Results 61 to 70 of about 780,065 (189)
Antimicrobial peptides for combating drug-resistant bacterial infections
Drug Resistance Updates, 2023 The problem of drug resistance due to long-term use of antibiotics has been a concern for years. As this problem grows worse, infections caused by multiple bacteria are expanding rapidly and are extremely detrimental to human health. Antimicrobial peptides (AMPs) are a good alternative to current antimicrobials with potent antimicrobial activity and ...
Jiaqi Xuan +8 more
openaire +2 more sources
Interplay in the selection of fluoroquinolone resistance and bacterial fitness. [PDF]
PLoS Pathogens, 2009 Fluoroquinolones are antibacterial drugs that inhibit DNA Gyrase and Topoisomerase IV. These essential enzymes facilitate chromosome replication and RNA transcription by regulating chromosome supercoiling.
Linda L Marcusson +2 more
doaj +1 more source
The Mechanism of Bacterial Resistance and Potential Bacteriostatic Strategies
Antibiotics, 2022 Bacterial drug resistance is rapidly developing as one of the greatest threats to human health. Bacteria will adopt corresponding strategies to crack the inhibitory effect of antibiotics according to the antibacterial mechanism of antibiotics, involving ...
Fusheng Zhang, Wei Cheng
semanticscholar +1 more source
Multidrug resistance: Versatile drug sensors of bacterial cells [PDF]
Current Biology, 1999 One way that bacteria resist antimicrobial agents involves 'drug sensors', proteins that bind a range of structurally unrelated antimicrobial drugs and induce expression of multidrug resistance pumps. The basis for drug recognition is now becoming clear from the recently determined crystal structure of a drug sensor.
openaire +3 more sources
Multi-Drug Resistance in Bacterial Genomes—A Comprehensive Bioinformatic Analysis
International Journal of Molecular Sciences, 2023 Antimicrobial resistance is presently one of the greatest threats to public health. The excessive and indiscriminate use of antibiotics imposes a continuous selective pressure that triggers the emergence of multi-drug resistance. We performed a large-scale analysis of closed bacterial genomes to identify multi-drug resistance considering the ResFinder ...
Domingues, Célia P. F. +3 more
openaire +3 more sources
eLife, 2020 Metabolism of host-targeted drugs by the microbiome can substantially impact host treatment success. However, since many host-targeted drugs inadvertently hamper microbiome growth, repeated drug administration can lead to microbiome evolutionary ...
Brittany Rosener +6 more
doaj +1 more source
Emergence of Herbal Antimicrobial Drug Resistance in Clinical Bacterial Isolates
, 2015 Alternative medicines have been practiced for centuries and remained as integral part of many civilizations around the globe. One important aspect of alternative medicine includes herbal medicines/drugs in which locally available plants or its parts are ...
P. Vadhana +3 more
semanticscholar +1 more source
Molecular Ecology, 2015 Drug resistance is a costly consequence of pathogen evolution and a major concern in public health. In this review, we show how population genetics can be used to study the evolution of drug resistance and also how drug resistance evolution is ...
Benjamin A. Wilson +4 more
semanticscholar +1 more source
Emerging Infectious Diseases, 2003 We conducted a retrospective study of the clinical aspects of bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA) with heterogeneously reduced susceptibility to vancomycin.
Mitchell J. Schwaber +8 more
doaj +1 more source
PLoS Biology, 2017 Antibiotic regimens often include the sequential changing of drugs to limit the development and evolution of resistance of bacterial pathogens. It remains unclear how history of adaptation to one antibiotic can influence the resistance profiles when ...
Phillip Yen, Jason A Papin
doaj +1 more source