Repurposing bioactive aporphine alkaloids as efflux pump inhibitors [PDF]
Fitoterapia, 2019 Extrusion of drugs or drug-like compounds through bacterial efflux pumps is a serious health issue that leads to loss in drug efficacy. Combinatorial therapies of low-efficacy drugs with efflux pump inhibitors may help to restore the activities of such drugs.
Avci, Fatma Gizem +9 more
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Enhanced efficacy of putative efflux pump inhibitor/antibiotic combination treatments versus MDR strains of Pseudomonas aeruginosa in a Galleria mellonella in vivo infection model [PDF]
, 2015 This work was supported by the University of St Andrews.Objectives: The objectives of this study were to compare the antibiotic susceptibility of Pseudomonas aeruginosa strains with increased efflux pump expression in vitro and in vivo and to use these ...
Adamson, Dougal +2 more
core +1 more source
Molecules, 2020 Despite the development of targeted therapies in cancer, the problem of multidrug resistance (MDR) is still unsolved. Most patients with metastatic cancer die from MDR.
Henry Döring +3 more
doaj +1 more source
Cholesterol acquisition by Mycobacterium tuberculosis [PDF]
, 2015 In this issue of Virulence, Ramon-Garcia et al. demonstrate the requirement of a mycobacterial efflux pump during growth on cholesterol.
Larrouy-Maumus, GJ
core +1 more source
Correlation of ciprofloxacin resistance with the AdeABC efflux system in Acinetobacter baumannii clinical isolates [PDF]
, 2014 Background: Acinetobacter baumannii is one of the most important pathogens capable of colonization in burn patients, leading to drug-resistant wound infections.
Ardebili, A., Lari, A.R., Talebi, M.
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Flavonoids as Novel Efflux Pump Inhibitors and Antimicrobials Against Both Environmental and Pathogenic Intracellular Mycobacterial Species. [PDF]
Molecules, 2020 Solnier J, Martin L, Bhakta S, Bucar F.
europepmc +2 more sources
Dissecting a complex chemical stress: chemogenomic profiling of plant hydrolysates. [PDF]
, 2013 The efficient production of biofuels from cellulosic feedstocks will require the efficient fermentation of the sugars in hydrolyzed plant material.
Arkin, Adam P +14 more
core +2 more sources
Susceptibility Tests and Predictions of Transporter Profile in Serratia Species
Microorganisms, 2022 Disinfectants and biosecurity are critically important to control microbial diseases. Resistance to disinfectants compromises sectors such as agriculture and healthcare systems.
Gunther J. Staats +3 more
doaj +1 more source
Antimicrobial Resistance in Neisseria gonorrhoeae: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting. [PDF]
, 2019 The goal of the Sexually Transmitted Infection Clinical Trial Group's Antimicrobial Resistance (AMR) in Neisseria gonorrhoeae (NG) meeting was to assemble experts from academia, government, nonprofit and industry to discuss the current state of research,
Bristow, Claire C +15 more
core +1 more source
Intravital Multiphoton Microscopy with Fluorescent Bile Salts in Rats as an In Vivo Biomarker for Hepatobiliary Transport Inhibition [PDF]
, 2018 The bile salt export pump (BSEP) is expressed at the canalicular domain of hepatocytes, where it mediates the elimination of monovalent bile salts into the bile.
Chen, Yuan +5 more
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