Results 201 to 210 of about 1,821,409 (281)

Farnesoid X receptor prevents hyperuricemia via activating ATP‐binding cassette subfamily G member 2

Rheumatology &Autoimmunity, EarlyView.
Farnesoid X receptor (FXR) activation reduces serum uric acid levels by upregulating the intestinal urate transporter ATP‐binding cassette subfamily G member 2 (ABCG2). These findings uncover a novel metabolic pathway for urate excretion and suggest that FXR agonists (e.g., obeticholic acid), represent a promising therapeutic strategy for the treatment
Rui Li, Guo Tang, Ye Yu, Guang‐Liang Chen, Liangjing Lu, Juan Wang   +5 more
wiley   +1 more source

Dual-route embedding-aware graph neural networks for drug repositioning. [PDF]

Brief Bioinform
Zhao Y, Chen Y, Du J, Wen J, Sun Q, Wang R, Chen C.   +6 more
europepmc   +1 more source

A Mixed‐Methods Study of a Short‐Term Professional Development as an Entry Point to School‐Based Participatory Science

Science Education, EarlyView.
ABSTRACT School‐based participatory science (SBPS) connects school science with authentic research practices; however, adoption in formal schooling depends on how teachers interpret SBPS and appraise its feasibility under institutional constraints.
Ho Yeong Yu, Ho Choi, Jae Geun Kim
wiley   +1 more source

SMPR: a structure-enhanced multimodal drug‒disease prediction model for drug repositioning and cold start. [PDF]

J Cheminform
Dong X, Miao R, Zhang S, Jia S, Zhang L, Liang Y, Zhang J, Zhu YZ.   +7 more
europepmc   +1 more source

Are client ties pre‐entry resources? Performance implications of client tie diversification

Strategic Management Journal, EarlyView.
Abstract Research Summary This study investigates client tie diversification, where firms enter markets with existing clients. Recognizing the theoretical basis for both positive and negative performance implications, the paper adopts a question‐driven approach and discovers a strong negative correlation between client tie diversification and firm ...
Heejung Byun
wiley   +1 more source

How Can Pharmacology Help Us Overcome the Challenges of Drug Repositioning as Antivirals to Treat Emerging Pathogens? The Example of Covid-19. [PDF]

Clin Transl Sci
Ben Ghezala I, Peiffer-Smadja N, Solas C, Nougairède A, Touret F, Bardou M.   +5 more
europepmc   +1 more source

Two‐Photon Endomicroscopy for Image‐Guided Magnetic Micro‐Agents

Small, EarlyView.
Image‐guided manipulation of magnetic micro‐agents requires localized fluorescence feedback capable of resolving dynamic interactions in confined environments. This study introduces a two‐photon endomicroscopy platform for real‐time motion tracking, multicolor micro‐agent discrimination, and imaging through biological tissue.
Juan J. Huaroto, Gert‐willem Römer, Ivo M. Vellekoop, Sarthak Misra   +3 more
wiley   +1 more source

MVSGDR: multi-view stacked graph convolutional network for drug repositioning. [PDF]

Brief Bioinform
Gu G, Wu H, Han H, Lin Z, Sun Y, Xie G, Su Q, Liu Z.   +7 more
europepmc   +1 more source

Driving Drugs Deeper: Force‐Driven Microneedle Systems for Active Therapy and Their Road Towards Clinical Implementation

Small, EarlyView.
Force‐driven microneedles are presented as active therapeutic microdevices that overcome the diffusion limits of conventional patches. By integrating gas generation, magnetic actuation, cavitation, or iontophoresis, these systems drive payloads deeper into tissue, enabling faster, more controlled delivery and highlighting key design principles and ...
Majed Amini, Phoebe Li, Hamed Shahsavan, Mahla Poudineh   +3 more
wiley   +1 more source

Drug Repositioning of Pegbing® for Essential Thrombocythemia: Insights from PK/PD Modeling and Extrapolation. [PDF]

Clin Pharmacol Ther
Jian W, Yin Y, Chen R, Xue J, Gu J, Du Z, He R, Zhou T.   +7 more
europepmc   +1 more source