Cholesterol acquisition by Mycobacterium tuberculosis [PDF]
, 2015 In this issue of Virulence, Ramon-Garcia et al. demonstrate the requirement of a mycobacterial efflux pump during growth on cholesterol.
Larrouy-Maumus, GJ
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A cell-based infection assay identifies efflux pump modulators that reduce bacterial intracellular load. [PDF]
PLoS Pathogens, 2018 Bacterial efflux pumps transport small molecules from the cytoplasm or periplasm outside the cell. Efflux pump activity is typically increased in multi-drug resistant (MDR) pathogens; chemicals that inhibit efflux pumps may have potential for antibiotic ...
Abigail L Reens +8 more
doaj +1 more source
Correlation of ciprofloxacin resistance with the AdeABC efflux system in Acinetobacter baumannii clinical isolates [PDF]
, 2014 Background: Acinetobacter baumannii is one of the most important pathogens capable of colonization in burn patients, leading to drug-resistant wound infections.
Ardebili, A., Lari, A.R., Talebi, M.
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Effect of efflux pump inhibition on Pseudomonas aeruginosa transcriptome and virulence [PDF]
, 2017 Efflux pumps of the resistance-nodulation-cell-division (RND) family increase antibiotic resistance in many bacterial pathogens, representing candidate targets for the development of antibiotic adjuvants.
Baldelli, Valerio +8 more
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Using cellular fitness to map the structure and function of a major facilitator superfamily effluxer. [PDF]
, 2017 The major facilitator superfamily (MFS) effluxers are prominent mediators of antimicrobial resistance. The biochemical characterization of MFS proteins is hindered by their complex membrane environment that makes in vitro biochemical analysis challenging.
Bennett, Matthew R +5 more
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Brazilian Journal of Infectious Diseases, 2013 Objectives: To study the potential factors include gene mutation, efflux pump and alteration of permeability associated with quinolone-resistance of Salmonella enterica strains isolated from patients with acute gastroenteritis and to evaluate the degree ...
Abeer Ahmed Rushdy +5 more
doaj +3 more sources
Enhanced efficacy of putative efflux pump inhibitor/antibiotic combination treatments versus MDR strains of Pseudomonas aeruginosa in a Galleria mellonella in vivo infection model [PDF]
, 2015 This work was supported by the University of St Andrews.Objectives: The objectives of this study were to compare the antibiotic susceptibility of Pseudomonas aeruginosa strains with increased efflux pump expression in vitro and in vivo and to use these ...
Adamson, Dougal +2 more
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Detection of tetracyclines and efflux pump inhibitors [PDF]
Antimicrobial Agents and Chemotherapy, 1993 Screening assays for the detection of tetracyclines and inhibitors of tetracycline efflux pumps are described. The tetracycline assay is based on the observation that the tetA(B) gene encoding the efflux pump of transposon Tn10 is induced by tetracycline.
D M, Rothstein +6 more
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Mechanisms of RND multidrug efflux pumps [PDF]
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2009 RND (Resistance-Nodulation-Division) family transporters are widespread especially among Gram-negative bacteria, and catalyze the active efflux of many antibiotics and chemotherapeutic agents. They have very large periplasmic domains, and form tripartite complexes with outer membrane channels and periplasmic adaptor proteins.
Hiroshi, Nikaido, Yumiko, Takatsuka
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Journal of Infection in Developing Countries, 2023 Introduction: Enterococcus faecium is a major cause of community and hospital-acquired infections. Due to limited options for infection with fluoroquinolones-resistant Enterococci, novel therapeutics are urgently needed.
Mehdi Mirzaii +7 more
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