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Drug repositioning for Alzheimer's disease
Nature Reviews Drug Discovery, 2012Existing drugs for Alzheimer's disease provide symptomatic benefit for up to 12 months, but there are no approved disease-modifying therapies. Given the recent failures of various novel disease-modifying therapies in clinical trials, a complementary strategy based on repositioning drugs that are approved for other indications could be attractive ...
Corbett, Anne +17 more
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Challenges and opportunities of drug repositioning
Trends in Pharmacological Sciences, 2013Drug repositioning is an innovation stream of pharmaceutical development that offers advantages for drug developers along with safer medicines for patients. Several drugs have been successfully repositioned to a new indication, with the most prominent of them being viagra and thalidomide, which have generated historically high revenues.
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In Silico Drug Repositioning for Chagas Disease
Current Medicinal Chemistry, 2020: Chagas disease is an infectious tropical disease included within the group of neglected tropical diseases. Though historically endemic to Latin America, it has lately spread to high-income countries due to human migration. At present, there are only two available drugs, nifurtimox and benznidazole, approved for this treatment, both with considerable
Bellera, Carolina Leticia +3 more
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Network‐Based Approaches for Drug Repositioning
Molecular Informatics, 2021AbstractWith deep learning creeping up into the ranks of big data, new models based on deep learning and massive data have made great leaps forward rapidly in the field of drug repositioning. However, there is no relevant review to summarize the transformations and development process of models and their data in the field of drug repositioning.
Tao Song +5 more
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Repositioning Drugs: A Computational Approach
Current Drug Research ReviewsComputational drug repositioning has emerged as an efficient approach to discovering new indications for existing drugs, offering lower risk and cost compared to traditional drug discovery methods. Various computational approaches have been developed, including targetbased, gene-expression-based, phenome-based,
Bhawna Sharma +5 more
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2017
This chapter focuses on the basic elements of computational drug repositioning and overviews the various in silico, in vivo, and in vitro approaches. It describes the use of Systematic Drug Repositioning (SDR) technologies to predict hitherto unknown adverse drug reactions (ADRs), or to derive mechanistic explanations of known ADRs.
Spyros N. Deftereos +5 more
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This chapter focuses on the basic elements of computational drug repositioning and overviews the various in silico, in vivo, and in vitro approaches. It describes the use of Systematic Drug Repositioning (SDR) technologies to predict hitherto unknown adverse drug reactions (ADRs), or to derive mechanistic explanations of known ADRs.
Spyros N. Deftereos +5 more
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La Revue du praticien
DRUG REPOSITIONING. Developing new therapeutic agents ("de novo") for human diseases is an increasingly lengthy and costly process, aimed at ensuring patient safety and drug efficacy. An alternative approach, drug repurposing or repositioning, involves using already commercialized or advanced molecules.
Clémence, Réda +2 more
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DRUG REPOSITIONING. Developing new therapeutic agents ("de novo") for human diseases is an increasingly lengthy and costly process, aimed at ensuring patient safety and drug efficacy. An alternative approach, drug repurposing or repositioning, involves using already commercialized or advanced molecules.
Clémence, Réda +2 more
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A Review of Computational Drug Repositioning Approaches
Combinatorial Chemistry & High Throughput Screening, 2018Computational drug repositioning emerges as a new idea of drug discovery and development. Contrary to conventional routines, computational drug repositioning encompasses low risk and high safety. Some successful cases demonstrated its advantage. Therefore, a large number of computational drug repositioning approaches have been developed over the past ...
Guohua, Huang +3 more
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Drug Repositioning: An Approach for Drug Discovery
Mini-Reviews in Organic Chemistry, 2016Parin Vora, Rakesh Somani, Madhuri Jain
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