Results 1 to 10 of about 405 (68)

Bacterial Efflux Pump Inhibitors Reduce Antibiotic Resistance

Pharmaceutics
Bacterial resistance is a growing problem worldwide, and the number of deaths due to drug resistance is increasing every year. We must pay great attention to bacterial resistance.
Lan Zhang, Xiaoyuan Tian, Lei Sun, Kun Mi, Ru Wang, Fengying Gong, Lingli Huang   +6 more
doaj   +3 more sources

Terpenes as bacterial efflux pump inhibitors: A systematic review

Frontiers in Pharmacology, 2022
Managing antibiotic resistance is a significant challenge in modern pharmacotherapy. While molecular analyses have identified efflux pump expression as an essential mechanism underlying multidrug resistance, the targeted drug development has occurred ...
Kaio Jefté Santos De Oliveira Dias, Gustavo Marinho Miranda, Jonatas Reis Bessa, Ana Carolina Justino De Araújo, Priscilla Ramos Freitas, Ray Silva De Almeida, Cícera Laura Roque Paulo, José Bezerra De Araújo Neto, Henrique D. M. Coutinho, Jaime Ribeiro-Filho, Jaime Ribeiro-Filho   +10 more
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Contribution of different mechanisms to the resistance to fluoroquinolones in clinical isolates of Salmonella enterica

Brazilian Journal of Infectious Diseases, 2013
Objectives: To study the potential factors include gene mutation, efflux pump and alteration of permeability associated with quinolone-resistance of Salmonella enterica strains isolated from patients with acute gastroenteritis and to evaluate the degree ...
Abeer Ahmed Rushdy, Mona Ibrahim Mabrouk, Ferialla Abdel-Hamid Abu-Sef, Zeinab Hassan Kheiralla, Said Mohamed Abdel -All, Neveen Mohamed Saleh   +5 more
doaj   +3 more sources

Efflux pump inhibitory potential of indole derivatives as an arsenal against norA over-expressing Staphylococcus aureus

Microbiology Spectrum, 2023
NorA, an extensively studied efflux pump in Staphylococcus aureus, has been connected to fluoroquinolone, antiseptic, and disinfection resistance. Several studies have also emphasized how efflux pumps, including NorA, function as the first line of ...
Nishtha Chandal, Rushikesh Tambat, Ritu Kalia, Gautam Kumar, Nisha Mahey, Sanjay Jachak, Hemraj Nandanwar   +6 more
doaj   +1 more source

EFFLUX PUMPS AS A PHARMACOLOGICAL TARGET TO COMBAT ANTIBIOTIC RESISTANCE

Медична наука України, 2023
Backround. Antibiotic resistance is the resistance of bacteria to antimicrobial drugs to which they were previously sensitive. A particular danger is the spread of multidrug-resistant healthcare-associated infections of "ESKAPE" group.
M.V. Khaitovych
doaj   +1 more source

Function and Inhibitory Mechanisms of Multidrug Efflux Pumps

Frontiers in Microbiology, 2021
Multidrug efflux pumps are inner membrane transporters that export multiple antibiotics from the inside to the outside of bacterial cells, contributing to bacterial multidrug resistance (MDR). Postgenomic analysis has demonstrated that numerous multidrug
Kunihiko Nishino, Seiji Yamasaki, Ryosuke Nakashima, Martijn Zwama, Mitsuko Hayashi-Nishino   +4 more
doaj   +1 more source

Discovery of Novel Symmetrical 1,4-Dihydropyridines as Inhibitors of Multidrug-Resistant Protein (MRP4) Efflux Pump for Anticancer Therapy

Molecules, 2020
Despite the development of targeted therapies in cancer, the problem of multidrug resistance (MDR) is still unsolved. Most patients with metastatic cancer die from MDR.
Henry Döring, David Kreutzer, Christoph Ritter, Andreas Hilgeroth   +3 more
doaj   +1 more source

Multidrug Efflux Pumps in Bacteria and Efflux Pump Inhibitors

Postępy Mikrobiologii, 2022
Antimicrobial resistance is becoming a paramount health concern nowadays. The increasing drug resistance in microbes is due to improper medications or over usage of drugs. Bacteria develop many mechanisms to extrude the antibiotics entering the cell. The
Sreekantan Abhirami P., Rajan Pooja P., Mini Minsa, Kumar Praveen   +3 more
doaj   +1 more source

Susceptibility Tests and Predictions of Transporter Profile in Serratia Species

Microorganisms, 2022
Disinfectants and biosecurity are critically important to control microbial diseases. Resistance to disinfectants compromises sectors such as agriculture and healthcare systems.
Gunther J. Staats, Samantha J. Mc Carlie, Charlotte E. Boucher-van Jaarsveld, Robert R. Bragg   +3 more
doaj   +1 more source

A Molecular Modeling Approach to Identify Novel Inhibitors of the Major Facilitator Superfamily of Efflux Pump Transporters

Antibiotics, 2019
Multidrug efflux systems play a prominent role in medicine, as they are important contributors to bacterial antibiotic resistance. NorA is an efflux pump transporter from the major facilitator superfamily that expels numerous drug compounds across the ...
Sandra G. Zárate, Paula Morales, Katarzyna Świderek, Victor M. Bolanos-Garcia, Agatha Bastida   +4 more
doaj   +1 more source