Results 151 to 160 of about 1,821,409 (281)

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Spatial-spectral fusion enables drug repositioning by capturing indirect and long-range associations in biological networks. [PDF]

Bioinformatics
Zhu X, Wang L, Tang R, Huang ZA, Huang YA, Tan F, Hu L, You Z, Hu P.   +8 more
europepmc   +1 more source

Protective Effects of Imeglimin Against Oxaliplatin‐Induced Peripheral Neurotoxicity: Evidence From In Vitro and In Vivo Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT Oxaliplatin is a platinum‐based anticancer agent widely used for gastrointestinal malignancies; however, it is known to cause dose‐dependent peripheral neuropathy (OIPN), a characteristic adverse effect. OIPN results in a reduced quality of life and often necessitates dose reduction or discontinuation of oxaliplatin; however, effective ...
Yusuke Koura, Kano Kinjo, Keisuke Mine, Yusuke Mori, Mami Ueda, Risa Kaneko, Yuna Kamiya, Taiga Sonoda, Haruka Mimata, Shunsuke Fujita, Takehiro Kawashiri, Daisuke Kobayashi   +11 more
wiley   +1 more source

Integrated Approaches in Drug Repositioning Highlight Ouabain and Helenalin as Potential Drug Candidates for Pulmonary Fibrosis. [PDF]

Comput Struct Biotechnol J
Al-Abdulraheem Z, Juppi HK, Morikka J, Inkala S, Perho N, Sani S, Serra A, Federico A, Fratello M, Greco D.   +9 more
europepmc   +1 more source

Review on drug repositioning of some FDA-approved drugs for treatment of cancer/microbial diseases. [PDF]

RSC Adv
Ismail MMF, Shawer TZ, ElBakry OM, Baumy EAA, Eissa SI.   +4 more
europepmc   +1 more source

Patient Centring in CT: An International Survey of Clinical Practice and Future Directions

Journal of Medical Radiation Sciences, EarlyView.
An international survey of 321 radiographers from 43 countries found vertical mis‐centring below the CT isocentre is the most frequent positioning error. Only 34% had access to automated centring systems and 17% used them consistently. Substantial knowledge gaps exist regarding radiation dose and CT number variability, highlighting the need for ...
Yasser H. Hadi, Mo'men Bani‐Ahmad, Niamh Moore, Kevin R. Clark, Yazan Al‐Hayek, Salman M. Albeshan, Sultan B. Alghamdi, Helle Precht, Andrew England, Mark McEntee   +9 more
wiley   +1 more source

When Side Effects Become Therapies: A Mechanistic Taxonomy of Adverse Drug Reactions as Translational Signals for Drug Repositioning. [PDF]

Fundam Clin Pharmacol
Emanuele E, Minoretti P, Ballerio M, Santos-Lozano A, Lista S, Caraci F, Nisticò R.   +6 more
europepmc   +1 more source

Dasatinib and quercetin prevent alveolar bone loss in aged mice

Journal of Periodontology, EarlyView.
Abstract Background Recent findings have associated alveolar bone loss (ABL) with the presence of senescent cells. Aging and the accumulation of senescent cells are associated with a pro‐inflammatory environment which may exacerbate tissue damage.
Luisa S. Battistelli, Renata M. Moraes, Yuri C. Santos, Jaqueline L. Ribeiro, Maíra T. Garcia, Renata F. Prado, Florent Elefteriou, Ana Lia Anbinder   +7 more
wiley   +1 more source

Unlocking new therapeutic horizons through integrative bioinformatics and transcriptomics for drug repositioning in breast cancer therapy. [PDF]

J Egypt Natl Canc Inst
Adikusuma W, Irham LM, Satria RD, Nurlaila I, Dewi DL, Firdayani F, Syafarina I.   +6 more
europepmc   +1 more source

Smoking effects on root coverage outcomes between 3 and 12 months: A prospective cohort study

Journal of Periodontology, EarlyView.
Abstract Background This study aimed to evaluate the impact of smoking on root coverage outcomes, comparing healing responses at 3–12 months following coronally advanced flap with a connective tissue graft (CAF+CTG). Methods This prospective cohort study included 27 participants (13 smokers, 14 non‐smokers) who required root coverage for a single Cairo
Hande Has‐Elci, Duygu Taş, Zeliha Güney, Merve Atak, Sivge Kurgan, Muhittin A. Serdar, Dimitris N. Tatakis   +6 more
wiley   +1 more source