Results 31 to 40 of about 286,157 (290)

Protein-Functionalized Microgel for Multiple Myeloma Cells’ 3D Culture

Biomedicines, 2022
Multiple myeloma is a hematologic neoplasm caused by an uncontrolled clonal proliferation of neoplastic plasma cells (nPCs) in the bone marrow. The development and survival of this disease is tightly related to the bone marrow environment.
Juan Carlos Marín-Payá, Sandra Clara-Trujillo, Lourdes Cordón, Gloria Gallego Ferrer, Amparo Sempere, José Luis Gómez Ribelles   +5 more
doaj   +1 more source

Strategic therapeutic approaches to overcome emerging dual SRC/ABL kinase inhibitors resistances in chronic phase Ph positive chronic myeloid leukemia

Asian Journal of Medical Sciences, 2014
Chronic myeloid leukemia (CML) is a haematopoietic neoplasm with clinically distinct phases and BCR⁄ABL1 oncogene. Imatinib mesylate, a potent inhibitor of BCR-ABL was highly effective in CML but later in-vitro derived cell line with resistance namely ...
Rajat Rana
doaj   +1 more source

Mcl-1 Inhibition: Managing Malignancy in Multiple Myeloma

Frontiers in Pharmacology, 2021
Multiple myeloma (MM) is a plasma cells neoplasm. The overexpression of Bcl-2 family proteins, particularly myeloid cell leukemia 1 (Mcl-1), plays a critical role in the pathogenesis of MM.
Omar S. Al-Odat, Omar S. Al-Odat, Max von Suskil, Max von Suskil, Robert J. Chitren, Robert J. Chitren, Weam O. Elbezanti, Weam O. Elbezanti, Sandeep K. Srivastava, Tulin Budak-Alpddogan, Subash C. Jonnalagadda, Bharat B. Aggarwal, Manoj Pandey   +12 more
doaj   +1 more source

Efficacy of adalimumab as second-line therapy in a pediatric cohort of crohn’s disease patients who failed infliximab therapy: The Italian society of pediatric gastroenterology, hepatology, and nutrition experience [PDF]

, 2019
Background: Adalimumab (Ada) treatment is an available option for pediatric Crohn’s disease (CD) and the published experience as rescue therapy is limited.
Accomando S., Aloi M., Alvisi P., Arrigo S., Balzani L., Cucchiara S., De Giacomo C., Gennari M., Guariso G., Knafelz D., Lionetti P., Martelossi S., Miele E., Ravelli A., Romano C., Zuin G.   +15 more
core   +1 more source

Essential procedures of single-cell RNA sequencing in multiple myeloma and its translational value

Blood Science, 2023
Multiple myeloma (MM) is a malignant neoplasm characterized by clonal proliferation of abnormal plasma cells. In many countries, it ranks as the second most prevalent malignant neoplasm of the hematopoietic system.
Jun Du, Xiao-Ran Gu, Xiao-Xiao Yu, Yang-Jia Cao, Jian Hou   +4 more
doaj   +1 more source

Common features between neoplastic and preneoplastic lesions of the biliary tract and the pancreas [PDF]

, 2019
The bile duct system and pancreas show many similarities due to their anatomical proximity and common embryological origin. Consequently, preneoplastic and neoplastic lesions of the bile duct and pancreas share analogies in terms of molecular ...
Alvaro, D, Arcidiacono, Pg, Capurso, G., Cardinale, V, Carpino, G, Doglioni, C, Gaudio, E, Pedica, F, Petrone, Mc, Severi, C, Zaccari, P   +10 more
core   +1 more source

Is porto sinusoidal vascular disease to be actively searched in patients with portal vein thrombosis? [PDF]

, 2019
Porto sinusoidal vascular liver disease (PSVD) and portal vein thrombosis (PVT) are distinct vascular liver diseases characterized, respectively, by an intrahepatic and a prehepatic obstacle to the flow in the liver portal system. PVT may also occur as a
D'Amati, G., Gioia, S., Nardelli, S., Ridola, L., Riggio, O.   +4 more
core   +1 more source

Mechanistic Insights Into Co-Administration of Allosteric and Orthosteric Drugs to Overcome Drug-Resistance in T315I BCR-ABL1

Frontiers in Pharmacology, 2022
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm, driven by the BCR-ABL1 fusion oncoprotein. The discovery of orthosteric BCR-ABL1 tyrosine kinase inhibitors (TKIs) targeting its active ATP-binding pocket, such as first-generation Imatinib
Hao Zhang, Hao Zhang, Mingsheng Zhu, Mingzi Li, Duan Ni, Yuanhao Wang, Liping Deng, Kui Du, Shaoyong Lu, Hui Shi, Chen Cai   +10 more
doaj   +1 more source

Dipeptidylpeptidase IV (CD26) defines leukemic stem cells (LSC) in chronic myeloid leukemia [PDF]

, 2014
Chronic myeloid leukemia (CML) is a stem cell (SC) neoplasm characterized by the BCR/ABL1 oncogene. Although mechanisms of BCR/ABL1-induced transformation are well-defined, little is known about effector-molecules contributing to malignant expansion and ...
Bilban, Martin, Blatt, Katharina, Cerny-Reiterer, Sabine, Herndlhofer, Susanne, Herrmann, Harald, Hoermann, Grego, Holyoake, Tessa L., Mannhalter, Christine, Mayerhofer, Matthias, Rulicke, Thomas, Sadovnik, Irina, Sperr, Wolfgang R., Stefanzl, Gabriele, Streubel, Berthold, Valent, Peter, Willmann, Michael   +15 more
core   +1 more source

Recent advances in targeted therapy of colorectal cancer: impacts of monoclonal antibodies nanoconjugates [PDF]

BioImpacts, 2019
Despite rapid advances in diagnostic and treatment approaches, the overall survival rate of cancer has not been improved. Colorectal cancer (CRC) is recognized as the third leading cause of neoplasm-related deaths worldwide, in large part due to its ...
Mostafa Akbarzadeh Khiavi, Azam Safary, Mohammad Hossein Somi   +2 more
doaj   +1 more source