Frontiers in Pharmacology, 2022 Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm, driven by the BCR-ABL1 fusion oncoprotein. The discovery of orthosteric BCR-ABL1 tyrosine kinase inhibitors (TKIs) targeting its active ATP-binding pocket, such as first-generation Imatinib
Hao Zhang +10 more
doaj +1 more source
Current Research on HIV Drug Resistance [PDF]
, 2022 HIV drug resistance is an unavoidable challenge for HIV/AIDS professionals, and it has long been a major obstacle hindering the global effort to contain HIV/AIDS.
core +1 more source
VIM-1, VIM-2, and GES-5 Carbapenemases Among Pseudomonas aeruginosa Isolates at a Tertiary Hospital in Istanbul, Turkey. [PDF]
, 2017 Worldwide increase in carbapenem resistance and transferable carbapenemases are significant challenges in treatment of Pseudomonas aeruginosa infections. In this study, investigation of carbapenemase production in carbapenem-resistant P.
Otlu, Barış +4 more
core +1 more source
Drug coverage in treatment of malaria and the consequences for resistance evolution--evidence from the use of sulphadoxine/pyrimethamine. [PDF]
, 2010 BACKGROUND\ud \ud It is argued that, the efficacy of anti-malarials could be prolonged through policy-mediated reductions in drug pressure, but gathering evidence of the relationship between policy, treatment practice, drug pressure and the evolution of ...
Abdulla, Salim +13 more
core +1 more source
Recent advances in targeted therapy of colorectal cancer: impacts of monoclonal antibodies nanoconjugates [PDF]
BioImpacts, 2019 Despite rapid advances in diagnostic and treatment approaches, the overall survival rate of cancer has not been improved. Colorectal cancer (CRC) is recognized as the third leading cause of neoplasm-related deaths worldwide, in large part due to its ...
Mostafa Akbarzadeh Khiavi +2 more
doaj +1 more source
Transferable drug resistance plasmids in fish-pathogenic bacteria [PDF]
, 2000 Chemotherapeutic agents have been developed for treating bacterial infections and have been widely used for cultured fish for the last 30 years in Japan.
Aoki, Takashi
core +1 more source
Epigenetics as a mechanism driving polygenic clinical drug resistance [PDF]
, 2006 Aberrant methylation of CpG islands located at or near gene promoters is associated with inactivation of gene expression during tumour development.
Glasspool, R.M. +8 more
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Current Advance of Therapeutic Agents in Clinical Trials Potentially Targeting Tumor Plasticity
Frontiers in Oncology, 2019 Tumor plasticity refers to tumor cell's inherent property of transforming one type of cell to different types of cells. Tumor plasticity is the main cause of tumor relapse, metastasis and drug resistance.
Xiao-Guang Yang +4 more
doaj +1 more source
PSMB7 Is a Key Gene Involved in the Development of Multiple Myeloma and Resistance to Bortezomib
Frontiers in Oncology, 2021 Multiple myeloma (MM), the second most commonly diagnosed hematologic neoplasm, is the most significant clinical manifestation in a series of plasma cell (PC) dyscrasia.
Dong Wu +8 more
doaj +1 more source
The Role of Mesenchymal Stem Cells in Drug Resistance in Lung Neoplasms
Journal of Cancer PreventionThe tumor microenvironment (TME) is a decisive determinant of therapeutic response and the emergence of drug resistance in lung cancer. Among its stromal constituents, mesenchymal stem cells (MSCs) are pivotal regulators of disease progression because they secrete diverse paracrine mediators.
Dongho Kang +6 more
openaire +2 more sources