Results 61 to 70 of about 4,798,630 (303)

Curcumin Quantum Dots Mediated Degradation of Bacterial Biofilms

Frontiers in Microbiology, 2017
Bacterial biofilm has been reported to be associated with more than 80% of bacterial infections. Curcumin, a hydrophobic polyphenol compound, has anti-quorum sensing activity apart from having antimicrobial action. However, its use is limited by its poor
Ashish K. Singh, Ashish K. Singh, Pradyot Prakash, Ranjana Singh, Nabarun Nandy, Zeba Firdaus, Monika Bansal, Ranjan K. Singh, Anchal Srivastava, Anchal Srivastava, Jagat K. Roy, Brahmeshwar Mishra, Rakesh K. Singh   +12 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Explaining risk factors for drug-resistant tuberculosis in England and Wales: contribution of primary and secondary drug resistance [PDF]

, 2004
Drug-resistant tuberculosis can be transmitted (primary) or develop during the course of treatment (secondary). We investigated risk factors for each type of resistance.
Glynn, JR, Story, A, Hayward, AC, Watson, JM, Conaty, SJ, Drobniewski, FA   +5 more
core   +1 more source

Nutrient Gradients Mediate Complex Colony-Level Antibiotic Responses in Structured Microbial Populations

Frontiers in Microbiology, 2022
Antibiotic treatments often fail to eliminate bacterial populations due to heterogeneity in how individual cells respond to the drug. In structured bacterial populations such as biofilms, bacterial metabolism and environmental transport processes lead to
Mirjana Stevanovic, Thomas Boukéké-Lesplulier, Thomas Boukéké-Lesplulier, Lukas Hupe, Lukas Hupe, Jeff Hasty, Jeff Hasty, Jeff Hasty, Philip Bittihn, Philip Bittihn, Philip Bittihn, Daniel Schultz   +11 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Interplay in the selection of fluoroquinolone resistance and bacterial fitness. [PDF]

PLoS Pathogens, 2009
Fluoroquinolones are antibacterial drugs that inhibit DNA Gyrase and Topoisomerase IV. These essential enzymes facilitate chromosome replication and RNA transcription by regulating chromosome supercoiling.
Linda L Marcusson, Niels Frimodt-Møller, Diarmaid Hughes   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Identification of markers associated with bacterial blight resistance loci in cowpea (Vigna unguiculata (L.) Walp.) [PDF]

, 2010
Cowpea bacterial blight (CoBB), caused by Xanthomonas axonopodis pv. vignicola (Xav), is a worldwide major disease of cowpea [Vigna unguiculata (L.) Walp.].
Roberts, P.A., K. Wydra, Fatokun, C. A., J. D. Ehlers, R. G. F. Visser, C. G. van der Linden, P. A. Roberts, Ehlers, J.D., Agbicodo, A.C.M.E., Visser, R.G.F., R. Bandyopadhyay, Diop, N.N., Close, T. J., Wydra, K., Muchero, W., van der Linden, C.G., N. N. Diop, T. J. Close, W. Muchero, Visser, R. G. F., C. A. Fatokun, Linden, C. G., Agbicodo, E. M., Ehlers, J. D., Close, T.J., Roberts, P. A., Diop, N. N., E. M. Agbicodo, Bandyopadhyay, R., Linden, C.G., van der, Fatokun, C.A.   +30 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Evolution of antibiotic resistance at non-lethal drug concentrations

, 2012
Human use of antimicrobials in the clinic, community and agricultural systems has driven selection for resistance in bacteria. Resistance can be selected at antibiotic concentrations that are either lethal or non-lethal, and here we argue that selection ...
Andersson, Dan I,, Hughes, Diarmaid,
core   +1 more source