Results 21 to 30 of about 273,925 (284)

Electrochemotherapy: An Alternative Strategy for Improving Therapy in Drug-Resistant SOLID Tumors

, 2022
Electrochemotherapy (ECT) is one of the innovative strategies to overcome the multi drug resistance (MDR) that often occurs in cancer. Resistance to anticancer drugs results from a variety of factors, such as genetic or epigenetic changes, an up ...
Gloria D’Avack, Maria Condello, Stefania Meschini, Spugnini, Enrico Pierluigi, Meschini, Stefania, Enrico Pierluigi Spugnini, Condello, Maria, D’Avack, Gloria   +7 more
core   +1 more source

Metabolic Reprogramming in Thyroid Cancer [PDF]

Endocrinology and Metabolism
Thyroid cancer is a common endocrine malignancy with increasing incidence globally. Although most cases can be treated effectively, some cases are more aggressive and have a higher risk of mortality.
Sang-Hyeon Ju, Minchul Song, Joung Youl Lim, Yea Eun Kang, Hyon-Seung Yi, Minho Shong   +5 more
doaj   +1 more source

Drug Resistance in Osteosarcoma: Emerging Biomarkers, Therapeutic Targets and Treatment Strategies

, 2021
High-grade osteosarcoma (HGOS), the most common primary malignant tumor of bone, is a highly aggressive neoplasm with a cure rate of approximately 40–50% in unselected patient populations.
Leonardo Fantoni, Massimo Serra, Hattinger, C. M., Serra, M., Patrizio, M. P., Chiara Riganti, Riganti, C., Chiara Casotti, Maria Pia Patrizio, Fantoni, L., Casotti, C., Claudia Maria Hattinger   +11 more
core   +1 more source

Advances in research on the relationship between thymoquinone and pancreatic cancer

Frontiers in Oncology, 2023
Pancreatic cancer has one of the worst prognoses among the most common cancers in the world. Its characteristics include a high rate of metastasis and chemotherapeutic resistance, which present major challenges to the medical community.
Zhanxue Zhao, Zhanxue Zhao, Linxun Liu, Shuai Li, Xiaofan Hou, Jinyu Yang   +5 more
doaj   +1 more source

Chemotherapy-induced dynamic gene expression changes in vivo are prognostic in ovarian cancer [PDF]

, 2014
This work was supported by Medical Research Scotland (FRG353 to VAS), the FP7-Directorate-General for Research and Innovation of the European Commission (EU HEALTH-F4-2012-305033 to Coordinating Action Systems Medicine to DJH); the Chief Scientist Office
A Koussounadis, Langdon, S. P., Koussounadis, A, S P Langdon, D J Harrison, Smith, V A, Harrison, D. J., Harrison, D J, Koussounadis, A., Smith, V Anne, Langdon, S P, V A Smith   +11 more
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Cancer chemotherapy resistance: Mechanisms and recent breakthrough in targeted drug delivery

, 2023
Conventional chemotherapy, one of the most widely used cancer treatment methods, has serious side effects, and usually results in cancer treatment failure. Drug resistance is one of the primary reasons for this failure.
Marco Cordani, Ghavami, Saeid, Cordani, Marco, Sarhadi, Mohammad, Davodabadi, Fatemeh, Samin Khosravi, Khosravi, Samin, Seyedeh Fatemeh Sajjadi, Shaghayegh Mirghasemi, Andani, Mahdieh Kamali, Fatemeh Davodabadi, Mahdieh Kamali Andani, Basiri, Mohsen, Hezaveh, Mahdieh Nadali, Mahdieh Nadali Hezaveh, Mohammad Sarhadi, Mohsen Basiri, Sajjadi, Seyedeh Fatemeh, Mirghasemi, Shaghayegh, Saeid Ghavami   +19 more
core   +1 more source

Cooperative Drug Combinations Target Oncogenes and Tumor Suppressors in Cancer

, 2021
Multiple myeloma (MM) is a neoplasm involving plasma cells in the bone marrow. Drug resistance and progression are common, underscoring the need for new drug combinations.
Tyler John Peat (11790659)
core   +2 more sources

Characterization of cyclin E expression in multiple myeloma and its functional role in seliciclib-induced apoptotic cell death. [PDF]

PLoS ONE, 2012
Multiple Myeloma (MM) is a lymphatic neoplasm characterized by clonal proliferation of malignant plasma cell that eventually develops resistance to chemotherapy.
Liat Josefsberg Ben-Yehoshua, Katia Beider, Avichai Shimoni, Olga Ostrovsky, Michal Samookh, Amnon Peled, Arnon Nagler   +6 more
doaj   +1 more source

The HGF/c-MET axis as a potential target to overcome survival signals and improve therapeutic efficacy in multiple myeloma

, 2021
Multiple myeloma (MM) accounts for about 10% of hematologic malignancies, and it is the second most frequent hematologic neoplasm after lymphomas. The exact etiology of MM is still unknown and, despite the introduction of more effective and safe drugs in
Daniela de Totero, de Totero, Daniela, Paolo Giannoni, Giannoni, Paolo   +3 more
core   +1 more source

Identification of the Interaction between P-Glycoprotein and Anxa2 in Multidrug-resistant Human Breast Cancer Cells

Cancer Biology & Medicine, 2012
Objective To explore the interaction of Anxa2 with P-Glycoprotein (P-gp) in the migration and invasion of the multidrug-resistant (MDR) human breast cancer cell line MCF-7/ADR.Methods A pair of short hairpin RNA (shRNA) targeting P-gp was transfected ...
Hai-chang Zhang, Fei Zhang, Bing Wu, Jing-hua Han, Wei Ji, Yan Zhou, Rui-fang Niu   +6 more
doaj   +1 more source