Explaining risk factors for drug-resistant tuberculosis in England and Wales: contribution of primary and secondary drug resistance [PDF]
, 2004 Drug-resistant tuberculosis can be transmitted (primary) or develop during the course of treatment (secondary). We investigated risk factors for each type of resistance.
Glynn, JR +5 more
core +1 more source
Cancer Biology & Medicine, 2012 Objective To explore the interaction of Anxa2 with P-Glycoprotein (P-gp) in the migration and invasion of the multidrug-resistant (MDR) human breast cancer cell line MCF-7/ADR.Methods A pair of short hairpin RNA (shRNA) targeting P-gp was transfected ...
Hai-chang Zhang +6 more
doaj +1 more source
Characterization of cyclin E expression in multiple myeloma and its functional role in seliciclib-induced apoptotic cell death. [PDF]
PLoS ONE, 2012 Multiple Myeloma (MM) is a lymphatic neoplasm characterized by clonal proliferation of malignant plasma cell that eventually develops resistance to chemotherapy.
Liat Josefsberg Ben-Yehoshua +6 more
doaj +1 more source
Asian Journal of Medical Sciences, 2014 Chronic myeloid leukemia (CML) is a haematopoietic neoplasm with clinically distinct phases and BCR⁄ABL1 oncogene. Imatinib mesylate, a potent inhibitor of BCR-ABL was highly effective in CML but later in-vitro derived cell line with resistance namely ...
Rajat Rana
doaj +1 more source
Protein-Functionalized Microgel for Multiple Myeloma Cells’ 3D Culture
Biomedicines, 2022 Multiple myeloma is a hematologic neoplasm caused by an uncontrolled clonal proliferation of neoplastic plasma cells (nPCs) in the bone marrow. The development and survival of this disease is tightly related to the bone marrow environment.
Juan Carlos Marín-Payá +5 more
doaj +1 more source
Drug resistance-conferring mutations in Mycobacterium tuberculosis from Madang, Papua New Guinea [PDF]
, 2012 : BACKGROUND: Monitoring drug resistance in Mycobacterium tuberculosis is essential to curb the spread of tuberculosis (TB). Unfortunately, drug susceptibility testing is currently not available in Papua New Guinea (PNG) and that impairs TB control in ...
Gagneux, S. +35 more
core +1 more source
Mcl-1 Inhibition: Managing Malignancy in Multiple Myeloma
Frontiers in Pharmacology, 2021 Multiple myeloma (MM) is a plasma cells neoplasm. The overexpression of Bcl-2 family proteins, particularly myeloid cell leukemia 1 (Mcl-1), plays a critical role in the pathogenesis of MM.
Omar S. Al-Odat +12 more
doaj +1 more source
Essential procedures of single-cell RNA sequencing in multiple myeloma and its translational value
Blood Science, 2023 Multiple myeloma (MM) is a malignant neoplasm characterized by clonal proliferation of abnormal plasma cells. In many countries, it ranks as the second most prevalent malignant neoplasm of the hematopoietic system.
Jun Du +4 more
doaj +1 more source
Molecular monitoring of HIV-1 drug resistance in Ifakara HIV-1 Cohort, Tanzania [PDF]
, 2013 HIV-1 resistance is one of the problems affecting success of antiretroviral therapy programmes worldwide. Many studies on efficacy of ART programmes, specifically on drug resistance, have been conducted in developed countries but not in developing ...
Masimba, Pax Jessey
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Drug resistance in metastatic castration-resistant prostate cancer: an update on the status quo [PDF]
, 2022 Prostate cancer (PCa) is a leading cause of cancer-related morbidity and mortality in men globally. Despite improvements in the diagnosis and treatment of PCa, a significant proportion of patients with high-risk localized disease and all patients with ...
Wakimian, Kevork +8 more
core +1 more source