Results 1 to 10 of about 119,130 (155)
A Pseudomonas putida efflux pump acts on short-chain alcohols [PDF]
Biotechnology for Biofuels, 2018 Background The microbial production of biofuels is complicated by a tradeoff between yield and toxicity of many fuels. Efflux pumps enable bacteria to tolerate toxic substances by their removal from the cells while bypassing the periplasm.
Georg Basler +3 more
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Microbiology Spectrum, 2023 NorA, an extensively studied efflux pump in Staphylococcus aureus, has been connected to fluoroquinolone, antiseptic, and disinfection resistance. Several studies have also emphasized how efflux pumps, including NorA, function as the first line of ...
Nishtha Chandal +6 more
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The crosstalk between efflux pump and resistance gene mutation in Helicobacter pylori
Gut MicrobesEfflux pumps play a crucial role in the development of antibiotic resistance. The aim of this study was to investigate the relationship between efflux pump gene expression and resistance gene mutations in Helicobacter pylori.
Xiaoling Gong +5 more
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A novel role for colistin as an efflux pump inhibitor in multidrug-resistant Klebsiella pneumoniae [PDF]
Scientific ReportsAntimicrobial resistance (AMR) is a global challenge that demands new strategies to maintain the effectiveness of current treatments. AMR arises through various mechanisms, including overexpression of drug efflux pumps. The AcrAB-TolC efflux pump is used
Rajnikant Sharma +7 more
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Bacterial Efflux Pump Inhibitors Reduce Antibiotic Resistance
PharmaceuticsBacterial resistance is a growing problem worldwide, and the number of deaths due to drug resistance is increasing every year. We must pay great attention to bacterial resistance.
Lan Zhang +6 more
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Evolutionary loss of an antibiotic efflux pump increases Pseudomonas aeruginosa quorum sensing mediated virulence in vivo [PDF]
Nature CommunicationsAntibiotic resistance is a threat to human health, yet recent work highlights how loss of resistance may drive pathogenesis in some bacteria. In two recent studies, we found that β-lactam antibiotics and nutrient stresses faced during infection selected ...
Sheryl E. Fernandes +12 more
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Evaluating the ciprofloxacin potentiation efficacy of repurposed drug flupentixol through efflux pump inhibition of pathogenic bacteria [PDF]
Scientific ReportsAntimicrobial resistance concerning burdens is increasing day by day. Efflux pump upregulation is one of the mechanisms through which bacteria develop resistance to antibiotics.
Md. Momin-Reza +7 more
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Antibiotics, 2019 Multidrug efflux systems play a prominent role in medicine, as they are important contributors to bacterial antibiotic resistance. NorA is an efflux pump transporter from the major facilitator superfamily that expels numerous drug compounds across the ...
Sandra G. Zárate +4 more
doaj +3 more sources
Overexpression of the major facilitator superfamily efflux pump gene nfa56470 mediates ciprofloxacin resistance in Nocardia farcinica [PDF]
Frontiers in Cellular and Infection MicrobiologyObjectivesTo explore the molecular basis of ciprofloxacin resistance in N. farcinica, providing a scientific basis for clinical antibiotic use and controlling the spread of resistant strains.MethodsWe analyzed 20 N. farcinica strains.
Chenchen Si +5 more
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Journal of Pure and Applied Microbiology, 2022 AcrAB-TolC is a resistance nodulation division type of efflux pump present in Enterobacteriaceae. It non-specifically effluxes antibiotics out of the bacterial cell, thus conferring drug resistance.
Priyadharshini Sekar +3 more
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