Results 111 to 120 of about 8,989,140 (356)

An MCEM Framework for Drug Safety Signal Detection and Combination from Heterogeneous Real World Evidence

open access: yesScientific Reports, 2018
Delayed drug safety insights can impact patients, pharmaceutical companies, and the whole society. Post-market drug safety surveillance plays a critical role in providing drug safety insights, where real world evidence such as spontaneous reporting ...
Cao Xiao   +4 more
semanticscholar   +1 more source

Youth Marijuana and Prescription Drug Abuse in Anchorage [PDF]

open access: yes, 2016
Complete issue of Alaska Justice Forum 33(1), Spring 2016 at https://scholarworks.alaska.edu/handle/11122/6883.This article examines results of the Adult Perceptions of Anchorage Youth: 2015 Survey (APAYS) to examine perceptions and concerns of Anchorage
Lepage, Cory R., Rivera, Marny
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Risk Perception and Drug Safety Evaluation [PDF]

open access: yes, 1991
The authors present a Risk communication framework based on a survey of empirical research concerning public Risk perceptions.
Vertinsky, Ilan B., Wehrung, Donald A.
core   +1 more source

Role of Computerized Physician Order Entry Usability in the Reduction of Prescribing Errors [PDF]

open access: yes, 2013
Some hospitals have implemented computerized physician order entry (CPOE) systems to reduce the medical error rates. However, research in this area has been very limited, especially regarding the impact of CPOE use on the reduction of prescribing errors.
Elhissi, Abdelbary   +4 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Orally Administered 6:2 Chlorinated Polyfluorinated Ether Sulfonate (F-53B) Causes Thyroid Dysfunction in Rats

open access: yesToxics, 2020
The compound 6:2 chlorinated polyfluorinated ether sulfonate (F-53B), a replacement for perfluorooctanesulfonate (PFOS) in the electroplating industry, has been widely detected in numerous environmental matrices, human sera, and organisms.
So-Hye Hong   +10 more
doaj   +1 more source

Docking-based virtual screening of known drugs against murE of Mycobacterium tuberculosis towards repurposing for TB. [PDF]

open access: yes, 2016
Repurposing has gained momentum globally and become an alternative avenue for drug discovery because of its better success rate, and reduced cost, time and issues related to safety than the conventional drug discovery process.
Brindha, Sridharan   +4 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Changing Course: A Review of the First Two Years of Drug Transfer Reform in Illinois [PDF]

open access: yes, 2008
Provides an overview of data on automatic transfers of fifteen- and sixteen-year-olds charged with certain drug offenses to adult courts, of reform efforts to repeal the transfer law, and of the immediate impact on juvenile caseloads and public ...
Elizabeth Kooy
core  

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