Results 211 to 220 of about 25,894 (252)

Improving drug repositioning accuracy using non-negative matrix tri-factorization. [PDF]

Sci Rep
Li Q, Wang Y, Wang J, Zhao C.
europepmc   +1 more source

Repositioning Drugs for Psychiatry.

Avicenna journal of medical biotechnology
openaire   +1 more source

Drug repositioning: a brief overview [PDF]

Journal of Pharmacy and Pharmacology, 2020
Abstract Objectives Drug repositioning, that is, the use of a drug in an indication other than the one for which it was initially marketed, is a growing trend. Its origins lie mainly in the attrition experienced in recent years in the field of new drug discovery.
Christophe Rochais, Jean-Pierre Jourdan, Patrick Dallemagne   +2 more
exaly   +5 more sources

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Drug Repositioning in Oncology

American Journal of Therapeutics, 2021
Background: The worldwide increase in the occurrence of cancer associated with the limitations of immunotherapy and the emergence of resistance have impaired the prognosis of cancer patients, which leads to the search for alternative treatment methods.
Marissa B, Serafin, Angelita, Bottega, Taciéli F, da Rosa, Catrine S, Machado, Vitória S, Foletto, Silvana S, Coelho, Augusto D, da Mota, Rosmari, Hörner   +7 more
openaire   +2 more sources

Drug repositioning for orphan diseases [PDF]

Briefings in Bioinformatics, 2011
The need and opportunity to discover therapeutics for rare or orphan diseases are enormous. Due to limited prevalence and/or commercial potential, of the approximately 6000 orphan diseases (defined by the FDA Orphan Drug Act as
Anil Jegga, Minlu Zhang, Yang Lun
exaly   +3 more sources

Drug Repositioning on the Cloud

2011 IEEE Third International Conference on Cloud Computing Technology and Science, 2011
Market pressures have driven pharmaceutical companies to reassess their current drug development model and reach out to new innovative business models such as drug repositioning. Various techniques that are used in drug repositioning lend themselves to the distributed computing model. The \cloud is one such computing model that optimizes resource usage
Vassilis Virvilis, Anuj Sharma, Miltiadis Koutsokeras   +2 more
openaire   +1 more source

Drug repositioning for Alzheimer's disease

Nature Reviews Drug Discovery, 2012
Existing drugs for Alzheimer's disease provide symptomatic benefit for up to 12 months, but there are no approved disease-modifying therapies. Given the recent failures of various novel disease-modifying therapies in clinical trials, a complementary strategy based on repositioning drugs that are approved for other indications could be attractive ...
Amritpal Mudher, James Pickett, Paul Edison   +2 more
exaly   +5 more sources

Off-Patent Drug Repositioning

Journal of Chemical Information and Modeling, 2020
Drug repositioning aims to reuse "old" drugs to treat diseases outside their approved indication(s). Composition-of-matter patents and FDA exclusivities can hinder the immediate availability of some drugs to be repositioned (repurposed). Here, we analyze data from the FDA Orange Book and use current on-market patent validity and exclusivities to ...
Sorin I. Avram, Ramona Curpan, Liliana Halip, Alina Bora, Tudor I. Oprea   +4 more
openaire   +3 more sources

Network-based drug repositioning

Molecular BioSystems, 2013
Abstract Network-based computational biology, with the emphasis on biomolecular interactions and omics-data integration, has had success in drug development and created new directions such as drug repositioning and drug combination. Drug repositioning, i.e., revealing a drug's new roles, is increasingly attracting much attention from ...
Zikai, Wu, Yong, Wang, Luonan, Chen
openaire   +2 more sources

In Silico Drug Repositioning for Chagas Disease

Current Medicinal Chemistry, 2020
: Chagas disease is an infectious tropical disease included within the group of neglected tropical diseases. Though historically endemic to Latin America, it has lately spread to high-income countries due to human migration. At present, there are only two available drugs, nifurtimox and benznidazole, approved for this treatment, both with considerable
Bellera, Carolina Leticia, Alberca, Lucas Nicolás, Sbaraglini, Maria Laura, Talevi, Alan   +3 more
openaire   +3 more sources