Bacterial Efflux Pump Inhibitors Reduce Antibiotic Resistance [PDF]
PharmaceuticsBacterial resistance is a growing problem worldwide, and the number of deaths due to drug resistance is increasing every year. We must pay great attention to bacterial resistance.
Lan Zhang +6 more
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Terpenes as bacterial efflux pump inhibitors: A systematic review [PDF]
Frontiers in Pharmacology, 2022 Managing antibiotic resistance is a significant challenge in modern pharmacotherapy. While molecular analyses have identified efflux pump expression as an essential mechanism underlying multidrug resistance, the targeted drug development has occurred ...
Kaio Jefté Santos De Oliveira Dias +10 more
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Multidrug Efflux Pumps in Bacteria and Efflux Pump Inhibitors
Postępy Mikrobiologii, 2022 Antimicrobial resistance is becoming a paramount health concern nowadays. The increasing drug resistance in microbes is due to improper medications or over usage of drugs. Bacteria develop many mechanisms to extrude the antibiotics entering the cell. The
Sreekantan Abhirami P. +3 more
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Efflux Pump Inhibitors Against Nontuberculous Mycobacteria. [PDF]
Int J Mol Sci, 2020 Over the last years, nontuberculous mycobacteria (NTM) have emerged as important human pathogens. Infections caused by NTM are often difficult to treat due to an intrinsic multidrug resistance for the presence of a lipid-rich outer membrane, thus encouraging an urgent need for the development of new drugs for the treatment of mycobacterial infections ...
Rindi L.
europepmc +5 more sources
Types and Mechanisms of Efflux Pump Systems and the Potential of Efflux Pump Inhibitors in the Restoration of Antimicrobial Susceptibility, with a Special Reference to Acinetobacter baumannii [PDF]
PathogensBacteria express a plethora of efflux pumps that can transport structurally varied molecules, including antimicrobial agents and antibiotics, out of cells.
Kira M. Zack +2 more
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Exploring allosteric efflux pump inhibitors and the role of bacterial membrane potential in modulating drug resistance [PDF]
Frontiers in MicrobiologyMulti-drug resistance (MDR) bacteria pose a significant global health challenge, primarily driven by the activity of multi-drug efflux pumps and their intimate coupling to bacterial membrane bioenergetics.
Ajay Pratap Singh Hada +5 more
doaj +2 more sources
Chlorpromazine and Amitriptyline Are Substrates and Inhibitors of the AcrB Multidrug Efflux Pump
mBio, 2020 Efflux is an important mechanism in Gram-negative bacteria conferring multidrug resistance. Inhibition of efflux is an encouraging strategy to restore the antibacterial activity of antibiotics.
Elizabeth M. Grimsey +10 more
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Efflux pump inhibitors for bacterial pathogens: From bench to bedside. [PDF]
Indian J Med Res, 2019 With the advent of antibiotics, bacterial infections were supposed to be a thing of past. However, this instead led to the selection and evolution of bacteria with mechanisms to counter the action of antibiotics. Antibiotic efflux is one of the major mechanisms, whereby bacteria pump out the antibiotics from their cellular ...
Sharma A, Gupta VK, Pathania R.
europepmc +3 more sources
Effect of α-Bisabolol and Its β-Cyclodextrin Complex as TetK and NorA Efflux Pump Inhibitors in Staphylococcus aureus Strains [PDF]
Antibiotics, 2020 Efflux pumps are proteins present in the plasma membrane of bacteria, which transport antibiotics and other compounds into the extracellular medium, conferring resistance. The discovery of natural efflux pump inhibitors is a promising alternative. α-
Rafael Pereira da Cruz +14 more
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Efflux Pump Inhibitors in Controlling Antibiotic Resistance: Outlook under a Heavy Metal Contamination Context [PDF]
Molecules, 2023 Serge Michalet +2 more
exaly +2 more sources