Bacterial Efflux Pump Inhibitors Reduce Antibiotic Resistance
PharmaceuticsBacterial resistance is a growing problem worldwide, and the number of deaths due to drug resistance is increasing every year. We must pay great attention to bacterial resistance.
Kun Mi, Fengying Gong, Lingli Huang
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The crosstalk between efflux pump and resistance gene mutation in Helicobacter pylori
Gut MicrobesEfflux pumps play a crucial role in the development of antibiotic resistance. The aim of this study was to investigate the relationship between efflux pump gene expression and resistance gene mutations in Helicobacter pylori.
Huan Wang
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Microbiology Spectrum, 2023 NorA, an extensively studied efflux pump in Staphylococcus aureus, has been connected to fluoroquinolone, antiseptic, and disinfection resistance. Several studies have also emphasized how efflux pumps, including NorA, function as the first line of ...
Nishtha Chandal +2 more
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The RND Efflux Pump Gene Expression in the Biofilm Formation of Acinetobacter baumannii
Antibiotics, 2023 Multidrug resistant (MDR) Acinetobacter baumannii is a critical opportunistic pathogen in healthcare-associated infections (HAI). This is attributed to several factors, including its ability to develop biofilms that can enhance antimicrobial resistance ...
Ola A. Abd El-Rahman +4 more
doaj +2 more sources
A mass spectrometry-based assay for improved quantitative measurements of efflux pump inhibition. [PDF]
PLoS ONE, 2015 Bacterial efflux pumps are active transport proteins responsible for resistance to selected biocides and antibiotics. It has been shown that production of efflux pumps is up-regulated in a number of highly pathogenic bacteria, including methicillin ...
Adam R Brown +9 more
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A novel role for colistin as an efflux pump inhibitor in multidrug-resistant Klebsiella pneumoniae [PDF]
Scientific ReportsAntimicrobial resistance (AMR) is a global challenge that demands new strategies to maintain the effectiveness of current treatments. AMR arises through various mechanisms, including overexpression of drug efflux pumps. The AcrAB-TolC efflux pump is used
Rajnikant Sharma +7 more
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A Pseudomonas putida efflux pump acts on short-chain alcohols [PDF]
Biotechnology for Biofuels, 2018 Background The microbial production of biofuels is complicated by a tradeoff between yield and toxicity of many fuels. Efflux pumps enable bacteria to tolerate toxic substances by their removal from the cells while bypassing the periplasm.
Georg Basler +3 more
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Evolutionary loss of an antibiotic efflux pump increases Pseudomonas aeruginosa quorum sensing mediated virulence in vivo [PDF]
Nature CommunicationsAntibiotic resistance is a threat to human health, yet recent work highlights how loss of resistance may drive pathogenesis in some bacteria. In two recent studies, we found that β-lactam antibiotics and nutrient stresses faced during infection selected ...
Sheryl E. Fernandes +12 more
doaj +2 more sources
Antibiotics, 2019 Multidrug efflux systems play a prominent role in medicine, as they are important contributors to bacterial antibiotic resistance. NorA is an efflux pump transporter from the major facilitator superfamily that expels numerous drug compounds across the ...
Sandra G Zarate +2 more
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Evaluating the ciprofloxacin potentiation efficacy of repurposed drug flupentixol through efflux pump inhibition of pathogenic bacteria [PDF]
Scientific ReportsAntimicrobial resistance concerning burdens is increasing day by day. Efflux pump upregulation is one of the mechanisms through which bacteria develop resistance to antibiotics.
Md. Momin-Reza +7 more
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