Results 11 to 20 of about 26,521 (248)

Microbial Efflux Pump Inhibitors: A Journey around Quinoline and Indole Derivatives [PDF]

Molecules, 2021
Tommaso Felicetti, Stefano Sabatini, Giada Cernicchi   +2 more
exaly   +2 more sources

Flavonoids as Inhibitors of Bacterial Efflux Pumps [PDF]

Molecules, 2021
Flavonoids are widely occurring secondary plant constituents, and are abundant in vegetable and fruit diets as well as herbal medicines. Therapeutic treatment options for bacterial infections are limited due to the spread of antimicrobial resistances.
Martin Waditzer, Franz Bucar
openaire   +3 more sources

Flavonoids as Novel Efflux Pump Inhibitors and Antimicrobials Against Both Environmental and Pathogenic Intracellular Mycobacterial Species [PDF]

Molecules, 2020
Sanjib Bhakta, Liam Martin, Franz Bucar   +2 more
exaly   +2 more sources

Contribution of different mechanisms to the resistance to fluoroquinolones in clinical isolates of Salmonella enterica

Brazilian Journal of Infectious Diseases, 2013
Objectives: To study the potential factors include gene mutation, efflux pump and alteration of permeability associated with quinolone-resistance of Salmonella enterica strains isolated from patients with acute gastroenteritis and to evaluate the degree ...
Abeer Ahmed Rushdy, Mona Ibrahim Mabrouk, Ferialla Abdel-Hamid Abu-Sef, Zeinab Hassan Kheiralla, Said Mohamed Abdel -All, Neveen Mohamed Saleh   +5 more
doaj   +3 more sources

Efflux pump inhibitory potential of indole derivatives as an arsenal against norA over-expressing Staphylococcus aureus

Microbiology Spectrum, 2023
NorA, an extensively studied efflux pump in Staphylococcus aureus, has been connected to fluoroquinolone, antiseptic, and disinfection resistance. Several studies have also emphasized how efflux pumps, including NorA, function as the first line of ...
Nishtha Chandal, Rushikesh Tambat, Ritu Kalia, Gautam Kumar, Nisha Mahey, Sanjay Jachak, Hemraj Nandanwar   +6 more
doaj   +1 more source

EFFLUX PUMPS AS A PHARMACOLOGICAL TARGET TO COMBAT ANTIBIOTIC RESISTANCE

Медична наука України, 2023
Backround. Antibiotic resistance is the resistance of bacteria to antimicrobial drugs to which they were previously sensitive. A particular danger is the spread of multidrug-resistant healthcare-associated infections of "ESKAPE" group.
M.V. Khaitovych
doaj   +1 more source

Detection of tetracyclines and efflux pump inhibitors [PDF]

Antimicrobial Agents and Chemotherapy, 1993
Screening assays for the detection of tetracyclines and inhibitors of tetracycline efflux pumps are described. The tetracycline assay is based on the observation that the tetA(B) gene encoding the efflux pump of transposon Tn10 is induced by tetracycline.
D M, Rothstein, M, McGlynn, V, Bernan, J, McGahren, J, Zaccardi, N, Cekleniak, K P, Bertrand   +6 more
openaire   +2 more sources

Function and Inhibitory Mechanisms of Multidrug Efflux Pumps

Frontiers in Microbiology, 2021
Multidrug efflux pumps are inner membrane transporters that export multiple antibiotics from the inside to the outside of bacterial cells, contributing to bacterial multidrug resistance (MDR). Postgenomic analysis has demonstrated that numerous multidrug
Kunihiko Nishino, Seiji Yamasaki, Ryosuke Nakashima, Martijn Zwama, Mitsuko Hayashi-Nishino   +4 more
doaj   +1 more source

Discovery of Novel Symmetrical 1,4-Dihydropyridines as Inhibitors of Multidrug-Resistant Protein (MRP4) Efflux Pump for Anticancer Therapy

Molecules, 2020
Despite the development of targeted therapies in cancer, the problem of multidrug resistance (MDR) is still unsolved. Most patients with metastatic cancer die from MDR.
Henry Döring, David Kreutzer, Christoph Ritter, Andreas Hilgeroth   +3 more
doaj   +1 more source

Effectiveness of Efflux Pump Inhibitors as Biofilm Disruptors and Resistance Breakers in Gram-Negative (ESKAPEE) Bacteria [PDF]

Antibiotics, 2019
Khondaker Miraz Rahman, Jm Sutton, Sutton J Mark   +2 more
exaly   +2 more sources