Results 11 to 20 of about 54,728 (292)
Chlorpromazine and Amitriptyline Are Substrates and Inhibitors of the AcrB Multidrug Efflux Pump
mBio, 2020 Efflux is an important mechanism in Gram-negative bacteria conferring multidrug resistance. Inhibition of efflux is an encouraging strategy to restore the antibacterial activity of antibiotics.
Elizabeth M. Grimsey +10 more
doaj +3 more sources
Selenocompounds as Novel Antibacterial Agents and Bacterial Efflux Pump Inhibitors. [PDF]
Molecules, 2019 Bacterial multidrug resistance is becoming a growing problem for public health, due to the development and spreading of bacterial strains resistant to antimicrobials. In this study, the antibacterial and multidrug resistance reversing activity of a series of seleno-carbonyl compounds has been evaluated.
Mosolygó T +10 more
europepmc +10 more sources
Flavonoids as Inhibitors of Bacterial Efflux Pumps [PDF]
Molecules, 2021 Flavonoids are widely occurring secondary plant constituents, and are abundant in vegetable and fruit diets as well as herbal medicines. Therapeutic treatment options for bacterial infections are limited due to the spread of antimicrobial resistances.
Martin Waditzer, Franz Bucar
openaire +3 more sources
Brazilian Journal of Infectious Diseases, 2013 Objectives: To study the potential factors include gene mutation, efflux pump and alteration of permeability associated with quinolone-resistance of Salmonella enterica strains isolated from patients with acute gastroenteritis and to evaluate the degree ...
Abeer Ahmed Rushdy +5 more
doaj +3 more sources
Microbiology Spectrum, 2023 NorA, an extensively studied efflux pump in Staphylococcus aureus, has been connected to fluoroquinolone, antiseptic, and disinfection resistance. Several studies have also emphasized how efflux pumps, including NorA, function as the first line of ...
Nishtha Chandal +6 more
doaj +1 more source
Plant-derived secondary metabolites as the main source of efflux pump inhibitors and methods for identification. [PDF]
J Pharm Anal, 2020 Seukep AJ +4 more
europepmc +2 more sources
Bacterial efflux pump inhibitors from natural sources [PDF]
Journal of Antimicrobial Chemotherapy, 2006 The rapid spread of bacteria expressing multidrug resistance (MDR) has necessitated the discovery of new antibacterials and resistance-modifying agents. Since the initial discovery of bacterial efflux pumps in the 1980s, many have been characterized in community- and hospital-acquired Gram-positive and Gram-negative pathogens, such as Staphylococcus ...
Stavri, Michael +2 more
openaire +3 more sources
Detection of tetracyclines and efflux pump inhibitors [PDF]
Antimicrobial Agents and Chemotherapy, 1993 Screening assays for the detection of tetracyclines and inhibitors of tetracycline efflux pumps are described. The tetracycline assay is based on the observation that the tetA(B) gene encoding the efflux pump of transposon Tn10 is induced by tetracycline.
D M, Rothstein +6 more
openaire +2 more sources
Function and Inhibitory Mechanisms of Multidrug Efflux Pumps
Frontiers in Microbiology, 2021 Multidrug efflux pumps are inner membrane transporters that export multiple antibiotics from the inside to the outside of bacterial cells, contributing to bacterial multidrug resistance (MDR). Postgenomic analysis has demonstrated that numerous multidrug
Kunihiko Nishino +4 more
doaj +1 more source
Effect of efflux pump inhibition on Pseudomonas aeruginosa transcriptome and virulence [PDF]
, 2017 Efflux pumps of the resistance-nodulation-cell-division (RND) family increase antibiotic resistance in many bacterial pathogens, representing candidate targets for the development of antibiotic adjuvants.
Baldelli, Valerio +8 more
core +2 more sources