Results 131 to 140 of about 4,488,232 (311)

A Plant Photoregulator‐Inspired S‐Type Heterojunction System for Diabetic Keratopathy via Tri‐Modal Light‐Driven Immunometabolic Reprogramming, Tissue Repair, and Antibacterial Activity

Advanced Science, EarlyView.
To address the multifaceted imbalance in diabetic keratopathy, a light‐responsive biomimetic platform (WCNx‐Rh2) is developed and integrates glucose degradation, immune modulation, and antibacterial defense through a designed heterojunction and screened immunomodulator. WCNx‐Rh2 reduces AGEs/ROS and inflammatory signaling, reprogramming dendritic cells
Mengzhen Zhao, Zhibin Zhou, Yuxuan Wei, Xiangfan Huang, Zhiyong Zhou, Jiaheng Chen, Haoxin Cheng, Xiaotian Hu, Xiaolei Wang   +8 more
wiley   +1 more source

The importance of sample size in the determination of a flock-level antimicrobial resistance profile for Escherichia coli in broilers

, 2011
Determining herd- or flock-specific antimicrobial resistance profiles is important to guide therapeutic use of antimicrobials and to assess risk factors for the development and spread of antimicrobial resistance.
A. Smet, Jeroen Dewulf, P. Butaye, Boudewijn Catry, An Martel, Persoons, Davy, M. Heyndrickx, Annemieke Smet, Dewulf, Jeroen, Bollaerts, Kaatje, F. Haesebrouck, Persoons, DavyUGent001999096238802000105019975254989144F899BE38-F0ED-11E1-A9DE-61C894A0A6B4, Heyndrickx, MarcDI058010005656870000-0002-2913-26862DFF7EC8-F0EE-11E1-A9DE-61C894A0A6B4, Martel, AnDI058010014327280000-0001-7609-5649F5F50C8C-F0ED-11E1-A9DE-61C894A0A6B4, A. Martel, Lieve Herman, Martel, An, J. Dewulf, Catry, Boudewijn, Patrick Butaye, Marc Heyndrickx, K. Bollaerts, Butaye, Patrick, Davy Persoons, B. Catry, Haesebrouck, Freddy, Heyndrickx, Marc, L. Herman, Freddy Haesebrouck, D. Persoons, Herman, Lieve, Dewulf, JeroenCA05DI080019920941518010012560070000-0001-9843-5990F57DE986-F0ED-11E1-A9DE-61C894A0A6B4, Smet, AnnemiekeUGent0020001015038020001010769776015886900000-0001-9852-9137F897F832-F0ED-11E1-A9DE-61C894A0A6B4, Smet, Annemieke, Kaatje Bollaerts, Butaye, PatrickDI05801001126570F5276C1E-F0ED-11E1-A9DE-61C894A0A6B4, Haesebrouck, FreddyDI058010005165810000-0002-1709-933XF4151B78-F0ED-11E1-A9DE-61C894A0A6B4   +36 more
core   +1 more source

Fatty Acid Binding Protein 5 Mediates Astrocytic Pyroptosis and Neuroinflammation in Epilepsy via cGAS/STING Pathway

Advanced Science, EarlyView.
Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen, Yao Zhao, Yangye Lian, Yifei Hou, Lifen Gong, Tingting Wu, Yulin Yang, Jiaqi Zhu, Xin Wang, Kaihua Zhang, Jing Ding   +10 more
wiley   +1 more source

An exploration of the ocular mysteries linking nanoparticles to the patho-therapeutic effects against keratitis

Journal of Nanobiotechnology
Microbial keratitis, a sight-threatening corneal infection, remains a significant global health concern. Conventional therapies using antimicrobial agents often suffers from limitations such as poor drug penetration, side effects, and occurrence of drug ...
Siying Qu, Shuihua Zheng, Sibtain Muhammad, Liang Huang, Bing Guo   +4 more
doaj   +1 more source

Hygiene: microbial strategies to reduce pathogens and drug resistance in clinical settings

Microbial Biotechnology, 2017
Summary Healthcare‐associated infections ( HAI s) are a global concern, affecting all western hospitals, and profoundly impairing the clinical outcome of up to 15% of all hospitalized patients.
openaire   +2 more sources

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Advanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta, Shuyi Wang, Boyan Zhang, Ning Liu, Yingchen Han, Aoran Liu, Ying Xu, Tingsong Chen, Ye Zhang, Qiuhua Luo, Tao Han   +10 more
wiley   +1 more source

Microbial spectrum and drug-resistance profile of isolates causing bloodstream infections in febrile cancer patients at a referral hospital in Addis Ababa, Ethiopia

Infection and Drug Resistance, 2018
Balew Arega,1,2 Yimtubezinash Woldeamanuel,2 Kelemework Adane,3 Abdulaziz A Sherif,4 Daniel Asrat2 1College of Health Sciences, Debre Markos University, Debre Markos, 2Department of Microbiology, Immunology, and Parasitology, School of Medicine, College ...
Arega B, Woldeamanuel Y, Adane K, Sherif AA, Asrat D   +4 more
doaj  

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Prevalence of Over-the-counter use of Antibiotics among Patients visiting Outpatient Department of a Primary Health Centre: An Observational Study

Journal of Nepal Medical Association
Introduction: Antimicrobials are the most commonly used medicine. Over-the-counter use of antibiotics is more prevalent in developing countries, contributing to inappropriate use and increasing antimicrobial resistance.
Shova Sapkota, Kiran Shrestha, Parikshit Prasai, Mausam Thapa Magar, Ojaswee Karki   +4 more
doaj   +1 more source

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source