Results 251 to 260 of about 286,157 (290)

Role of CHD4 in tumor progression, DNA damage response and treatment resistance (Review). [PDF]

Oncol Rep
Li S, Ma Q, Lian K, Jiang Z, Ma Y.
europepmc   +1 more source

Role of the ETV5/p38 Signaling Axis in Aggressive Thyroid Cancer Cells. [PDF]

Mol Cancer Ther
Houl JH, Bagheri-Yarmand R, Kunnimalaiyaan M, Miranda Mendez P, Kidd JL, Dadbin A, Ruiz-Jurado A, Parekh PA, Henderson YC, Chari NS, Thennavan A, Powell RT, Stephan CC, Zhao X, Maniakas A, Nurieva R, Busaidy NL, Cabanillas ME, Dadu R, Zafereo M, Wang JR, Lai SY, Hofmann MC.   +22 more
europepmc   +1 more source

Case Report: Rare Multidrug-Resistant Enterobacter Cloacae Complicated by Invasive Pulmonary Aspergillosis in an Elderly Patient with Advanced Lung Adenocarcinoma Treated with Osimertinib. [PDF]

Infect Drug Resist
Zhou M, Shi J, Cao C, Zhang C.
europepmc   +1 more source

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ncRNAs associated with drug resistance and the therapy of digestive system neoplasms

Journal of Cellular Physiology, 2019
AbstractDigestive system cancer remains a common cancer and the main cause of cancer‐related death worldwide. Drug resistance is a major challenge in the therapy of digestive system cancer, and represents a primary obstacle in the treatment of cancer by restricting the efficiency of both traditional chemotherapy and biological therapies.
Wei Feng, Zhangyao Su, Qingqing Yin, Wei Zong, Xianjuan Shen, Shaoqing Ju   +5 more
openaire   +2 more sources

[Correlation between C219 and drug resistance in lung neoplasms].

Minerva medica, 1993
The authors take into consideration 19 cases of lung neoplasm to see the relationship of clinical behaviour and C219. They found a cutoff (25%) to separate drug resistant by drug sensibility. Marker sensitivity was 84.2% and relation with PCNA was negative (-0.384).
G, Oddi, G, De Angelis, M G, Alma, F, De Marinis, D, Bigioni   +4 more
openaire   +1 more source

The genetic origin of drug resistance in neoplasms: implications for systemic therapy.

Cancer research, 1984
Drug resistance continues to be a major factor in limiting the effectiveness of cancer chemotherapy. Evidence from a variety of sources implicates a genetic basis for most drug-resistant phenotypes. Assuming a random spontaneous origin for these resistant cells, it is possible to develop mathematical and computer-based models of the drug treatment of ...
J H, Goldie, A J, Coldman
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Laboratory detection of primary and acquired drug resistance in human lymphatic neoplasms.

Cancer treatment reports, 1986
We tested the ability of the differential staining cytotoxicity (DiSC) assay to discriminate between sensitive and resistant cell populations in human lymphatic neoplasms. First, the in vitro activity spectra of the most important drugs paralleled the known clinical activity spectra of the same agents. Second, there were highly significant correlations
L M, Weisenthal, P L, Dill, J Z, Finklestein, T E, Duarte, J A, Baker, E M, Moran   +5 more
openaire   +1 more source

INCB160058 selectively targets JAK2V617F-driven hematopoiesis in diverse and drug-resistant models of myeloproliferative neoplasms

Blood
Abstract INCB160058 is a first-in-class, orally bioavailable Janus kinase 2 (JAK2) V617F mutant-selective inhibitor, currently being studied in phase 1 clinical trials (eg, NCT06313593) in patients with myeloproliferative neoplasms (MPNs) harboring JAK2V617F mutation.
Hamza Celik, Gaurang Trivedi, Angelo Albertoni, Brittney Wass, Eddy Yue, Yanran Ai, Caroline Marty, Elodie Rosa, Maxime Evrard, William Vainchenker, Florence Pasquier, Cynthia Timmers, Sunkyu Kim, Ricardo Macarron, Isabelle Plo, Matthew Stubbs   +15 more
openaire   +1 more source

[Efficacy of surgical management combined with chemotherapy in the treatment of drug-resistant gestational trophoblastic neoplasm].

Zhonghua fu chan ke za zhi, 2011
To evaluate the efficacy of surgical management combined with chemotherapy in the treatment of drug-resistant gestational trophoblastic neoplasm (GTN) patients, and investigate factors influencing the outcome of the surgery combined with chemotherapy.Medical records of 42 patents with drug-resistant GTN who were treated by chemotherapy combined with ...
Feng-Zhi, Feng, Yang, Xiang, Yang, Cao, Lei, Li, Xi-Run, Wan, Xiu-Yu, Yang   +5 more
openaire   +1 more source

Perturbation of in vitro drug resistance in human lymphatic neoplasms by combinations of putative inhibitors of protein kinase C.

Cancer treatment reports, 1988
Fresh specimens of human lymphatic neoplasms were tested with the differential staining cytotoxicity assay. Cells from relapsed patients with acute lymphoblastic leukemia (ALL) were significantly more resistant to vincristine, dexamethasone, and doxorubicin in the assay than were cells from previously untreated patients.
L M, Weisenthal, Y Z, Su, T E, Duarte, P L, Dill, R A, Nagourney   +4 more
openaire   +1 more source