Results 151 to 160 of about 283,019 (191)

Comparative Analysis of the Transcriptomic Response to Cisplatin in Drug-Sensitive and Drug-Resistant Testicular Germ Cell Tumors. [PDF]

Cancers (Basel)
Khan MW, Shokry D, Boyd RI, Singh R, Spinella MJ.   +4 more
europepmc   +1 more source

A comprehensive functional atlas of ALK kinase domain variants reveals resistance landscape to ALK inhibitors. [PDF]

Genome Biol
Oh HC, Han Y, Chang Y, Kim HH.
europepmc   +1 more source

Elacridar Reverses P-gp-Mediated Drug Resistance in Ovarian Cancer Cells in 2D and 3D Culture Models. [PDF]

Int J Mol Sci
Stasiak P, Sopel J, Lipowicz JM, Rawłuszko-Wieczorek AA, Sterzyńska K, Korbecki J, Januchowski R.   +6 more
europepmc   +1 more source

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ncRNAs associated with drug resistance and the therapy of digestive system neoplasms

Journal of Cellular Physiology, 2019
AbstractDigestive system cancer remains a common cancer and the main cause of cancer‐related death worldwide. Drug resistance is a major challenge in the therapy of digestive system cancer, and represents a primary obstacle in the treatment of cancer by restricting the efficiency of both traditional chemotherapy and biological therapies.
Wei Feng, Zhangyao Su, Qingqing Yin, Wei Zong, Xianjuan Shen, Shaoqing Ju   +5 more
openaire   +2 more sources

[Correlation between C219 and drug resistance in lung neoplasms].

Minerva medica, 1993
The authors take into consideration 19 cases of lung neoplasm to see the relationship of clinical behaviour and C219. They found a cutoff (25%) to separate drug resistant by drug sensibility. Marker sensitivity was 84.2% and relation with PCNA was negative (-0.384).
G, Oddi, G, De Angelis, M G, Alma, F, De Marinis, D, Bigioni   +4 more
openaire   +1 more source

The genetic origin of drug resistance in neoplasms: implications for systemic therapy.

Cancer research, 1984
Drug resistance continues to be a major factor in limiting the effectiveness of cancer chemotherapy. Evidence from a variety of sources implicates a genetic basis for most drug-resistant phenotypes. Assuming a random spontaneous origin for these resistant cells, it is possible to develop mathematical and computer-based models of the drug treatment of ...
J H, Goldie, A J, Coldman
openaire   +1 more source

Laboratory detection of primary and acquired drug resistance in human lymphatic neoplasms.

Cancer treatment reports, 1986
We tested the ability of the differential staining cytotoxicity (DiSC) assay to discriminate between sensitive and resistant cell populations in human lymphatic neoplasms. First, the in vitro activity spectra of the most important drugs paralleled the known clinical activity spectra of the same agents. Second, there were highly significant correlations
L M, Weisenthal, P L, Dill, J Z, Finklestein, T E, Duarte, J A, Baker, E M, Moran   +5 more
openaire   +1 more source

[Efficacy of surgical management combined with chemotherapy in the treatment of drug-resistant gestational trophoblastic neoplasm].

Zhonghua fu chan ke za zhi, 2011
To evaluate the efficacy of surgical management combined with chemotherapy in the treatment of drug-resistant gestational trophoblastic neoplasm (GTN) patients, and investigate factors influencing the outcome of the surgery combined with chemotherapy.Medical records of 42 patents with drug-resistant GTN who were treated by chemotherapy combined with ...
Feng-Zhi, Feng, Yang, Xiang, Yang, Cao, Lei, Li, Xi-Run, Wan, Xiu-Yu, Yang   +5 more
openaire   +1 more source