Results 31 to 40 of about 343,417 (268)

The Tol-Pal System of Uropathogenic Escherichia coli Is Responsible for Optimal Internalization Into and Aggregation Within Bladder Epithelial Cells, Colonization of the Urinary Tract of Mice, and Bacterial Motility

Frontiers in Microbiology, 2019
Urinary tracts infection (UTI) caused by uropathogenic Escherichia coli (UPEC) is a common infectious disease. With the shortage of new antimicrobial agents, the increase in UPEC resistance to commonly used drugs, such as fluoroquinolones and β-lactams ...
Hidetada Hirakawa, Kazutomo Suzue, Kumiko Kurabayashi, Haruyoshi Tomita, Haruyoshi Tomita   +4 more
doaj   +1 more source

Genomic dissection of nosocomial multiclonal-outbreak by carbapenem-resistant Pseudomonas aeruginosa strains in a tertiary children’s hospital in Japan

Journal of Global Antimicrobial Resistance
Objective: Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is an important antimicrobial-resistant bacterial pathogen. We observed an increase in the detection rate of CRPA isolates at a tertiary children’s hospital in Japan.
Akihiko Shimizu, Jun Kurushima, Koichi Tanimoto, Naoko Tomie, Yusuke Hashimoto, Takahiro Nomura, Natsuko Ota, Hidetada Hirakawa, Haruyoshi Tomita   +8 more
doaj   +1 more source

Eradication Therapy - Recent Trend in Research [PDF]

The Korean Journal of Helicobacter and Upper Gastrointestinal Research, 2020
It is well known that Helicobacter pylori (H. pylori) can cause peptic ulcer, mucosa-associated lymphoid tissue lymphoma, atrophic gastritis, intestinal metaplasia, and ultimately, gastric cancer. Various studies have proven that H.
Heung Up Kim
doaj   +1 more source

Fifty years of chicken-source Salmonella in China: Evolutionary shifts in epidemiology, antimicrobial resistance, and genomic lineages

Poultry Science
Salmonella, as a profound foodborne zoonotic pathogen, not only causes acute and chronic disorders in poultry but can also be transmitted to humans through the food chain, posing a serious threat to public health security.
Fangqin Liu, Lu Zhang, Qingchun Shen, Shouzhen Xu, Hejia Wang, Chunping Zhang   +5 more
doaj   +1 more source

Antimicrobial Resistance in Commensal Flora of Pig Farmers

Emerging Infectious Diseases, 2004
We assessed the quantitative contribution of pig farming to antimicrobial resistance in the commensal flora of pig farmers by comparing 113 healthy pig farmers from the major French porcine production areas to 113 nonfarmers, each matched for sex, age ...
Hélène Aubry-Damon, Karine Grenet, Penda Sall-Ndiaye, Didier Che, Eugenio Cordeiro, Marie-Elisabeth Bougnoux, Emma Rigaud, Yann Le Strat, Véronique Lemanissier, Laurence Armand-Lefèvre, Didier Delzescaux, Jean-Claude Desenclos, Michel Liénard, Antoine Andremont   +13 more
doaj   +1 more source

Major bacterial isolate and antibiotic resistance from routine clinical samples in Southern Ethiopia

Scientific Reports, 2021
Currently, antibiotic-resistant bacterial infections are a challenge for the health care system. Although physicians demand timely drug resistance data to guide empirical treatment, local data is rather scarce. Hence, this study performed a retrospective
Mengistu Hailemariam, Tsegaye Alemayehu, Bereket Tadesse, Netsanete Nigussie, Asnakech Agegnehu, Techilo Habtemariam, Mulubrhan Ali, Enkosilassie Mitiku, Elshaday Azerefegne   +8 more
doaj   +1 more source

In Silico Screen Identifies a New Family of Agonists for the Bacterial Mechanosensitive Channel MscL

Antibiotics, 2022
MscL is a highly conserved mechanosensitive channel found in the majority of bacterial species, including pathogens. It functions as a biological emergency release valve, jettisoning solutes from the cytoplasm upon acute hypoosmotic stress.
Robin Wray, Paul Blount, Junmei Wang, Irene Iscla   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source