Results 221 to 230 of about 82,231 (299)

Computational Drug Repurposing for Alzheimer's Disease via Sheaf Theoretic Population-Scale Analysis of snRNA-Seq Data. [PDF]

J Med Chem
Cottrell S, Yoon S, Wei X, Dickson A, Wei GW.   +4 more
europepmc   +1 more source

Rhenium Complexes as Antimicrobial Agents

Helvetica Chimica Acta, EarlyView.
Rhenium complexes are stepping into the fight against superbugs. Our new review explores how these metallic complexes could inspire the next generation of antimicrobial therapies. ABSTRACT The escalating crisis of antimicrobial resistance (AMR) necessitates the exploration of unconventional therapeutic scaffolds.
Fabio Zobi, Gozde Demirci, Marija Rasic
wiley   +1 more source

Pattern Recognition Algorithms in Pharmacogenomics and Drug Repurposing-Case Study: Ribavirin and Lopinavir. [PDF]

Pharmaceuticals (Basel)
Calvo H, Islas-Díaz D, Hernández-Laureano E.   +2 more
europepmc   +1 more source

Pyridoxal Reprograms Peroxisomal Hydrogen Peroxide Metabolism to Induce Lethal Oxidative Stress in Ovarian Cancer

iMetaMed, EarlyView.
Pyridoxal (PL) exhibits the strongest anti‐tumor activity within the vitamin B6 family, demonstrating significant ovarian cancer cell‐killing efficacy in vivo, in vitro, and in patient‐derived organoid (PDO) models. The anti‐tumor mechanism involves PL inducing a shift in peroxisome dynamics towards fission, promoting peroxisome proliferation, and ...
Ruonan Li, Huiyan Wang, Dunke Zhang, Qiuying Gu, Jinlong Wang, Bin Liu, Huabin Gao, Jingya Duan, Yimin Liu, Xiaolan Huang, Youquan Bu, Tongchuan He, Hua Linghu   +12 more
wiley   +1 more source

GARD: Genomic Data-Based Drug Repurposing in Head and Neck Cancer with Large Language Model Validation. [PDF]

Cancers (Basel)
Tanikella P, Nenad W, Courtine C, Dai Y, Deng Q, Zou B, Osazuwa-Peters N, Schrank TP, Wu D.   +8 more
europepmc   +1 more source

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, EarlyView.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

A network-driven computational framework for identifying FDA-approved drug repurposing across heterogeneous brain cancers. [PDF]

Front Mol Biosci
Prakash O.
europepmc   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

ConvAHKG: Action-based hybrid knowledge graph with a dual-channel convolutional approach for drug repurposing. [PDF]

Sci Rep
Khodadadi AghGhaleh M, Abedian R, Zarghami R, Fotuhi Siahpirani A, Gharaghani S.   +4 more
europepmc   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source