Results 31 to 40 of about 63,241 (259)

Multidrug efflux pumps of Pseudomonas aeruginosa show selectivity for their natural substrates

Frontiers in Microbiology
Antibiotic-resistant Gram-negative bacteria are an increasing threat to human health. Strategies to restore antibiotic efficacy include targeting multidrug efflux pumps by competitive efflux pump inhibitors. These could be derived from natural substrates
Léna Mazza, Léna Mazza, Alexandre Bory, Alexandre Bory, Alexandre Luscher, Alexandre Luscher, Joachim Kloehn, Jean-Luc Wolfender, Jean-Luc Wolfender, Christian van Delden, Christian van Delden, Thilo Köhler, Thilo Köhler   +12 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Biochemistry of Bacterial Multidrug Efflux Pumps [PDF]

International Journal of Molecular Sciences, 2012
Bacterial pathogens that are multi-drug resistant compromise the effectiveness of treatment when they are the causative agents of infectious disease. These multi-drug resistance mechanisms allow bacteria to survive in the presence of clinically useful antimicrobial agents, thus reducing the efficacy of chemotherapy towards infectious disease ...
Kumar, Sanath, Varela, Manuel F.
openaire   +2 more sources

Efflux pumps and microbial biofilm formation

Infection, Genetics and Evolution, 2023
Biofilm-related infections are resistant forms of pathogens that are regarded as a medical problem, particularly due to the spread of multiple drug resistance. One of the factors associated with biofilm drug resistance is the presence of various types of efflux pumps in bacteria.
Mahdyeh Neghabi, Hajiagha, Hossein Samadi, Kafil   +1 more
openaire   +2 more sources

Exploring novel amides as efflux pump inhibitors for overcoming antibiotic resistance in multidrug-resistant Pseudomonas aeruginosa

Iranian Journal of Microbiology
Background and Objectives: Pseudomonas aeruginosa (P. aeruginosa), a multidrug-resistant bacterium, represents a considerable risk in healthcare environments owing to its capacity to induce various infections. The resistance of P.
Fahad Ullah, Maqsood Ali, Falak Niaz, Israr Ali Khan, Sher Wali Khan, Momin Khan, Rafaqat Ishaq, Abdul Manan, Ying Yu, Muhammad Ilyas   +9 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

The MRP family of drug efflux pumps [PDF]

Oncogene, 2003
The MRP family is comprised of nine related ABC transporters that are able to transport structurally diverse lipophilic anions and function as drug efflux pumps. Investigations of this family have provided insights not only into cellular resistance mechanisms associated with natural product chemotherapeutic agents, antifolates and nucleotide analogs ...
Gary D, Kruh, Martin G, Belinsky
openaire   +2 more sources

Xanthones Active against Multidrug Resistance and Virulence Mechanisms of Bacteria

Antibiotics, 2021
The emergence of multidrug and extensively drug-resistant pathogenic bacteria able to resist to the action of a wide range of antibiotics is becoming a growing problem for public health.
Fernando Durães, Diana I. S. P. Resende, Andreia Palmeira, Nikoletta Szemerédi, Madalena M. M. Pinto, Gabriella Spengler, Emília Sousa   +6 more
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Efflux pump-mediated resistance in chemotherapy

Annals of Medical and Health Sciences Research, 2012
Efflux pump mechanisms perform important physiological functions such as prevention of toxin absorption from the gastrointestinal tract, elimination of bile from the hepatocytes, effective functioning of the blood-brain barrier and placental barrier, and renal excretion of drugs.
Ughachukwu, PO, Unekwe, PC
openaire   +4 more sources