The crosstalk between efflux pump and resistance gene mutation in Helicobacter pylori
Gut MicrobesEfflux pumps play a crucial role in the development of antibiotic resistance. The aim of this study was to investigate the relationship between efflux pump gene expression and resistance gene mutations in Helicobacter pylori.
Xiaoling Gong +5 more
exaly +3 more sources
A novel role for colistin as an efflux pump inhibitor in multidrug-resistant Klebsiella pneumoniae [PDF]
Scientific ReportsAntimicrobial resistance (AMR) is a global challenge that demands new strategies to maintain the effectiveness of current treatments. AMR arises through various mechanisms, including overexpression of drug efflux pumps. The AcrAB-TolC efflux pump is used
Rajnikant Sharma +7 more
doaj +2 more sources
Bacterial Efflux Pump Inhibitors Reduce Antibiotic Resistance
PharmaceuticsBacterial resistance is a growing problem worldwide, and the number of deaths due to drug resistance is increasing every year. We must pay great attention to bacterial resistance.
Kun Mi, Lingli Huang, Fengying Gong
exaly +3 more sources
Evolutionary loss of an antibiotic efflux pump increases Pseudomonas aeruginosa quorum sensing mediated virulence in vivo [PDF]
Nature CommunicationsAntibiotic resistance is a threat to human health, yet recent work highlights how loss of resistance may drive pathogenesis in some bacteria. In two recent studies, we found that β-lactam antibiotics and nutrient stresses faced during infection selected ...
Sheryl E. Fernandes +12 more
doaj +2 more sources
Evaluating the ciprofloxacin potentiation efficacy of repurposed drug flupentixol through efflux pump inhibition of pathogenic bacteria [PDF]
Scientific ReportsAntimicrobial resistance concerning burdens is increasing day by day. Efflux pump upregulation is one of the mechanisms through which bacteria develop resistance to antibiotics.
Md. Momin-Reza +7 more
doaj +2 more sources
Journal of Pure and Applied Microbiology, 2022 AcrAB-TolC is a resistance nodulation division type of efflux pump present in Enterobacteriaceae. It non-specifically effluxes antibiotics out of the bacterial cell, thus conferring drug resistance.
Priyadharshini Sekar +3 more
doaj +1 more source
Antibiotics, 2021 Acinetobacter species are among the most life-threatening Gram-negative bacilli, causing hospital-acquired infections, and they are associated with high morbidity and mortality. They show multidrug resistance that acts via various mechanisms.
Nagaraju Bankan +4 more
doaj +1 more source
The RND Efflux Pump Gene Expression in the Biofilm Formation of Acinetobacter baumannii
Antibiotics, 2023 Multidrug resistant (MDR) Acinetobacter baumannii is a critical opportunistic pathogen in healthcare-associated infections (HAI). This is attributed to several factors, including its ability to develop biofilms that can enhance antimicrobial resistance ...
Ola A. Abd El-Rahman +4 more
doaj +1 more source
The contribution of antibiotic resistance mechanisms in clinical Burkholderia cepacia complex isolates: an emphasis on efflux pump activity. [PDF]
PLoS ONE, 2014 Due to the limited information of the contribution of various antibiotic resistance mechanisms in clinical Burkholderia cepacia complex isolates, Antibiotic resistance mechanisms, including integron analysis, identification of quinolone resistance ...
Sung-Pin Tseng +7 more
doaj +1 more source
Interplay between three RND efflux pumps in doxycycline-selected strains of Burkholderia thailandensis. [PDF]
PLoS ONE, 2013 BACKGROUND: Efflux systems are involved in multidrug resistance in most Gram-negative non-fermentative bacteria. We have chosen Burkholderia thailandensis to dissect the development of multidrug resistance phenotypes under antibiotic pressure ...
Fabrice Vincent Biot +9 more
doaj +1 more source