Results 61 to 70 of about 273,925 (284)

Circular RNAs: key regulators of paclitaxel sensitivity and resistance in cancer

European Journal of Medical Research
Paclitaxel remains a cornerstone of cancer therapy, yet resistance significantly limits its clinical efficacy. Emerging evidence implicates circular RNAs (circRNAs) as key regulators of paclitaxel resistance, offering potential biomarkers and therapeutic
Zahra Tajik, Soudeh Ghafouri-Fard
doaj   +1 more source

3D Mass Spectrometry Imaging Reveals a Very Heterogeneous Drug Distribution in Tumors [PDF]

, 2016
Mass Spectrometry Imaging (MSI) is a widespread technique used to qualitatively describe in two dimensions the distribution of endogenous or exogenous compounds within tissue sections. Absolute quantification of drugs using MSI is a recent challenge that
M. D’Incalci, P. Veglianese, R. Frapolli, L. Falciola, S. Visentin, E. Davoli, S. . A. Licandro, S. Giordano, V. Pifferi, G. Cappelletti, L. Morosi, Visentin, Sonia, M. Zucchetti   +12 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling

, 2018
T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive neoplasm of mature T-cells with an urgent need for rationally designed therapies to address its notoriously chemo-refractory behavior. The median survival of T-PLL patients is
Pützer, S, Mustjoki, S, et al, Andersson, E I   +3 more
core   +2 more sources

Polyphenols and Chronic Myeloid Leukemia: Emerging Therapeutic Opportunities

Hemato
Background/Objectives: Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the BCR–ABL fusion gene, whose constitutive tyrosine kinase activity drives leukemogenesis.
Claudia Moriello, Chiara De Rosa, Stefania D’Angelo, Perrone Pasquale   +3 more
doaj   +1 more source

$\mathrm{C_{60}}$ fullerene enhances cisplatin anticancer activity and overcomes tumor cell drug resistance

, 2017
We formulated and analyzed a novel nanoformulation of the anticancer drug cisplatin (Cis) with C$_{60}$ fullerene (C$_{60}$+Cis complex) and showed its higher toxicity toward tumor cell lines in vitro when compared to Cis alone.
Garamus, Vasil, Buchelnikov, Anatoly, Panchuk, Rostyslav, Stoika, Rostyslav, Piosik, Jacek, Ritter, Uwe, Evstigneev, Maxim, Gołuński, Grzegorz, Skivka, Larysa, Hurmach, Vasyl, Skorohyd, Nadya, Berger, Walter, Scharff, Peter, Prylutskyy, Yuriy, Borowik, Agnieszka, Kyzyma, Olena, Prylutska, Svitlana, Woziwodzka, Anna, Bulavin, Leonid   +18 more
core   +1 more source

Bioinformatic Analysis for the Validation of Novel Biomarkers for Cancer Diagnosis and Drug Sensitivity [PDF]

, 2015
Background: The genetic control of tumour progression presents the opportunity for bioinformatics and gene expression data to be used as a basis for tumour grading.
Lockwood, Laura Anne Rebecca
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

JAK2 46/1 (GGCC) Haplotype in Oncogenesis, as Risk Stratifier, and Indicator for Drug Resistance in Myeloproliferative Neoplasms

International Journal of Molecular Sciences
The JAK2 46/1 (“GGCC”) haplotype is an inherited genetic variation within the Jak2 gene locus that has become a focal point in research related to oncogenesis, particularly in myeloproliferative neoplasms (MPNs). We conducted a narrative review of landmark discoveries in hematological malignancies and Jak2, focusing on its role in oncogenesis, risk ...
Michela Perrone, Sara Sergio, Beatrice Pranzo, Amalia Tarantino, Giuseppina Loglisci, Rosella Matera, Davide Seripa, Michele Maffia, Nicola Di Renzo   +8 more
openaire   +2 more sources