Results 21 to 30 of about 944,221 (201)

Evaluation of Efflux-Mediated Resistance and Biofilm formation in Virulent Pseudomonas aeruginosa Associated with Healthcare Infections

Antibiotics, 2023
Pseudomonas aeruginosa is a significant pathogen identified with healthcare-associated infections. The present study evaluates the role of biofilm and efflux pump activities in influencing high-level resistance in virulent P.
Paul A. Akinduti, Onome W. George, Hannah U. Ohore, Olusegun E. Ariyo, Samuel T. Popoola, Adenike I. Adeleye, Kazeem S. Akinwande, Jacob O. Popoola, Solomon O. Rotimi, Fredrick O. Olufemi, Conrad A. Omonhinmin, Grace I. Olasehinde   +11 more
doaj   +1 more source

Efflux pump effects on Mycobacterium tuberculosis drug resistance

, 2023
<p>Resistance and tolerance to antituberculosis drugs have become serious problems in disease treatment. This multi-phase study investigated the contributions of efflux pumps to Mycobacterium tuberculosis drug resistance.
Coban, Ahmet Yilmaz, Valiyeva, Gumral, Durupinar, Belma   +2 more
core   +1 more source

Effects of two efflux pump inhibitors on the drug susceptibility of Riemerella anatipestifer isolates from China

Journal of Integrative Agriculture, 2016
The objective of this study was to verify the supposition that efflux might be involved in the drug resistance of Riemerella anatipestifer isolates. Two broad-spectrum efflux pump inhibitors, carbonyl cyanide 3-chlorophenylhydrazone (CCCP) and Phe-Arg-β ...
Ya-fei LI, Hong-xia JIANG, Rong XIANG, Na SUN, Ya-nan ZHANG, Li-qing ZHAO, Peng GU, Li-qiao WANG, Zhen-ling ZENG   +8 more
doaj   +1 more source

Evaluation of efflux pump inhibitory activity of some plant extracts and using them as adjuvants to potentiate the inhibitory activity of some antibiotics against Staphylococcus aureus

Open Veterinary Journal, 2023
Background: Antibiotic resistant pathogens became a real global threat for human and animal health. This needs to concentrate the efforts to minimise and control these organisms.
Dhama Alsallami, Amjed Alsultan, kadhim hassan abbas, Simon R. Clarke   +3 more
doaj   +1 more source

Antibiotic resistance assessment and multi-drug efflux pumps of Enterococcus faecium isolated from clinical specimens

Journal of Infection in Developing Countries, 2023
Introduction: Enterococcus faecium is a major cause of community and hospital-acquired infections. Due to limited options for infection with fluoroquinolones-resistant Enterococci, novel therapeutics are urgently needed.
Mehdi Mirzaii, Masoud Alebouyeh, Mohammad Bagher Sohrabi, Parisa Eslami, Mojgan Fazli, Maryam Ebrahimi, Parinaz HajiAsgarli, Marjan Rashidan   +7 more
doaj   +1 more source

Role of efflux pump inhibitor in decreasing antibiotic cross-resistance of Pseudomonas aeruginosa in a burn hospital in Iran

Journal of Infection in Developing Countries, 2016
Introduction: Multidrug resistance in Pseudomonas aeruginosa may be due to efflux pump overexpression. This study phenotypically examined the role of efflux pump inhibitors in decreasing antibiotic cross-resistance between beta-lactams, fluoroquinolones,
Mahshid Talebi-Taher, َAli Majidpour, Abbas Gholami, Samira Rasouli-Kouhi, Maryam Adabi   +4 more
doaj   +1 more source

Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis. [PDF]

PLoS ONE, 2012
Multidrug resistant (MDR) tuberculosis is caused by Mycobacterium tuberculosis resistant to isoniazid and rifampicin, the two most effective drugs used in tuberculosis therapy.
Diana Machado, Isabel Couto, João Perdigão, Liliana Rodrigues, Isabel Portugal, Pedro Baptista, Bruno Veigas, Leonard Amaral, Miguel Viveiros   +8 more
doaj   +1 more source

Novel Symmetrical Cage Compounds as Inhibitors of the Symmetrical MRP4-Efflux Pump for Anticancer Therapy [PDF]

, 2021
Within the last decades cancer treatment improved by the availability of more specifically acting drugs that address molecular target structures in cancer cells.
Andreas Hilgeroth, Henry Döring, Peter Werner, Kreutzer, David, Hilgeroth, Andreas, Werner, Peter, Ritter, Christoph A., David Kreutzer, Christoph A. Ritter, Döring, Henry   +9 more
core   +1 more source

An Investigation of Bacterial Efflux Pump Inhibitors

, 2022
Multidrug resistance in bacteria, defined as the ability of a bacterial strain to resist the killing effects of more than one antibiotic, represents a major threat to global healthcare.
Moses, Emilie Alice
core   +1 more source

Enhanced Efficacy of Ciprofloxacin and Tobramycin against Staphylococcus aureus When Combined with Corydalis Tuber and Berberine through Efflux Pump Inhibition

Antibiotics
One way that bacteria develop antibiotic resistance is by reducing intracellular antibiotic concentrations through efflux pumps. Therefore, enhancing the efficacy of antibiotics using efflux pump inhibitors provides a way to overcome this type of ...
Yena Seo, Minjun Kim, Tae-Jong Kim
doaj   +1 more source