Results 141 to 150 of about 26,660 (305)

Mining integrated semantic networks for drug repositioning opportunities

, 2016
Joseph Mullen, Simon Cockell, Hannah Tipney, Peter Woollard, Anil Wipat   +4 more
openalex   +1 more source

Napabucasin transforms liver microenvironment and boosts immunotherapy efficacy by converting potential metastases into “hot” tumors

Interdisciplinary Medicine, EarlyView.
Napabucasin reduces liver metastases by reprogramming the hepatic microenvironment. It induces hepatocyte secretion of CCL21 via c‐Fos activation, recruiting lymphocytes and converting “cold” metastases into immunologically “hot” tumors. This effect is liver‐specific and independent of cancer cells.
Qiongqiong Wang, Jiaqi Zhou, Hang Qiao, Yifan Jia, Ling Ye, Zeli Li, Jiahe Ouyang, Haoxian Zhou, Kangxin Zeng, Xuemeng Wang, Yixian Wang, Yang Zhang, Yupeng Zhang, Yizhou Cai, Yutao Hu, Minzhe Zhang, Wenwei Xu, Zhenzhen Wu, Xiaofang Qiu, Li Lin   +19 more
wiley   +1 more source

Repositioning FDA-Approved Sulfonamide-Based Drugs as Potential Carbonic Anhydrase Inhibitors in Trypanosoma cruzi: Virtual Screening and In Vitro Studies [PDF]

Eyra Ortíz-Pérez, Adriana Moreno‐Rodríguez, Timoteo Delgado‐Maldonado, Jessica L. Ortega-Balleza, Alonzo González‐González, Alma D. Paz-González, Karina Vázquez, Guadalupe Ávalos-Navarro, Simone Giovannuzzi, Claudiu T. Supuran, Gildardo Rivera   +10 more
openalex   +1 more source

Diagnosis of Amniotic Sac Herniation Into Uterine Dehiscence Using Combined Ultrasound and Magnetic Resonance Imaging—A Rare Complication Following Fetoscopic Laser Photocoagulation

Journal of Clinical Ultrasound, EarlyView.
Fistula of the anterior uterine wall, through which the amniotic sac of the recipient communicated with the anechoic area outside the uterus (left: ultrasound imaging; right: MRI imaging; star: amniotic sac herniation; arrow: fistula; triangle: bladder).
Ziling Liu, Hongqin Chen, Jie Ruan
wiley   +1 more source

The Relational Dimension in Gestalt Psychotherapy: Epistemological and Clinical Aspects

The Journal of Humanistic Counseling, EarlyView.
ABSTRACT This article reframes Gestalt psychotherapy as intrinsically relational: experience and self‐emerge from contact at the organism–environment boundary and from the field/situation. We revisit ambiguities in the Perls/Goodman model against a brief historical background and articulate a pragmatic stance grounded in the id of the situation and ...
Pietro Andrea Cavaleri, Serena Iacono Isidoro   +1 more
wiley   +1 more source

Are the detection and dimensions of peri‐implant buccal bone defects influenced by different implant materials and their location? An experimental cone‐beam computed tomography study

Journal of Periodontology, EarlyView.
Abstract Background The aim of this study is to evaluate the impact of different implant materials and arrangements within the field of view (FOV) and exomass on the diagnostic accuracy and image quality of cone‐beam computed tomography (CBCT) for the detection of peri‐implant buccal bone defects of various sizes. Methods A total of 120 CBCT scans with
Yulan Wang, Matheus L. Oliveira, Dorothea Dagassan‐Berndt, Michelle Simonek, Sebastian Kühl, Michael M. Bornstein   +5 more
wiley   +1 more source

Repositioning salicylanilide anthelmintic drugs to treat adenovirus infections

, 2019
José Antonio Marrugal‐Lorenzo, Ana Serna‐Gallego, Judith Berastegui‐Cabrera, Jerónimo Pachón, Javier Sánchez‐Céspedes   +4 more
openalex   +1 more source

Supplementary Figure S5 from A Drug Repositioning Approach Identifies Tricyclic Antidepressants as Inhibitors of Small Cell Lung Cancer and Other Neuroendocrine Tumors

, 2023
Nadine S. Jahchan, Joel T. Dudley, Paweł K. Mazur, Natasha Flores, Dian Yang, Alec Palmerton, Anne‐Flore Zmoos, Dedeepya Vaka, Kim Q.T. Tran, Margaret Zhou, Karolina Krasinska, Jonathan W. Riess, Joel W. Neal, Purvesh Khatri, Nicole Kirk, Atul J. Butte, Julien Sage   +16 more
openalex   +1 more source

In Silico Repositioning-Chemogenomics Strategy Identifies New Drugs with Potential Activity against Multiple Life Stages of Schistosoma mansoni

, 2015
Bruno J. Neves, Rodolpho C. Braga, José Clecildo Barreto Bezerra, Pedro Cravo, Carolina Horta Andrade   +4 more
openalex   +2 more sources

Improving enteral nutrition in patients requiring neurological intensive care unit care: A retrospective study on a novel bedside nasointestinal tube placement technique

Nutrition in Clinical Practice, EarlyView.
Abstract Background This study aimed to develop and assess a bedside nasojejunal tube placement technique designed for resource‐limited settings to address the specific challenges of enteral nutrition (EN) delivery in neurocritical care patients, particularly those at high risk of reflux and aspiration. The technique sought to overcome the drawbacks of
Niuchenglin, Liujuan, Zhushuibing, Dingyuanliang, Yutianhao, Shiguangling   +5 more
wiley   +1 more source