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Moonlighting proteins: beacon of hope in era of drug resistance in bacteria

Critical reviews in microbiology, 2022
Moonlighting proteins (MLPs) are ubiquitous and provide a unique advantage to bacteria performing multiple functions using the same genomic content. Targeting MLPs can be considered as a futuristic approach in fighting drug resistance problem.
Pramod Yadav   +5 more
semanticscholar   +1 more source

Use of Topical Colistin in Multiple Drug-Resistant Pseudomonas aeruginosa Bacterial Keratitis

Cornea, 2014
The aim of this study was to report the utility of topical colistin in multi-drug resistant Pseudomonas aeruginosa bacterial keratitis.Retrospective interventional case series included 8 patients with culture-proven multi-drug resistant P. aeruginosa (MDR-PA) bacterial keratitis who presented from June 2011 to January 2012 and were treated with ...
Rajat Jain   +3 more
openaire   +2 more sources

Coumarin-1,2,3-triazole Hybrid Molecules: An Emerging Scaffold for Combating Drug Resistance.

Current Topics in Medicinal Chemistry, 2021
No doubt antibiotics have saved billions of lives, but lack of novel antibiotics, development of resistance mechanisms in almost all clinical isolates of bacteria, and recurrent infections caused by persistent bacteria hamper the successful treatment of ...
H. Upadhyay
semanticscholar   +1 more source

An Overview of the Global Alarming Increase of Multiple Drug Resistant: A Major Challenge in Clinical Diagnosis.

Infectious Diseases - Drug Targets, 2023
The increased spreading of antibiotic resistance among different infectious agents has been a fast-growing public health challenge worldwide; this is because of the discovery of new resistance mechanisms and the reduction in quality and effective ...
J. A. Alara, O. R. Alara
semanticscholar   +1 more source

Role of integrons in the proliferation of multiple drug resistance in selected bacteria occurring in poultry production

British Poultry Science, 2019
1. The increase in microbial resistance, and in particular multiple drug resistance (MDR), is an increasing threat to public health. The uncontrolled use of antibiotics and antibacterial chemotherapeutics in the poultry industry, especially in ...
P. Racewicz   +4 more
semanticscholar   +1 more source

Antibacterial activity of two limonoids from Swietenia mahagoni against multiple-drug-resistant (MDR) bacterial strains

Journal of Natural Medicines, 2008
Solvent partitioning followed by column chromatography of the MeOH extract of the seeds of Swietenia mahagoni afforded two limonoids, swietenolide (1) and 2-hydroxy-3-O-tigloylswietenolide (2). The compounds were identified by spectroscopic means. The antibacterial activity of these compounds was assessed against eight multiple-drug-resistant bacterial
Husne-Ara Ali   +6 more
openaire   +3 more sources

Treatment of post-burns bacterial infections by Fenton reagent, particularly the ubiquitous multiple drug resistant Pseudomonas spp.

Medical Hypotheses, 2003
Post-burn microbial infections are a major problem in burns, and in cases of third degree burns, the survival of patients can depend not only upon the severity but also upon the extent and the type of infections. If proper measures are not employed, patients may suffer from opportunistic bacterial attacks, which can vary from simple infection, such as ...
O.G. Iranzo, Shamim I. Ahmad
openaire   +3 more sources

Reaction‐Induced Self‐Assembly of Polymyxin Mitigates Cytotoxicity and Reverses Drug Resistance

Advances in Materials
Polymyxins have been regarded as an efficient therapeutic against many life‐threatening, multidrug resistant Gram‐negative bacterial infections; however, the cytotoxicity and emergence of drug resistance associated with polymyxins have greatly hindered ...
Xiaowen Hu   +10 more
semanticscholar   +1 more source

Overview of Molecular Diagnostics in Multiple-Drug-Resistant Organism Prevention: Focus on Multiple-Drug-Resistant Gram-Negative Bacterial Organisms

2016
The combination of increasing rates of antibiotic resistance and the decreasing pace of new antibiotic development has become an urgent public health crisis (1). Multiple-drug-resistant bacterial organisms (MDROs) have now become common causes of health care-associated infection (HAI), the most prevalent being methicillin-resistant Staphylococcus ...
Daniel J. Diekema, Kaede V. Sullivan
openaire   +2 more sources

Novel Strategiesto Combat the Emerging Drug Resistance in Human Pathogenic Microbes.

Current Drug Targets, 2020
The major health-care burden for the developing world are the Infectious diseases and antimicrobial agents prove to be the magical drugs to combat this.
Hafsa Qadri, A. H. Shah, M. Mir
semanticscholar   +1 more source

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