Results 171 to 180 of about 25,894 (252)

Different Stakeholders, Different Pathways: How Capacity Profiles Shape Managerial Priorities for Beneficiaries and Staff in Decision‐Making

Nonprofit Management and Leadership, EarlyView.
ABSTRACT This study investigates how combinations of organizational capacities shape nongovernmental organization (NGO) managers' prioritization of staff and beneficiaries. While stakeholder theory identifies which stakeholders' interests attract attention, it offers limited guidance on how managers ultimately prioritize among stakeholders in decision ...
Robbie Waters Robichau, Tara Kolar Bryan, Rebekah St. Clair Sims   +2 more
wiley   +1 more source

Drug repositioning of regorafenib for renal cell carcinoma identifies <i>DDR2</i>‑associated sensitivity in ACHN models. [PDF]

Korean J Physiol Pharmacol
Moon J, Vo VTA, Nhat LT, Eom M, Jeong Y.
europepmc   +1 more source

Evaluating the efficacy of obturator cryoneurolysis for hip adductor spasticity: An observational, prospective study

PM&R, EarlyView.
Abstract Background Hip adductor spasticity is a common affliction among patients with disorders of the central nervous system. Cryoneurolysis is a novel intervention for spasticity involving the application of extreme cold to a nerve. This induces axonal breakdown, relieving spasticity.
Fraser MacRae, Mahdis Hashemi, Paul Winston   +2 more
wiley   +1 more source

Drug repositioning model based on knowledge graph embedding. [PDF]

Sci Rep
He S, Zhao X.
europepmc   +1 more source

Bt agave: why it is time to explore a new biotechnological frontier

Pest Management Science, EarlyView.
Drylands cover 41% of Earth, requiring sustainable crops. Agave, drought‐ and heat‐adapted, offers high‐value products with low water needs. Pests limit yield, yet Bacillus thuringiensis (Bt) Cry proteins, successful in other plants, remain unexploited in Agave.
Aline Vitória Corim Marim, Marcelo Falsarella Carazzolle, Gonçalo Amarante Guimarães Pereira, Carolina Rossi De Oliveira   +3 more
wiley   +1 more source

Disease–Drug–Drug Interaction of Imatinib in COVID‐19 ARDS: A Pooled Population Pharmacokinetic Analysis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 583-595, March 2025.
ABSTRACT Prior pharmacokinetic (PK) analysis revealed that increased alpha‐1‐acid glycoprotein (AAG) levels are associated with decreased imatinib unbound fraction in coronavirus disease 2019 (COVID‐19) patients. This study aimed to investigate the PK of total and unbound concentrations of imatinib and the metabolite N‐desmethyl imatinib in ...
Medhat M. Said, Job R. Schippers, Leila Atmowihardjo, Yingxue Li, Mick S. van der Plas, Harm J. Bogaard, Lieuwe D. J. Bos, Ron A. A. Mathôt, Jurjan Aman, Eleonora L. Swart, Imke H. Bartelink   +10 more
wiley   +1 more source

A Systems Biology and Drug Repositioning Approach for the Analysis of Mutual Genes Between Celiac Disease and Irritable Bowel Syndrome. [PDF]

Biomed Res Int
Al-Madhagi H.
europepmc   +1 more source

What Is the Role of Uvulopalatopharyngoplasty in Contemporary Sleep Surgery?

The Laryngoscope, EarlyView.
Thomas M. Kaffenberger, Megan Durr, Ryan Soose, Patrick J. Strollo, Jolie L. Chang   +4 more
wiley   +1 more source

Farnesoid X receptor prevents hyperuricemia via activating ATP‐binding cassette subfamily G member 2

Rheumatology &Autoimmunity, EarlyView.
Farnesoid X receptor (FXR) activation reduces serum uric acid levels by upregulating the intestinal urate transporter ATP‐binding cassette subfamily G member 2 (ABCG2). These findings uncover a novel metabolic pathway for urate excretion and suggest that FXR agonists (e.g., obeticholic acid), represent a promising therapeutic strategy for the treatment
Rui Li, Guo Tang, Ye Yu, Guang‐Liang Chen, Liangjing Lu, Juan Wang   +5 more
wiley   +1 more source

Exploring the shared gene signatures between rheumatoid arthritis and type 2 diabetes and their implication for drug repositioning on bioinformatics analysis. [PDF]

Medicine (Baltimore)
Qu X, Zuo X, Du H, Chen Y, Zhang Q, Peng H, Ma K, Zhang F, Cai Y, Tan L, Deng H, Chen X.   +11 more
europepmc   +1 more source