Results 181 to 190 of about 4,670,790 (255)

2D Skeletal Muscle Thin Film Actuators Enhance Efficiency of Biohybrid Robots

Advanced Functional Materials, EarlyView.
2D skeletal muscle thin film actuators generate millinewton‐scale forces and millimeter‐scale strokes while remaining functional for over 30 days. Their force density is 20‐fold higher than 3D skeletal muscle actuators, enabling multi‐fin robots with tunable speed and multidirectional steering.
Maheera Bawa, Arielle Berman, Laura Schwendeman, Ferdows Afghah, Seanbiron Johnson, Ritu Raman   +5 more
wiley   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

A Comparative Evaluation of Four Bioinformatic Tools for Identifying HIV-1 <i>pol</i> Drug Resistance Mutations Using Illumina MiSeq Data. [PDF]

Biology (Basel)
Lee OF, Lee CK.
europepmc   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Hepatitis B immune escape and drug resistance mutations among blood donors in Gabon during the year 2022. [PDF]

Sci Rep
Maulot-Bangola D, Fokam J, Ngoufack Jagni Semengue E, Svicher V, Salpini R, Takou D, Beloumou GA, Etame NK, Mangala C, Djupsa Ndjeyep SC, Wamba AG, Sosso SM, Chenwi CA, Nka AD, Tchouaket Tommo MC, Fainguem N, Kamgaing R, Moor VA, Gonsu HK, Ekane GH, Awoh RA, Tayou C, Mbanya D, Zoung-Kanyi Bissek AC, Penlap V, Pellegrin OR, Nkoa T, Colizzi V, Ndembi N, Perno CF, Ndjolo A.   +30 more
europepmc   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

Zwitterionic Polymer Coating Enabled Chronic Dopamine Sensing and Electrophysiology Recording in Free‐Moving Mice

Advanced Healthcare Materials, EarlyView.
Application of a zwitterionic poly(sulfobetaine methacrylate) (PSB) coating to microelectrode arrays and Ag/AgCl reference electrodes effectively inhibits biofouling and structural degradation. This strategy successfully enables simultaneous, long‐term electrophysiological recording and dopamine sensing in freely behaving mice, facilitating ...
Bingchen Wu, Cort Thompson, Thomas Deakin, Yan Xu, Colleen A. McClung, Xinyan Tracy Cui   +5 more
wiley   +1 more source

Characterization of human immunodeficiency virus drug-resistance mutations among individuals with low-level-viremia in low-income and middle-income countries: A meta-analysis. [PDF]

World J Virol
El-Imam IA, Chenya UK, Mbishi JV, Peter TA, Mpimo BK, Ndembi N, Bakari HM, Mbwana MS, Fussi HF, Ally HM, Dababneh SW, Ramadhani HO.   +11 more
europepmc   +1 more source

A Hybrid Bioprinting–Microfabrication Approach to Controllable Multitype Spheroid Arrays for Modeling Tumor Heterogeneity

Advanced Healthcare Materials, EarlyView.
This work introduces a “cancer‐in‐a‐well” technology that recreates tumor heterogeneity in vitro using multitype spheroid arrays. Combining bioprinting/microdispensing with microstructured culture devices, the system improves drug screening and modeling of tumor complexity.
Simone Bonetti, Eva Clemente, Emanuela Mensà, Marco de Maria, Fulvia Farabegoli, Emanuela Saracino, Barbara Bortolani, Emanuela Marcelli, Renato Brandimarti, Dario de Biase, Giampaolo Zuccheri   +10 more
wiley   +1 more source

A national cross-sectional analysis of surveillance drug resistance mutations among recently diagnosed antiretroviral naïve Brazilian people with HIV. [PDF]

Lancet Reg Health Am
Caldeira DB, Constant Vergara TR, Schechter M, Bicudo EL, Freitas Lopes CA, Brites C, Sprinz E, Fernandes JC, Silveira OS, Durães-Carvalho R, Galinskas J, Treitsman MS, Gomes de Sousa MD, de Figueiredo Fernandes M, Helfer MS, Grilo NA, Caseiro MM, Sanz Duro RL, Bassini AS, Hunter JR, Janini LM, Diaz RS.   +21 more
europepmc   +1 more source