Results 41 to 50 of about 273,925 (284)

Current Advance of Therapeutic Agents in Clinical Trials Potentially Targeting Tumor Plasticity

Frontiers in Oncology, 2019
Tumor plasticity refers to tumor cell's inherent property of transforming one type of cell to different types of cells. Tumor plasticity is the main cause of tumor relapse, metastasis and drug resistance.
Xiao-Guang Yang, Lan-Cao Zhu, Yan-Jun Wang, Yan-Yu Li, Dun Wang   +4 more
doaj   +1 more source

Loss of KDM6A confers drug resistance in acute myeloid leukemia.

, 2020
Acute myeloid leukemia (AML) is an aggressive hematologic neoplasm resulting from the malignant transformation of myeloid progenitors. Despite intensive chemotherapy leading to initial treatment responses, relapse caused by intrinsic or acquired drug ...
Vick, B., Carlet, M., Greif, P.A., Hanneforth, A.L., Liu, W.-H., Schotta, G., Bartoschek, M.D., Rothenberg-Thurley, M., Domínguez Moreno, H., Mattes, R., Oettle, M., Ksienzyk, B., Hiddemann, W., Jeremias, I., Stief, S.M., Spiekermann, K., Weser, S., Kempf, J., Bultmann, S., Vosberg, S., Quentmeier, H., Metzeler, K.H., Tizazu, B., Leonhardt, H.   +23 more
core   +1 more source

The role of proton dynamics in the development and maintenance of multidrug resistance in cancer [PDF]

, 2013
With a projected 382.4 per 100,000 people expected to suffer from some form of malignant neoplasm in 2015, improving treatment is an essential focus of cancer research today. Multi-drug resistance (MDR) is the leading cause of chemotherapeutic failure in
Bell, Charlotte, Reshkinc, Stephan J., Harguindey, Salvador, Rauch, Cyril, Harguindey S, Rauch C., Bell C, Daniel, Chlo�, RESHKIN, Stephan Joel, Burton C, Reshkin, Stephan J., Burton, Christopher, Daniel C, Daniel, Chloë   +13 more
core   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Clinical resistance to platinum chemotherapy in ovarian cancer [PDF]

, 2009
Platinum drugs are the most active agents in ovarian cancer. Their cytotoxicty results from DNA crosslinking. High tumour response rates are seen, but 80 % of patients relapse. Major mechanisms of platinum resistance in patients remain to be established.
Newton, C., Newton, C
core  

An update on molecular biology and drug resistance mechanisms of multiple myeloma

, 2015
Multiple myeloma (MM), a neoplasm of plasma cells, is the second most common hematological malignancy. Incidance rates increase after age 40. MM is most commonly seen in men and African-American population.
Yağmur Kiraz, Baran, Yusuf, Yusuf Baran, Pelin Mutlu, Kiraz, Yağmur, Ufuk Gündüz, Mutlu, Pelin, Gündüz, Ufuk   +7 more
core   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Mitochondrion: Main organelle in orchestrating cancer escape from chemotherapy

Cancer Reports
Background Chemoresistance is a challenging barrier to cancer therapy, and in this context, the role of mitochondria is significant. We put emphasis on key biological characteristics of mitochondria, contributing to tumor escape from various therapies ...
Samaneh Mostafavi, Nahid Eskandari
doaj   +1 more source

Research advances in platinum resistance and its treatment in ovarian cancer [PDF]

精准医学杂志
Ovarian cancer is one of the most malignant gynecological tumors. Platinum-based chemotherapy is an important part of ovarian cancer treatment, with platinum resistance as a difficult problem in ovarian cancer treatment. Platinum resis-tance is a complex
LIU Yan, HUANG Li
doaj   +1 more source

The Role of Mesenchymal Stem Cells in Drug Resistance in Lung Neoplasms

Journal of Cancer Prevention
The tumor microenvironment (TME) is a decisive determinant of therapeutic response and the emergence of drug resistance in lung cancer. Among its stromal constituents, mesenchymal stem cells (MSCs) are pivotal regulators of disease progression because they secrete diverse paracrine mediators.
Dongho Kang, Eunhee Yeon, Sunyoung Kim, Eunjin Han, Taejo Kang, Hyekyung Song, Jiyoung Kim   +6 more
openaire   +2 more sources