its comorbidities: The collaborative cross‐mouse population for multivarious tasks approach

Animal Models and Experimental Medicine, EarlyView.
The increasing prevalence of dementia and related neurodegenerative diseases—including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis—poses a growing public health challenge. These conditions have traditionally been studied as isolated central nervous system disorders, but emerging evidence points to ...
Osayd Zohud, Iqbal M. Lone, Kareem Midlej, Fuad A. Iraqi   +3 more
wiley   +1 more source

Natural selection and genetic variation in a promising Chagas disease drug target: Trypanosoma cruzi trans-sialidase [PDF]

, 2017
Rational drug design is a powerful method in which new and innovative therapeutics can be designed based on knowledge of the biological target aiming to provide more efficacious and responsible therapeutics.
Gallant, Joseph P.
core   +1 more source

Prediction of drug–disease associations based on reinforcement symmetric metric learning and graph convolution network

Frontiers in Pharmacology
Accurately identifying novel indications for drugs is crucial in drug research and discovery. Traditional drug discovery is costly and time-consuming.
Huimin Luo, Huimin Luo, Chunli Zhu, Chunli Zhu, Jianlin Wang, Jianlin Wang, Ge Zhang, Ge Zhang, Junwei Luo, Chaokun Yan, Chaokun Yan, Chaokun Yan   +11 more
doaj   +1 more source

Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IXβ Reductase B as a Novel Thrombocytopenia Therapeutic Target

, 2021
Myeongkyu Kim, Jung-Hye Ha, Joonhyeok Choi, Boram Kim, Vytautas Gapsys, Ko On Lee, Jun‐Goo Jee, Kalyan S. Chakrabarti, Bert L. de Groot, Christian Griesinger, Kyoung‐Seok Ryu, Donghan Lee   +11 more
openalex   +2 more sources

O2 Activation at an Enzymatic Diiron Site: Bridging Ligand Substitutions Alter Diferric‐(Hydro)peroxo States

Angewandte Chemie International Edition, EarlyView.
Substituting the bridging carboxylates in diFe sulerythrin shifts the bridging ligand coordination from 1,3‐carboxylate to 1,1‐carboxylate, yielding all three diferrous bridging motifs in one protein. This shortens the Fe–Fe distance and increases reactivity with O2.
Jae‐Hun Jeoung, Stefan Rünger, Kilian Weißer, Jakob Ruickoldt, Samriddhi Bhattacharya, Christian Limberg, Holger Dobbek   +6 more
wiley   +1 more source

Accurate Drug Repositioning through Non-tissue-Specific Core Signatures from Cancer Transcriptomes

Cell Reports, 2018
Summary: Experimental large-scale screens for drug repositioning are limited by restriction to in vitro conditions and lack of applicability to real human conditions. Here, we developed an in silico screen in human in vivo conditions using a reference of
Chi Xu, Daosheng Ai, Shengbao Suo, Xingwei Chen, Yizhen Yan, Yaqiang Cao, Na Sun, Weizhong Chen, Joseph McDermott, Shiqiang Zhang, Yingying Zeng, Jing-Dong Jackie Han   +11 more
doaj   +1 more source

Machine Learning and drug repositioning

, 2021
Carlos Santolaria
openalex   +2 more sources

Japan and Japanese firms: historical and modern lessons for international business and economic development [PDF]

, 2020
The obsession in both the popular and academic press about Japan, Japanese firms and their management practices lasted until the 1990s, after which there has been an inexplicable absence of curiosity.
Narula, Rajneesh
core  

Drug Repositioning Applied to Cardiovascular Disease in Mucopolysaccharidosis [PDF]

, 2022
Gerda Cristal Villalba Silva, Thiago Steindorff, Roselena Silvestri Schuh, Natalia Cardoso Flores, Úrsula da Silveira Matte   +4 more
openalex   +1 more source

N‐of‐1 trials in clinical research: Methodological foundations, statistical approaches and implementation challenges

British Journal of Clinical Pharmacology, EarlyView.
N‐of‐1 trials offer a unique and rigorous methodology for evaluating individualized treatment responses, particularly within the context of personalized medicine. This article provides a comprehensive explanation of the conceptual and methodological underpinnings of N‐of‐1 trials, with particular emphasis on statistical techniques and considerations ...
Marcos Clint Leal De Carvalho, Matheus de Matos Dourado Simões, Ubiratan Cardinalli Adler, Antonio Brazil Viana Junior, Caren Nádia Soares de Sousa, Lia Lira Olivier Sanders   +5 more
wiley   +1 more source