Results 301 to 310 of about 464,133 (328)

ncRNAs associated with drug resistance and the therapy of digestive system neoplasms

Journal of Cellular Physiology, 2019
AbstractDigestive system cancer remains a common cancer and the main cause of cancer‐related death worldwide. Drug resistance is a major challenge in the therapy of digestive system cancer, and represents a primary obstacle in the treatment of cancer by restricting the efficiency of both traditional chemotherapy and biological therapies.
Wei Feng, Zhangyao Su, Qingqing Yin, Wei Zong, Xianjuan Shen, Shaoqing Ju   +5 more
openaire   +3 more sources

[Efficacy of surgical management combined with chemotherapy in the treatment of drug-resistant gestational trophoblastic neoplasm].

Zhonghua fu chan ke za zhi, 2008
To evaluate the efficacy of surgical management combined with chemotherapy in the treatment of drug-resistant gestational trophoblastic neoplasm (GTN) patients, and investigate factors influencing the outcome of the surgery combined with chemotherapy.Medical records of 42 patents with drug-resistant GTN who were treated by chemotherapy combined with ...
Fengzhi Feng, Xiu-yu Yang, Lei Li, Xirun Wan, Yang Xiang, Yang Cao   +5 more
openaire   +3 more sources

Studies on drug resistance—I

Biochemical Pharmacology, 1969
Abstract A study of the physiological distribution of tritiated-1-β- d -arabinofuranosylcytosine ( 3 H-ara-C) in mice, carrying bilateral implants of ara-C-sensitive and -resistant tumors, indicated a selective, specific and prolonged accumulation of radio-activity in the sensitive tumor compared with the resistant tumor, liver, kidneys, spleen ...
Willi Kreis, Kiyohisa Uchida
openaire   +3 more sources

Therapeutic Perspective of Temozolomide Resistance in Glioblastoma Treatment

Cancer Investigation, 2021
Glioblastoma (GB) is the most lethal form of primary brain neoplasm. TMZ is the first-line standard treatment, but the strong resistance constrains the efficacy in clinical use.
Qin Xia, Liqun Liu, Yang Li, Pei Zhang, Da Han, Lei Dong   +5 more
semanticscholar   +1 more source

Tagraxofusp as treatment for patients with blastic plasmacytoid dendritic cell neoplasm

Expert Review of Anticancer Therapy, 2020
Introduction Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive hematologic malignancy that previously lacked standardized therapeutic approaches.
S. Lee, Deborah Mccue, N. Pemmaraju
semanticscholar   +1 more source

Role of cell adhesion molecules in invasion, anoikis resistance and drug resistance: An in vitro analysis using multiple phenotyping approach

, 2013
Epithelial ovarian carcinoma (EOC) is an aggressive neoplasm that mainly metastasizes to organs of the peritoneal cavity. This event is mediated by molecular mechanisms that remain elusive.
Thasni Karedath Abdul Azis
semanticscholar   +1 more source

Advances in Drug Delivery Systems for the Treatment of Acute Myeloid Leukemia.

Small
Acute myeloid leukemia (AML) is a common and catastrophic hematological neoplasm with high mortality rates. Conventional therapies, including chemotherapy, hematopoietic stem cell transplantation (HSCT), immune therapy, and targeted agents, have ...
Xia Wu, Fangfang Wang, Xijing Yang, Yuping Gong, Ting Niu, Bingyang Chu, Y. Qu, Zhiyong Qian   +7 more
semanticscholar   +1 more source

[Correlation between C219 and drug resistance in lung neoplasms].

Minerva medica, 1993
The authors take into consideration 19 cases of lung neoplasm to see the relationship of clinical behaviour and C219. They found a cutoff (25%) to separate drug resistant by drug sensibility. Marker sensitivity was 84.2% and relation with PCNA was negative (-0.384).
G, Oddi, G, De Angelis, M G, Alma, F, De Marinis, D, Bigioni   +4 more
openaire   +1 more source

Optimizing Drug Combinations for T-PLL: Restoring DNA Damage and P53-Mediated Apoptotic Responses.

Blood
T-prolymphocytic leukemia (T-PLL) is a mature T-cell neoplasm associated with marked chemotherapy resistance and continued poor clinical outcomes. Current treatments, i.e.
J. von Jan, S. Timonen, T. Braun, Qu Jiang, Aleksandr Ianevski, Yayi Peng, Kathleen McConnell, Paola Sindaco, T. Müller, S. Pützer, Hanna Klepzig, Dennis Jungherz, Annika Dechow, Linus Wahnschaffe, Anil K Giri, M. Kankainen, H. Kuusanmäki, H. Neubauer, R. Moriggl, P. Mazzeo, N. Schmidt, Raphael Koch, M. Hallek, A. Chebel, David Armisén, Laurent Genestier, E. Bachy, Anjali Mishra, A. Schrader, T. Aittokallio, S. Mustjoki, Marco Herling   +31 more
semanticscholar   +1 more source

The genetic origin of drug resistance in neoplasms: implications for systemic therapy.

Cancer research, 1984
Drug resistance continues to be a major factor in limiting the effectiveness of cancer chemotherapy. Evidence from a variety of sources implicates a genetic basis for most drug-resistant phenotypes. Assuming a random spontaneous origin for these resistant cells, it is possible to develop mathematical and computer-based models of the drug treatment of ...
J H, Goldie, A J, Coldman
openaire   +1 more source