Results 61 to 70 of about 336,058 (268)

Interventions on Metabolism: Making Antibiotic-Susceptible Bacteria

open access: yesmBio, 2017
Antibiotics act on bacterial metabolism, and antibiotic resistance involves changes in this metabolism. Interventions on metabolism with drugs might therefore modify drug susceptibility and drug resistance.
Fernando Baquero, José-Luis Martínez
doaj   +1 more source

Multidrug resistance: Versatile drug sensors of bacterial cells [PDF]

open access: yesCurrent Biology, 1999
One way that bacteria resist antimicrobial agents involves 'drug sensors', proteins that bind a range of structurally unrelated antimicrobial drugs and induce expression of multidrug resistance pumps. The basis for drug recognition is now becoming clear from the recently determined crystal structure of a drug sensor.
openaire   +2 more sources

Dual‐Layer Living Hydrogel Enables On‐Demand Delivery of Phages and Probiotics for Synergistic Wound Infection Therapy

open access: yesAdvanced Functional Materials, EarlyView.
A dual‐layer living hydrogel, ProΦGel, integrates bacteriophages and probiotics for synergistic wound infection therapy. The outer gelatin‐based matrix releases phages on demand in response to P. aeruginosa infections, while inner alginate beads sustain probiotic delivery.
Siyuan Tao   +6 more
wiley   +1 more source

The Association between Mycobacterium Tuberculosis Genotype and Drug Resistance in Peru.

open access: yesPLoS ONE, 2015
BackgroundThe comparison of Mycobacterium tuberculosis bacterial genotypes with phenotypic, demographic, geospatial and clinical data improves our understanding of how strain lineage influences the development of drug-resistance and the spread of ...
Louis Grandjean   +17 more
doaj   +1 more source

Multi-drug resistant gram-negative bacterial pneumonia: etiology, risk factors, and drug resistance patterns

open access: yesPneumonia, 2022
AbstractBacterial pneumonia is one of the most serious public health issues owing to its medical and economic costs, which result in increased morbidity and mortality in people of all ages around the world. Furthermore, antimicrobial resistance has risen over time, and the advent of multi-drug resistance in GNB complicates therapy and has a detrimental
openaire   +3 more sources

Drug‐Free Thrombolysis Mediated by Physically Activated Micro/Nanoparticles

open access: yesAdvanced Functional Materials, EarlyView.
Overview of particle‐mediated thrombolytic effects (thermal, mechanical, and chemical) and their activating physical stimuli (light, ultrasound, and magnetic field) in drug‐free thrombolysis. ABSTRACT Thrombus‐associated disorders rank among the world's leading causes of death, with ischemic heart disease and stroke as the main contributors.
Pierre Sarfati   +2 more
wiley   +1 more source

Biointerface Membranes Orchestrating Site‐Specific Osteoimmunomodulatory and Antibacterial Effects for Enhanced Osseous Regeneration in Periodontal Therapy

open access: yesAdvanced Functional Materials, EarlyView.
Here, a biointerface membrane engineered with site‐specific interfacial properties is developed. During implantation between gingival and bone defect, the membrane creates a pro‐osteogenic microenvironment, precisely modulates cellular activities at each biointerface, and facilitates the orchestration of complex healing events, ultimately leading to ...
Yuwei Zhu   +13 more
wiley   +1 more source

Investigating colistin drug resistance: The role of high-throughput sequencing and bioinformatics [version 2; peer review: 2 approved]

open access: yesF1000Research, 2019
Bacterial infections involving antibiotic-resistant gram-negative bacteria continue to increase and represent a major global public health concern.
Dickson Aruhomukama   +2 more
doaj   +1 more source

Novel Functional Materials via 3D Printing by Vat Photopolymerization

open access: yesAdvanced Functional Materials, EarlyView.
This Perspective systematically analyzes strategies for incorporating functionalities into 3D‐printed materials via Vat Photopolymerization (VP). It explores the spectrum of achievable functionalities in recently reported novel materials—such as conductive, energy‐storing, biodegradable, stimuli‐responsive, self‐healing, shape‐memory, biomaterials, and
Sergey S. Nechausov   +3 more
wiley   +1 more source

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