Results 301 to 310 of about 60,427 (345)

Improving drug repositioning with negative data labeling using large language models. [PDF]

open access: yesJ Cheminform
Picard M   +5 more
europepmc   +1 more source

Drug repositioning for Alzheimer's disease

Nature Reviews Drug Discovery, 2012
Existing drugs for Alzheimer's disease provide symptomatic benefit for up to 12 months, but there are no approved disease-modifying therapies. Given the recent failures of various novel disease-modifying therapies in clinical trials, a complementary strategy based on repositioning drugs that are approved for other indications could be attractive ...
Corbett, Anne   +17 more
openaire   +6 more sources

Drug Repositioning in Oncology

American Journal of Therapeutics, 2021
Background: The worldwide increase in the occurrence of cancer associated with the limitations of immunotherapy and the emergence of resistance have impaired the prognosis of cancer patients, which leads to the search for alternative treatment methods.
Marissa B, Serafin   +7 more
openaire   +2 more sources

Off-Patent Drug Repositioning

Journal of Chemical Information and Modeling, 2020
Drug repositioning aims to reuse "old" drugs to treat diseases outside their approved indication(s). Composition-of-matter patents and FDA exclusivities can hinder the immediate availability of some drugs to be repositioned (repurposed). Here, we analyze data from the FDA Orange Book and use current on-market patent validity and exclusivities to ...
Sorin Avram   +4 more
openaire   +3 more sources

Network-based drug repositioning

Molecular BioSystems, 2013
Network-based computational biology, with the emphasis on biomolecular interactions and omics-data integration, has had success in drug development and created new directions such as drug repositioning and drug combination. Drug repositioning, i.e., revealing a drug's new roles, is increasingly attracting much attention from the pharmaceutical ...
Zikai, Wu, Yong, Wang, Luonan, Chen
openaire   +2 more sources

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