Results 151 to 160 of about 377,494 (308)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A meeting of the Joint FAO/WHO Expert Committee on Food Additives was held at WHO Headquarters, Geneva, from 15 to 24 February 2000 [PDF]

, 2001
Univ Complutense Madrid, Fac Vet Med, Dept Toxicol & Pharmacol, Madrid, SpainSwedish Univ Agr Sci, Fac Vet Med, Dept Pharmacol & Toxicol, S-75007 Uppsala, SwedenFed Inst Hlth Protect Consumers & Vet Med, Berlin, GermanyFrench Food Safety Agcy, Natl Agcy ...
Soback, S. S., Martinez, JLR, Appelgren, L. E., Anadon, A., McLean, J. G., Miller, M. A., Boisseau, J., Stephany, R. W., Palermo-Neto, João [UNIFESP], Boobis, A. R., MacNeil, J. D., Kinabo, LDB, Arnold, D., WHO   +13 more
core  

Simultaneous determination of 31 Sulfonamide residues in various livestock matrices using liquid chromatography-tandem mass spectrometry

Applied Biological Chemistry
The widespread use of sulfonamides can result in the residue of sulfonamides in the foods of animal origin that are the major concerns of consumers and regulatory bodies due to their adverse reaction such as the development of antibiotic resistance.
Yu Ra Kim, Sunyoung Park, Ji Young Kim, Jang-Duck Choi, Gui-Im Moon   +4 more
doaj   +1 more source

Prediction of Safety Risk Levels of Veterinary Drug Residues in Freshwater Products in China Based on Transformer. [PDF]

Foods, 2022
Jiang T, Liu T, Dong W, Liu Y, Hao C, Zhang Q.   +5 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Quantitative analysis method for isoeugenol in fishery products using gas chromatography–tandem mass spectrometry

Applied Biological Chemistry
Isoeugenol, an anesthetic used in marine products, has different regulations in each country and there is controversy regarding the degree of risk. Therefore, it is necessary to establish reliable analytical methods for detection and quantification.
Ye-Bin Jang, Yeong-Ju Jo, Mi-ok Kim, Gui-Hyun Jang   +3 more
doaj   +1 more source

Poly-Phthalocyanine-Doped Graphene Oxide Nanosheet Conjugates for Electrocatalytic Oxidation of Drug Residues. [PDF]

Front Chem, 2021
Chundu P, Dube E, Zinyama NP, Moyo M, Shumba M.   +4 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Antibacterial Drug Residues in Small Ruminant Edible Tissues and Milk: A Literature Review of Commonly Used Medications in Small Ruminants. [PDF]

Animals (Basel), 2022
Richards ED, Martin KL, Donnell CE, Clapham MO, Tell LA.   +4 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source