Results 221 to 230 of about 60,427 (345)

Fetal Instability and Resuscitative Management During Fetal Intervention: A Retrospective, Descriptive Analysis of 245 Fetal Cardiac and Spina Bifida Procedures

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective The heterogeneity of fetal surgery has led to variability in the nature and frequency of fetal instability. Understanding these differences is critical for optimizing management. Methods We reviewed all fetal atrial septal interventions (FASI) and fetoscopic myelomeningocele (fMMC) repairs with fetal instability performed at our ...
Claire A. Naus, Betul Yilmaz Furtun, Jessian L. Munoz, Rebecca M. Johnson, Carolyn A. Altman, Michael A. Belfort, Luc Joyeux, Alice King, David G. Mann, Shaine Morris, Athar M. Qureshi, Magdalena Sanz Cortes, William E. Whitehead, Caitlin D. Sutton   +13 more
wiley   +1 more source

Integrated analysis for drug repositioning in migraine using genetic evidence and claims database. [PDF]

Front Big Data
Inokuchi S, Tajima T.
europepmc   +1 more source

Disease–Drug–Drug Interaction of Imatinib in COVID‐19 ARDS: A Pooled Population Pharmacokinetic Analysis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 583-595, March 2025.
ABSTRACT Prior pharmacokinetic (PK) analysis revealed that increased alpha‐1‐acid glycoprotein (AAG) levels are associated with decreased imatinib unbound fraction in coronavirus disease 2019 (COVID‐19) patients. This study aimed to investigate the PK of total and unbound concentrations of imatinib and the metabolite N‐desmethyl imatinib in ...
Medhat M. Said, Job R. Schippers, Leila Atmowihardjo, Yingxue Li, Mick S. van der Plas, Harm J. Bogaard, Lieuwe D. J. Bos, Ron A. A. Mathôt, Jurjan Aman, Eleonora L. Swart, Imke H. Bartelink   +10 more
wiley   +1 more source

Targeting Cancer Cell Energy Metabolism in Colorectal Cancer: Opportunities and Challenges from Drug Repositioning. [PDF]

Cells
Tomassini L, Pacifico T, Monteleone G, Stolfi C, Laudisi F.   +4 more
europepmc   +1 more source

Repositioning Proton Pump Inhibitors as Anticancer Drugs by Targeting the Thioesterase Domain of Human Fatty Acid Synthase

, 2014
Valerie Fako, Xi Wu, Beth R. Pflug, Jing-Yuan Liu, Jian‐Ting Zhang   +4 more
openalex   +2 more sources

Diurnal‐Only Foslevodopa/Foscarbidopa

Movement Disorders Clinical Practice, EarlyView.
Alexandra McGuckin, Yu‐Yan Poon, Galit Kleiner, Alfonso Fasano   +3 more
wiley   +1 more source

Farnesoid X receptor prevents hyperuricemia via activating ATP‐binding cassette subfamily G member 2

Rheumatology &Autoimmunity, EarlyView.
Farnesoid X receptor (FXR) activation reduces serum uric acid levels by upregulating the intestinal urate transporter ATP‐binding cassette subfamily G member 2 (ABCG2). These findings uncover a novel metabolic pathway for urate excretion and suggest that FXR agonists (e.g., obeticholic acid), represent a promising therapeutic strategy for the treatment
Rui Li, Guo Tang, Ye Yu, Guang‐Liang Chen, Liangjing Lu, Juan Wang   +5 more
wiley   +1 more source

Dual-route embedding-aware graph neural networks for drug repositioning. [PDF]

Brief Bioinform
Zhao Y, Chen Y, Du J, Wen J, Sun Q, Wang R, Chen C.   +6 more
europepmc   +1 more source

Non-Negative Matrix Factorization for Drug Repositioning: Experiments with the repoDB Dataset.

, 2019
Gokhan Bakal, Halil Kilicoglu, Ramakanth Kavuluru   +2 more
openalex   +1 more source

A two-step drug repositioning method based on a protein-protein interaction network of genes shared by two diseases and the similarity of drugs [PDF]

, 2013
Yutaka Fukuoka, Daiki Takei, Hisamichi Ogawa   +2 more
openalex   +1 more source