Results 271 to 280 of about 60,427 (345)

Repositioning antimalarial drugs as anticancer agents: focus on Tafenoquine

Christopher E. Barton, Bailey Blair, Libby Godo, Anna Gray, Lydia Heron-Goar, Holly A. Hill, Amanda Long, H. S. Moore, Rylee Rickett, Sandra Tomas   +9 more
openalex   +1 more source

Patient-derived organoid xenografts model esophageal cancer cachexia and enable assessment of anti-inflammatory drug repositioning. [PDF]

iScience
Lung BC, Leung AK, Wong CW, Wong IY, Lung CCH, Lo AW, Ko JM, Dai W, Kwong DL, Law S, Lung ML, Yu VZ.   +11 more
europepmc   +1 more source

Repositioning the Repurposed Drug, a Structural Study of Thalidomide Analogs

, 2019
Mahshid Rahmat, Romanos Sklavenitis Pistofidis, Irene M. Ghobrial   +2 more
openalex   +1 more source

Schedule‐dependent neuroprotection by pioglitazone in a novel model of α‐synucleinopathy in rats: Integrated behavioural and histological outcomes

British Journal of Pharmacology, EarlyView.
Background and Purpose α‐Synucleinopathies are neurodegenerative disorders characterized by the aggregation and propagation of misfolded α‐synuclein. In Parkinson's disease (PD), the most common α‐synucleinopathy, the progression of motor and nonmotor deficits, and dopaminergic neuron loss, are closely linked to the spreading of misfolded α‐synuclein ...
Alberto Santiago‐Balmaseda, Marcos M. Villegas‐Rojas, Isaac Pérez‐Segura, Maricela Espino‐Cambrón, Daniel Martinez‐Fong, Luis O. Soto‐Rojas   +5 more
wiley   +1 more source

JI‐CJ002 and Dabrafenib Combination Enhances Antitumor Activity in Melanoma Associated With the Downregulation of B7‐H3

Cancer Science, EarlyView.
Schematic pathway diagram illustrating the effects of JI‐CJ002 and dabrafenib on melanoma progression. The combination of JI‐CJ002 and dabrafenib is associated with reduced B7‐H3 expression and modulation of signaling pathways implicated in melanoma progression, including JAK2/STAT3, PI3K/AKT/mTOR, and Rb/E2F1.
Sang‐Eun Lee, Young Ha Kim, Bo Shin Heo, Chunhoo Cheon, Seong‐Gyu Ko   +4 more
wiley   +1 more source

Computational Drug Repositioning in Cardiorenal Disease: Opportunities, Challenges, and Approaches. [PDF]

Proteomics
Perco P, Ley M, Kęska-Izworska K, Wojenska D, Bono E, Walter SM, Fillinger L, Kratochwill K.   +7 more
europepmc   +1 more source

Recovery beyond the individual: Toward a place‐based paradigm for recovery science

Addiction, EarlyView.
Victoria Frances Burns
wiley   +1 more source

Negotiating Responsibility: Professionals' Perspectives on Separated Parents' Protective Duties in the Swedish Context

Child &Family Social Work, EarlyView.
ABSTRACT This study explores how social workers perceive and enact informal protective arrangements in the context of Swedish child protection. Drawing on group interviews with practitioners, the findings reveal that social workers underline parents' legal obligation and duty to protect their children, which means that the safe parent is expected to ...
Emma Rindeskog, Lupita Svensson
wiley   +1 more source

RNA sequencing identifies lung cancer lineage and facilitates drug repositioning

Longjin Zeng, Longyao Zhang, Lingchen Li, Xingyun Liao, Chenrui Yin, Lincheng Zhang, Xiewan Chen, Jianguo Sun   +7 more
openalex   +1 more source

Advancing addiction science through the study of recovery trajectories

Addiction, EarlyView.
Jo‐Hanna H. Ivers
wiley   +1 more source