Results 91 to 100 of about 8,234,457 (404)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Incidence and Risk Factors for Serious Infections in Patients with Neuromyelitis Optica Spectrum Disorder: A Claims Database Study in Japan

Neurology and Therapy
Introduction Serious infection is a leading cause of mortality in patients with neuromyelitis optica spectrum disorder (NMOSD). We assessed the incidence of and risk factors for serious infections in patients with NMOSD.
Noriko Isobe, Tetsuro Oda, Tomohiro Yamaguchi, Yuta Kamei, Takahiko Tsumuraya, Akinori Yuri, Ayako Nakasone, Keiko Asao, Shinichi Matsuda   +8 more
doaj   +1 more source

Pan-cancer functional analysis of somatic mutations in G protein-coupled receptors

Scientific Reports, 2022
G Protein-coupled receptors (GPCRs) are the most frequently exploited drug target family, moreover they are often found mutated in cancer. Here we used a dataset of mutations found in patient samples derived from the Genomic Data Commons and compared it ...
B. J. Bongers, M. Gorostiola González, X. Wang, H. W. T. van Vlijmen, W. Jespers, H. Gutiérrez-de-Terán, K. Ye, A. P. IJzerman, L. H. Heitman, G. J. P. van Westen   +9 more
doaj   +1 more source

Drug safety and regulation [PDF]

BMJ, 2005
New powers and resources are needed I n the past few months, medical journals have published numerous editorials and news items relating to drug safety and regulation.1–3 The withdrawal of rofecoxib (Vioxx) has been the single biggest issue,4 but the cardiovascular safety of other cyclo-oxygenase-2 (COX 2) inhibitors5 and possible suicidal tendencies
Waller, Patrick C, Evans, Stephen JW, Beard, Keith   +2 more
openaire   +3 more sources

Stemming the Global Trade in Falsified and Substandard Medicines [PDF]

, 2013
Drug safety and quality is an essential assumption of clinical medicine, but there is growing concern that this assumption is not always correct. Poor manufacturing and deliberate fraud occasionally compromises the drug supply in the United States, and ...
Buckley, Gillian J., Gostin, Lawrence O., Kelley, Patrick W.   +2 more
core   +2 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Orally Administered 6:2 Chlorinated Polyfluorinated Ether Sulfonate (F-53B) Causes Thyroid Dysfunction in Rats

Toxics, 2020
The compound 6:2 chlorinated polyfluorinated ether sulfonate (F-53B), a replacement for perfluorooctanesulfonate (PFOS) in the electroplating industry, has been widely detected in numerous environmental matrices, human sera, and organisms.
So-Hye Hong, Seung Hee Lee, Jun-Young Yang, Jin Hee Lee, Ki Kyung Jung, Ji Hyun Seok, Sung-Hee Kim, Ki Taek Nam, Jayoung Jeong, Jong Kwon Lee, Jae-Ho Oh   +10 more
doaj   +1 more source

WORKPLACE SUBSTANCE USE, THE RISK OF OCCUPATIONAL INJURY, AND TESTING [PDF]

, 2005
Over the past 20 years, the "workplace substance abuse prevention industry" has grown enormously in size and has become more sophisticated in its marketing approach. Drug testing alone has become a $6 billion industry.
Zimbardi, Guy
core  

Systematic review of the safety of medication use in inpatient, outpatient and primary care settings in the Gulf Cooperation Council countries [PDF]

, 2018
Background Errors in medication use are a patient safety concern globally, with different regions reporting differing error rates, causes of errors and proposed solutions.
Abu Yassin, Abushaiqa, Ackroyd-Stolarz, Al Anany, Al Anazi, Al Hamid, Al Khaja, Al Khaja, Al Khaja, Al Khaja, Al Khaja, Al Odhayani, Al Rahbi, Al Shahaibi, Al-Arifi, Al-Arifi, Al-Dhawailie, Al-Ghamdi, Al-Hussein, Al-Jazairi, Al-Jeraisy, Al-Khani, Al-Olah, Al-Omar, Al-Rashdi, Al-Rowibah, Al-Tajir, Alakhali, Alanazi, Albarrak, Alghamdy, Aljadhey, Aljadhey, Aljadhey, Aljamal, Allan, Almazrou, Alshaikh, Alsulaimi, Altebenaui, American Geriatrics Society Beers Criteria Update Expert Panel, Arabi, Aseeri, ASHP, Bates, Bryony Dean Franklin, Cohen, Dean, Dean, Dean, Dean, Dibbi, Elnour, Ferner, Fick, Flynn, Flynn, Gandhi, Ghaleb, Ghaleb, Hemida, Hepler, Hisham Saad Aljadhey, Hooper, Insley, Irshaid, Jamilah Alsaidan, Jane Portlock, Jha, Jha, Kaushal, Kheir, Khoja, Landis, Lisby, Mahmoud, McLeod, McPhillips, Mendonca, Miller, Mitwally, Morimoto, Morimoto, Nada Atef Shebl, Naranjo, Nebeker, Neville, Rancourt, Rashed, Rashed, Rehmani, Sadat-Ali, Shaughnessy, Sonallah, WHO, World Bank   +95 more
core   +3 more sources

Liquid Hydroxyurea (Xromi) for Children With Sickle Cell Anemia: A New Solution Compounding Existing Problems

Pediatric Blood &Cancer, EarlyView.
Alexandra Power‐Hays, Charles T. Quinn
wiley   +1 more source