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BJU International, Volume 135, Issue 4, Page 700-705, April 2025.
Yubo Wang +10 more
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Repositioning Drugs for Psychiatry.
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Drug repositioning: a brief overview [PDF]
International audienceAbstract Objectives Drug repositioning, that is, the use of a drug in an indication other than the one for which it was initially marketed, is a growing trend.
Christophe Rochais +2 more
exaly +6 more sources
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Drug Repositioning in Oncology
American Journal of Therapeutics, 2021Background: The worldwide increase in the occurrence of cancer associated with the limitations of immunotherapy and the emergence of resistance have impaired the prognosis of cancer patients, which leads to the search for alternative treatment methods.
Marissa B, Serafin +7 more
openaire +2 more sources
Drug repositioning for orphan diseases [PDF]
The need and opportunity to discover therapeutics for rare or orphan diseases are enormous. Due to limited prevalence and/or commercial potential, of the approximately 6000 orphan diseases (defined by the FDA Orphan Drug Act as
Anil Jegga, Minlu Zhang
exaly +4 more sources
MeSHDD: Literature-based drug-drug similarity for drug repositioning
Objective: Drug repositioning is a promising methodology for reducing the cost and duration of the drug discovery pipeline. We sought to develop a computational repositioning method leveraging annotations in the literature, such as Medical Subject ...
Adam Brown, Chirag Patel
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Drug Repositioning on the Cloud
2011 IEEE Third International Conference on Cloud Computing Technology and Science, 2011Market pressures have driven pharmaceutical companies to reassess their current drug development model and reach out to new innovative business models such as drug repositioning. Various techniques that are used in drug repositioning lend themselves to the distributed computing model. The \cloud is one such computing model that optimizes resource usage
Vassilis Virvilis +2 more
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Journal of Chemical Information and Modeling, 2020
Drug repositioning aims to reuse "old" drugs to treat diseases outside their approved indication(s). Composition-of-matter patents and FDA exclusivities can hinder the immediate availability of some drugs to be repositioned (repurposed). Here, we analyze data from the FDA Orange Book and use current on-market patent validity and exclusivities to ...
Sorin I. Avram +4 more
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Drug repositioning aims to reuse "old" drugs to treat diseases outside their approved indication(s). Composition-of-matter patents and FDA exclusivities can hinder the immediate availability of some drugs to be repositioned (repurposed). Here, we analyze data from the FDA Orange Book and use current on-market patent validity and exclusivities to ...
Sorin I. Avram +4 more
openaire +4 more sources
Changing Trends in Computational Drug Repositioning [PDF]
Maximizing the indications potential and revenue from drugs that are already marketed offers a new take on the famous mantra of the Nobel Prize-winning pharmacologist, Sir James Black, “The most fruitful basis for the discovery of a new drug is to start with an old drug”.
Jaswanth Yella +2 more
exaly +4 more sources
Network-based drug repositioning
Molecular BioSystems, 2013Abstract Network-based computational biology, with the emphasis on biomolecular interactions and omics-data integration, has had success in drug development and created new directions such as drug repositioning and drug combination. Drug repositioning, i.e., revealing a drug's new roles, is increasingly attracting much attention from ...
Zikai, Wu, Yong, Wang, Luonan, Chen
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