Angewandte Chemie, EarlyView.Gromomycins represent a novel class of pentacyclic triterpene antibiotics with a unique biosynthetic pathway independent of the squalene route. These compounds exhibit potent activity against drug‐resistant Gram‐positive pathogens, including MRSA, and their unprecedented cyclization mechanism provides new insight into bacterial triterpene biosynthesis.
Stepan Tistechok +11 more
wiley +2 more sources
Mechanisms of resistance against allylamine and azole antifungals in Trichophyton: A renewed call for innovative molecular diagnostics in susceptibility testing. [PDF]
PLoS PathogGupta AK +5 more
europepmc +1 more source
Advanced NanoBiomed Research, EarlyView.Microalgae are emerging as sustainable and economical bioresources that can be utilized as bioinks for creating constructs with intriguing functionalities. This review discusses the properties and applications of microalgae, providing a comprehensive review of recent advancements and challenges in 3D‐printed microalgae‐based constructs for various ...
Yiwei Zou +3 more
wiley +1 more source
Saarvienin A—A Novel Glycopeptide with Potent Activity against Drug‐Resistant Bacteria
Angewandte Chemie, EarlyView.A structurally distinct glycopeptide, saarvienin A, represents a new family of glycopeptide antibiotics consisting of five sugar/aminosugar units connected to a halogenated peptide core. Saarvienin A overcomes vancomycin resistance and shows strong activity against drug‐resistant Gram‐positive bacteria, in particular, high‐priority pathogens such as ...
Amninder Kaur +7 more
wiley +2 more sources
Comparative analysis of antibiotic resistance genes between fresh pig manure and composted pig manure in winter, China. [PDF]
PLoS OneHuang S, Xing M, Wang H.
europepmc +1 more source
Functional Synovium‐Based 3D Models in the Context of Human Disease and Inflammation
Advanced NanoBiomed Research, EarlyView.The synovium is key to joint function but is often affected by diseases like rheumatoid arthritis. Finding better treatments is challenging because current lab models do not fully mimic real tissues. New 3D technologies, like bioprinting, offer better methods to study these diseases, improve drug testing, and develop personalized treatments, bringing ...
Amelia Heslington +3 more
wiley +1 more source
Antibacterial Siderophores of Pandoraea Pathogens and Their Impact on the Diseased Lung Microbiota
Angewandte Chemie, EarlyView.Genome mining of environmental and pathogenic Pandoraea species identified a conserved NRPS gene cluster and led to the discovery of novel siderophores, pandorabactins, which exert their antibacterial activity by depleting iron from competitors. Bioinformatic analysis of sputum from cystic fibrosis patients coupled with bioassays indicates that ...
Elena Herzog +8 more
wiley +2 more sources
Comprehensive analysis of the pathogen spectrum and antibiotic resistance profiles in periprosthetic joint infections: a single center retrospective study. [PDF]
Front SurgCao Q +6 more
europepmc +1 more source
The Slow Pandemic: Emergence of Antimicrobial Resistance in the Postadvent of SARS-CoV-2 Pandemic. [PDF]
Glob Health Epidemiol GenomOsunla A +6 more
europepmc +1 more source
Green Nanotechnology: Naturally Sourced Nanoparticles as Antibiofilm and Antivirulence Agents Against Infectious Diseases. [PDF]
Int J MicrobiolLawal H +3 more
europepmc +1 more source