Results 201 to 210 of about 60,427 (345)

Aging-related Repositioned Drugs, Donepezil and Sildenafil Citrate, Increase Apoptosis of Anti-mitotic Drug-resistant KBV20C Cells Through Different Molecular Mechanisms [PDF]

, 2018
Ji Yeong Kim, Ji Yeon Son, Byung‐Mu Lee, Hyung Sik Kim, Sungpil Yoon   +4 more
openalex   +1 more source

Drug Repositioning in Doxorubicin-Induced Cardiotoxicity Protection. [PDF]

Int J Mol Sci
Kosić M, Pajović V, Jovanović M, Japundžić-Žigon N.   +3 more
europepmc   +1 more source

Systems pharmacology and drug repositioning- an integrated approach to metabolic diseases [PDF]

, 2012
Michael Luther
openalex   +1 more source

Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano, Giulia Apprato, Serena Francisco, Giuseppe Ermondi, Giulia Caron   +4 more
wiley   +1 more source

Sexual dimorphism of COVID-19 inspires drug repositioning and host-targeting immunotherapy for viral pneumonia. [PDF]

Signal Transduct Target Ther
Yuan L, Xiao H, Liu X, Zhou M, Zhang C, Wu K, Ye J, Zhang L, Li X, Ma J, Fang M, Zhang Y, Yuan Q, Chen R, Zhu H, Guan Y, Cheng T, Xia N.   +17 more
europepmc   +1 more source

Drug Repositioning for Alzheimer’s Disease: A Delphi Consensus and Stakeholder Consultation

Janet Sultana, Clive Ballard, Kate Stych, Kathryn Mills, Anne Corbett   +4 more
openalex   +1 more source

Repeatability of Metabolic Imaging With Hyperpolarized Pyruvate: Back‐to‐Back Neuroimaging and Blood Analysis

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose 13C MRI with hyperpolarized [1‐13C]pyruvate enables noninvasive imaging of metabolic pathways. Considering the high dose of pyruvate used in hyperpolarized 13C‐pyruvate studies, circulating 13C‐pyruvate and the resulting 13C‐lactate in plasma may influence subsequent pyruvate metabolism, yet the guidance on consecutive injections does ...
Jun Chen, Sung‐Han Lin, Jessica Sudderth, Kelley A. Derner, Crystal E. Harrison, Maheen Zaidi, Jeannie D. Baxter, Jeff Liticker, Zohreh Erfani, Craig R. Malloy, Marco C. Pinho, Ralph J. DeBerardinis, Jae Mo Park   +12 more
wiley   +1 more source

Computational drug repositioning approach to predict multi-target therapeutics for epilepsy. [PDF]

Sci Rep
Kumar P, Kumar V, Chauhan R, Saini V, Kumar A.   +4 more
europepmc   +1 more source

Computational drug repositioning through heterogeneous network clustering [PDF]

, 2013

core   +1 more source

Improving enteral nutrition in patients requiring neurological intensive care unit care: A retrospective study on a novel bedside nasointestinal tube placement technique

Nutrition in Clinical Practice, EarlyView.
Abstract Background This study aimed to develop and assess a bedside nasojejunal tube placement technique designed for resource‐limited settings to address the specific challenges of enteral nutrition (EN) delivery in neurocritical care patients, particularly those at high risk of reflux and aspiration. The technique sought to overcome the drawbacks of
Niuchenglin, Liujuan, Zhushuibing, Dingyuanliang, Yutianhao, Shiguangling   +5 more
wiley   +1 more source