Results 41 to 50 of about 4,798,630 (303)

Drug resistance with monitored adherence [PDF]

, 2013
Drug resistance can be defined as the failure of a drug to exert its expected effect on pharmacological biomarkers and is caused by pharmacogenetic, cellular or clinical factors.
Walter, Philipp Niklaus
core   +1 more source

Major bacterial isolate and antibiotic resistance from routine clinical samples in Southern Ethiopia

Scientific Reports, 2021
Currently, antibiotic-resistant bacterial infections are a challenge for the health care system. Although physicians demand timely drug resistance data to guide empirical treatment, local data is rather scarce. Hence, this study performed a retrospective
Mengistu Hailemariam, Tsegaye Alemayehu, Bereket Tadesse, Netsanete Nigussie, Asnakech Agegnehu, Techilo Habtemariam, Mulubrhan Ali, Enkosilassie Mitiku, Elshaday Azerefegne   +8 more
doaj   +1 more source

Development and application of the active surveillance of pathogens microarray to monitor bacterial gene flux. [PDF]

, 2008
BACKGROUND: Human and animal health is constantly under threat by emerging pathogens that have recently acquired genetic determinants that enhance their survival, transmissibility and virulence.
Oyston, Petra C. F., Titball, Richard W., Hinds, Jason, Richard W Titball, Wren, Brendan W, Dawson, LF, Titball Richard W, Dawson Lisa F, Lisa F Dawson, Richard A Stabler, Wren, Brendan W., Oyston, Petra CF, Titball, RW, Stabler, Richard A, Dawson, Lisa F, Dawson, Lisa F., Hinds Jason, Oyston, PCF, Stabler, Richard A., Stabler Richard A, Wren, BW, Witney, AA, Petra CF Oyston, Titball, Richard W, Oyston Petra CF, Witney, Adam A, Jim Wade, Witney Adam A, Witney, Adam A., Hinds, J, Wren Brendan W, Wade, Jim, Jason Hinds, Wade, J, Stabler, RA, Oyston, PC, Adam A Witney, Wade Jim, Brendan W Wren   +38 more
core   +1 more source

Fifty years of chicken-source Salmonella in China: Evolutionary shifts in epidemiology, antimicrobial resistance, and genomic lineages

Poultry Science
Salmonella, as a profound foodborne zoonotic pathogen, not only causes acute and chronic disorders in poultry but can also be transmitted to humans through the food chain, posing a serious threat to public health security.
Fangqin Liu, Lu Zhang, Qingchun Shen, Shouzhen Xu, Hejia Wang, Chunping Zhang   +5 more
doaj   +1 more source

In Silico Screen Identifies a New Family of Agonists for the Bacterial Mechanosensitive Channel MscL

Antibiotics, 2022
MscL is a highly conserved mechanosensitive channel found in the majority of bacterial species, including pathogens. It functions as a biological emergency release valve, jettisoning solutes from the cytoplasm upon acute hypoosmotic stress.
Robin Wray, Paul Blount, Junmei Wang, Irene Iscla   +3 more
doaj   +1 more source

Antimicrobial Resistance in Commensal Flora of Pig Farmers

Emerging Infectious Diseases, 2004
We assessed the quantitative contribution of pig farming to antimicrobial resistance in the commensal flora of pig farmers by comparing 113 healthy pig farmers from the major French porcine production areas to 113 nonfarmers, each matched for sex, age ...
Hélène Aubry-Damon, Karine Grenet, Penda Sall-Ndiaye, Didier Che, Eugenio Cordeiro, Marie-Elisabeth Bougnoux, Emma Rigaud, Yann Le Strat, Véronique Lemanissier, Laurence Armand-Lefèvre, Didier Delzescaux, Jean-Claude Desenclos, Michel Liénard, Antoine Andremont   +13 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Hsp90 governs dispersion and drug resistance of fungal biofilms [PDF]

, 2011
Fungal biofilms are a major cause of human mortality and are recalcitrant to most treatments due to intrinsic drug resistance. These complex communities of multiple cell types form on indwelling medical devices and their eradication often requires ...
Ramage Gordon, Lopez-Ribot, J.L., Rajendran Ranjith, Ramage, G., Leah E. Cowen, Uppuluri Priya, Robbins, N., Priya Uppuluri, Rajendran, R., Andes, D., Jose L Lopez-Ribot, David Andes, Leah E Cowen, Nicole Robbins, Uppuluri, P., Robbins Nicole, Nett Jeniel, Lopez-Ribot Jose L., Jose L. Lopez-Ribot, Cowen, L.E., Nett, J., Ranjith Rajendran, Gordon Ramage, Jeniel Nett, Andes David, Cowen Leah E.   +25 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Spread of anti-malarial drug resistance: mathematical model with implications for ACT drug policies. [PDF]

, 2008
BACKGROUND: Most malaria-endemic countries are implementing a change in anti-malarial drug policy to artemisinin-based combination therapy (ACT). The impact of different drug choices and implementation strategies is uncertain.
Hastings, Ian M, Day, Nicholas PJ, White, Nicholas J., Dondorp, AM, Hastings, Ian M., Dondorp, Arjen M, Dondorp, Adrianus, Hastings, Ian, Day, Nicholas P. J., Pongtavornpinyo, W, Hastings, IM, Pongtavornpinyo, Wirichada, White, Nicholas J, Day, Nicholas, Day, Nicholas P.J., Yeung, Shunmay, Day, NP, White, NJ, White, Nicholas, Dondorp, Arjen M., Yeung, S, Hastings Ian M, Dondorp Arjen M, Pongtavornpinyo Wirichada, Day Nicholas PJ, Yeung Shunmay, White Nicholas J   +26 more
core   +1 more source