Results 61 to 70 of about 1,013,456 (328)

Role of xenobiotic transporters in bacterial drug resistance and virulence [PDF]

IUBMB Life, 2008
AbstractSince the discovery of antibiotic therapeutics, the battles between humans and infectious diseases have never been stopped. Humans always face the appearance of a new bacterial drug‐resistant strain followed by new antibiotic development. However, as the genome sequences of infectious bacteria have been gradually determined, a completely new ...
Akihito Yamaguchi, Kunihiko Nishino, Kunihiko Nishino   +2 more
openaire   +3 more sources

Multistrain models predict sequential multidrug treatment strategies to result in less antimicrobial resistance than combination treatment [PDF]

, 2016
Background Combination treatment is increasingly used to fight infections caused by bacteria resistant to two or more antimicrobials. While multiple studies have evaluated treatment strategies to minimize the emergence of resistant strains for single ...
Ahmad, Amais, Christiansen, Lasse Engbo, Græsbøll, Kaare, Matthews, Louise, Nielsen, Søren Saxmose, Olsen, John Elmerdahl, Toft, Nils, Zachariasen, Camilla   +7 more
core   +4 more sources

Rapid decline of bacterial drug-resistance in an antibiotic-free environment through phenotypic reversion

eLife, 2019
Antibiotic resistance typically induces a fitness cost that shapes the fate of antibiotic-resistant bacterial populations. However, the cost of resistance can be mitigated by compensatory mutations elsewhere in the genome, and therefore the loss of ...
Anett Dunai, Réka Spohn, Z. Farkas, Viktória Lázár, Adam Gyorkei, G. Apjok, G. Boross, Balázs Szappanos, Gábor Grézal, Anikó Faragó, L. Bodai, Balázs Papp, Csaba Pál   +12 more
semanticscholar   +1 more source

Can we prevent antimicrobial resistance by using antimicrobials better? [PDF]

, 2013
Since their development over 60 years ago, antimicrobials have become an integral part of healthcare practice worldwide. Recently, this has been put in jeopardy by the emergence of widespread antimicrobial resistance, which is one of the major problems ...
Brown, Caron, Cars, Cars, Collignon, Dagan, DiNubile, Drlica, Essack, Fox, Geli, Goren, Gould, Guillemot, Harris, Hurdle, Huttner, Isha, Madurell, Masterton, Michalsen, Mitchison, Mitchison, Molstad, Sharma, Solapure, Talbot, Thomas   +27 more
core   +2 more sources

Applying definitions for multidrug resistance, extensive drug resistance and pandrug resistance to clinically significant livestock and companion animal bacterial pathogens.

Journal of Antimicrobial Chemotherapy, 2018
Standardized definitions for MDR are currently not available in veterinary medicine despite numerous reports indicating that antimicrobial resistance may be increasing among clinically significant bacteria in livestock and companion animals.
M. T. Sweeney, B. Lubbers, S. Schwarz, J. Watts   +3 more
semanticscholar   +1 more source

Antimicrobial treatment improves mycobacterial survival in nonpermissive growth conditions [PDF]

, 2014
Antimicrobials targeting cell wall biosynthesis are generally considered inactive against nonreplicating bacteria. Paradoxically, we found that under nonpermissive growth conditions, exposure of Mycobacterium bovis BCG bacilli to such antimicrobials ...
Andrew, Peter W, Burke, Bernard, Butcher, Philip D, Cohen-Gonsaud, Martin, Glenn, Sarah, Labesse, Gilles, Mukamolova, Galina V, Sarybaeva, Asel A, Tudo, Griselda, Turapov, Obolbek, Waddell, Simon J, Young, Danielle I, Young, Michael   +12 more
core   +2 more sources

Study of antimicrobial resistance profile and efflux mediated drug resistance in clinical isolates of Pseudomonas aeruginosa detected by ethidium bromide-agar Cartwheel method [PDF]

, 2022
Background: Development of antibiotic resistance or multidrug resistance (MDR) is one of the major causes of treatment failure of bacterial infections and has rapidly evolved into a threat to global health care.
K. N., Silpa, Krishnan, Shinu, Kumar K. S., Harish, Murali, Radhika, Raj, Ananthu, S., Anagha, Theckel, Philip George   +6 more
core   +2 more sources

Nutrient Gradients Mediate Complex Colony-Level Antibiotic Responses in Structured Microbial Populations

Frontiers in Microbiology, 2022
Antibiotic treatments often fail to eliminate bacterial populations due to heterogeneity in how individual cells respond to the drug. In structured bacterial populations such as biofilms, bacterial metabolism and environmental transport processes lead to
Mirjana Stevanovic, Thomas Boukéké-Lesplulier, Thomas Boukéké-Lesplulier, Lukas Hupe, Lukas Hupe, Jeff Hasty, Jeff Hasty, Jeff Hasty, Philip Bittihn, Philip Bittihn, Philip Bittihn, Daniel Schultz   +11 more
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

The Promising Viral Threat to Bacterial Resistance: The Uncertain Patentability of Phage Therapeutics and the Necessity of Alternative Incentives [PDF]

, 2014
Bacteriophages, or “phages,” are a category of highly adept and adaptable viruses that can infect and kill bacteria. With concerns over the burgeoning antibiotic-resistance crisis looming in recent years, scientists and policymakers have expressed a ...
Todd, Kelly
core   +2 more sources