Results 201 to 210 of about 25,687 (255)

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

Cancer Science, EarlyView.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo, Yuqian Feng, Jiamin Lu, Nuerbiye Abudurexiti, Xinlei Zhou, Mengfan Wei, Song Zheng   +6 more
wiley   +1 more source

Using systems biology and drug repositioning approaches to discover FDA-approved drugs candidates for endometriosis treatment. [PDF]

PLoS One
Sanami S, Aghaamoo S, Ahmad S, Fazli A, Mansouri B, Nobre Oliveira JI, Rahmanian M.   +6 more
europepmc   +1 more source

Negotiating Responsibility: Professionals' Perspectives on Separated Parents' Protective Duties in the Swedish Context

Child &Family Social Work, EarlyView.
ABSTRACT This study explores how social workers perceive and enact informal protective arrangements in the context of Swedish child protection. Drawing on group interviews with practitioners, the findings reveal that social workers underline parents' legal obligation and duty to protect their children, which means that the safe parent is expected to ...
Emma Rindeskog, Lupita Svensson
wiley   +1 more source

Recent advances in drug repositioning and rediscovery for different therapeutic activities utilizing updated technological approaches. [PDF]

Mol Divers
Nossier ES, Anwar MM, El-Zahabi MA.
europepmc   +1 more source

Powerful, Weightless, and Free: Reconceptualising Young People's Narratives of Resistance in the Context of Sexual Violence and Exploitation Using Recognition Theory

Children &Society, EarlyView.
ABSTRACT Meeting the needs of young people affected by sexual exploitation, alongside other forms of extra‐familial harm, remains a challenge for social workers, youth workers and other professionals responsible for their safety and well‐being. This paper proposes that to more effectively create safety with/for young people, we must re‐examine how we ...
Kristine Langhoff, Camille Warrington, Becky Warnock   +2 more
wiley   +1 more source

Identification of Potential Nontoxic Human <i>BTK</i> Inhibitors through an Integrated Deep Learning and Structure-Based Drug Repositioning Strategy. [PDF]

ACS Omega
Iqbal MW, Sun X, Yuan Q.
europepmc   +1 more source

Prevalence of Post‐Operative Complications in Autotransplanted Teeth: A Long‐Term Retrospective Cohort

Dental Traumatology, EarlyView.
ABSTRACT Background/Aims To evaluate the prevalence and timing of post‐operative complications following tooth autotransplantation, identify factors associated with earlier diagnosis, and report long‐term survival and success rates. Materials and Methods A single‐centre retrospective cohort study was conducted at a Czech university dental clinic (2003 ...
Juraj Marton, Radovan Žižka, Linda Kučerová, Přemysl Krejčí, Martin Starosta, Zdeněk Pokorný   +5 more
wiley   +1 more source

Drug repositioning pipeline integrating community analysis in drug-drug similarity networks and automated ATC community labeling to foster molecular docking analysis. [PDF]

Front Bioinform
Colibăşanu D, Groza V, Occhiuzzi MA, Grande F, Udrescu M, Udrescu L.   +5 more
europepmc   +1 more source

Balancer‐assisted sling recovery of critical equine patients after general anaesthesia

Equine Veterinary Education, EarlyView.
Summary Background Traditional sling‐based systems to assist horses during recovery from general anaesthesia (GA) could be improved by adding a balancer to obtain a dynamic weight relief. Objectives To evaluate the applicability of a novel balancer‐assisted sling system during recovery of horses after GA and to report initial experiences with high‐risk
J. Kuhlmann, C. Spadavecchia, C. Koch
wiley   +1 more source

In-silico drug repositioning studies of Candida albicans Nitrogen permease reactivator 1 (Npr1) kinase. [PDF]

Sci Rep
Das S, Bagchi A, Bera A, Biswas A, Roy A, Ganguly R, Mondal A, Chattopadhyay D, Mondal PS, Mondal T, Samanta S, Goswami AM, Saha T.   +12 more
europepmc   +1 more source