Results 91 to 100 of about 4,880,179 (312)

Monitoring antimalarial safety and tolerability in clinical trials: a case study from Uganda. [PDF]

, 2008
BACKGROUND: New antimalarial regimens, including artemisinin-based combination therapies (ACTs), have been adopted widely as first-line treatment for uncomplicated malaria.
Njama-Meya Denise, Staedke Sarah G, Catherine Maiteki-Sebuguzi, Sarah G Staedke, Denise Njama-Meya, Moses R Kamya, Kristin Banek, Maiteki-Sebuguzi Catherine, Grant Dorsey, Yeka Adoke, Jagannathan, Prasanna, Dorsey, Grant, Talisuna, Ambrose O, Arthur Mpimbaza, Dorsey Grant, Ambrose O Talisuna, Rosenthal Philip J, Hasifa Bukirwa, Jagannathan Prasanna, Maiteki-Sebuguzi, Catherine, Rosenthal, Philip J, Tamara D Clark, Clark Tamara D, Yeka, Adoke, Banek, Kristin, Nzarubara Bridget, Staedke, Sarah G, Prasanna Jagannathan, Banek Kristin, Mpimbaza Arthur, Bukirwa, Hasifa, Nzarubara, Bridget, Philip J Rosenthal, Njama-Meya, Denise, Clark, Tamara D, Adoke Yeka, Mpimbaza, Arthur, Kamya Moses R, Bridget Nzarubara, Kamya, Moses R, Bukirwa Hasifa, Wabwire-Mangen Fred, Talisuna Ambrose O, Fred Wabwire-Mangen, Wabwire-Mangen, Fred   +44 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Simultaneous Analysis of 272 Pesticides in Agricultural Products by the QuEChERS Method and Gas Chromatography with Tandem Mass Spectrometry

Molecules
The aim of this study is to develop a rapid and accurate method for simultaneous analysis of multi-residue pesticides and conduct pesticide monitoring in agricultural products produced by the production and distribution stage in Korea. The representative
Da-Young Yun, Ji-Yeon Bae, Yoon-Jung Kang, Chae-Uk Lim, Gui-Hyun Jang, Mi-Ok Eom, Won-Jo Choe   +6 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Transcriptomic and proteomic characterization of cell and protein biomarkers of checkpoint inhibitor-induced liver injury

Cancer Immunology, Immunotherapy
Immune checkpoint inhibitors (ICI) targeting CTLA-4 and PD-1 have shown remarkable antitumor efficacy, but can also cause immune-related adverse events, including checkpoint inhibitor-induced liver injury (ChILI).
Changhua Ji, Steven Kumpf, Jessie Qian, Joel D. Federspiel, Mark Sheehan, Darien Capunitan, Edmond Atallah, Stuart Astbury, Seda Arat, Elias Oziolor, Mireia Fernandez Ocana, Shashi K. Ramaiah, Jane Grove, Guruprasad P. Aithal, Thomas A. Lanz   +14 more
doaj   +1 more source

Development of a modified lymphocyte transformation test for diagnosing drug-induced liver injury associated with an adaptive immune response

Journal of Immunotoxicology, 2017
Drug-induced liver injury (DILI) is a growing problem. Diagnostic methods to differentiate DILI caused by an adaptive immune response from liver injury of other causes or to identify the responsible drug in patients receiving multiple drugs, herbals and ...
Jessica Whritenour, Mira Ko, Qing Zong, Jianying Wang, Karrie Tartaro, Patricia Schneider, Ellen Olson, Maria Van Volkenburg, Jose Serrano, Paul Hayashi, Robert Fontana, Naga Chalasani, Herbert L. Bonkovsky   +12 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Western Hemisphere Drug Policy Commission [website]

, 2021
Website of the Western Hemisphere Drug Policy Commission (WHDPC), charged to "evaluate a range of US counternarcotics programs in the Americas and then make recommendations to improve them" -- including a recording and transcript of the group's hearing ...
United States. Western Hemisphere Drug Policy Commission.
core  

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Countermeasures That Work: A Highway Safety Countermeasure Guide for State Highway Safety Offices, 11th Edition, 2023 [PDF]

DTNH22-17-D-00042The guide is a basic reference to assist State Highway Safety Offices (SHSOs) in selecting effective, evidence-based countermeasures for traffic safety problem areas.
Kirley, Bevan, Robison, Kristel, Brookshire, Kristen, O\u2019Brien, Natalie P., Goodwin, Arthur, University of North Carolina Highway Safety Research Center, Harmon, Katherine J, West, Alyson, Harrell, Stephanie, Thomas, Libby   +9 more
core