Results 181 to 190 of about 1,821,409 (281)

Improving enteral nutrition in patients requiring neurological intensive care unit care: A retrospective study on a novel bedside nasointestinal tube placement technique

Nutrition in Clinical Practice, EarlyView.
Abstract Background This study aimed to develop and assess a bedside nasojejunal tube placement technique designed for resource‐limited settings to address the specific challenges of enteral nutrition (EN) delivery in neurocritical care patients, particularly those at high risk of reflux and aspiration. The technique sought to overcome the drawbacks of
Niuchenglin, Liujuan, Zhushuibing, Dingyuanliang, Yutianhao, Shiguangling   +5 more
wiley   +1 more source

Integrating population-level and cell-based signatures for drug repositioning. [PDF]

Bioinformatics
He C, Xu Y, Zhou Y, Fan J, Cheng C, Meng R, Wu L, Pan R, Shah RV, Gamazon ER, Zhou D.   +10 more
europepmc   +1 more source

Computational Drug Repositioning

Computational drug repositioning -- the systematic identification of new therapeutic applications for approved orinvestigational drugs using computational analysis of molecular, genomic, clinical, and pharmacological data -- offers afundamentally faster and cheaper drug development pathway by leveraging the established safety and ...
Hugo Klein, Laura Klein, Helena Dubois
openaire   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Redefining Breast Cancer Care by Harnessing Computational Drug Repositioning. [PDF]

Medicina (Kaunas)
Jurj ED, Colibășanu D, Vasii SO, Suciu L, Dehelean CA, Udrescu L.   +5 more
europepmc   +1 more source

What Is the Role of Uvulopalatopharyngoplasty in Contemporary Sleep Surgery?

The Laryngoscope, EarlyView.
Thomas M. Kaffenberger, Megan Durr, Ryan Soose, Patrick J. Strollo, Jolie L. Chang   +4 more
wiley   +1 more source

Mesenchymal stem cells as cellular factories for targeted P2X7 blockade after traumatic brain injury

Neuroprotection, EarlyView.
This manuscript presents a novel therapeutic strategy using mesenchymal stem cells (MSCs) engineered as living drug factories to deliver a P2X7‐blocking nanobody for treatment of ischemic stroke. By combining targeted cellular delivery with sustained local immunomodulation, the approach aims to overcome key limitations of systemic biologic ...
Lucia Fadon‐Padilla, Chengyan Chu, Lorissa McDougall, Yajie Liang, Chinmoy Sarkar, Marta Lipinski, Tim Magnus, Miroslaw Janowski, Piotr Walczak   +8 more
wiley   +1 more source

Drug Repositioning for Multiresistant <i>Staphylococcus aureus</i> and <i>Escherichia coli</i> from Pandemic Response Box and Global Health Priority Box of MMV. [PDF]

ACS Omega
Gonçalves DS, Silva NBS, Santos ALO, de Souza SL, Calefi GG, Menezes RP, de Oliveira AM, Honório-Silva G, de Andrade CM, Almeida MPO, Fernandes TAM, Barbosa BF, Ferro EAV, Sabino-Silva R, Martins CHG.   +14 more
europepmc   +1 more source

Different Stakeholders, Different Pathways: How Capacity Profiles Shape Managerial Priorities for Beneficiaries and Staff in Decision‐Making

Nonprofit Management and Leadership, EarlyView.
ABSTRACT This study investigates how combinations of organizational capacities shape nongovernmental organization (NGO) managers' prioritization of staff and beneficiaries. While stakeholder theory identifies which stakeholders' interests attract attention, it offers limited guidance on how managers ultimately prioritize among stakeholders in decision ...
Robbie Waters Robichau, Tara Kolar Bryan, Rebekah St. Clair Sims   +2 more
wiley   +1 more source

Antagonizing NRG1-ERBB4 signaling pathway with spironolactone for the treatment of schizophrenia: results of a randomized controlled drug repositioning clinical trial. [PDF]

Commun Med (Lond)
Hasan A, Leucht S, Roeh A, Langguth B, Hansbauer M, Oviedo-Salcedo T, Greiner SK, Papazova I, Löhrs L, Maurus I, Strube W, Rossner MJ, Wehr MC, Bauer I, Heres S, Kreuzer PM, Zimmermann S, Schneider-Axmann T, Görlitz T, Baumgartner A, Karch S, Egert-Schwender S, Blankenstein C, Rothe P, Wagner E, Aminifarsani Z, Downie B, Leucht C, Falkai P.   +28 more
europepmc   +1 more source