Results 91 to 100 of about 5,794,088 (264)
Medication safety in children [PDF]
, 2015 Background: The issue of medication safety has received considerable attention in the last few years. Especially drug related problems (DRP) are a major safety issue.
Glanzmann, C, Glanzmann, Corina
core +1 more source
Zhongguo aizheng zazhiClaudin 18.2 (CLDN18.2) has emerged as an important therapeutic target in gastrointestinal malignancies, particularly gastric cancer, adenocarcinoma of gastroesophageal junction, and pancreatic cancer.
Antitumor Drug Safety Management Professional Committee of Shanghai Anti-Cancer Association
doaj
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Alcohol and prescription drug safety in older adults
, 2013 Faika Zanjani,1,2 Aasha I Hoogland,1 Brian G Downer11Department of Gerontology, 2Building Interdisciplinary Research Careers in Women's Health University of Kentucky, Lexington, KY, USABackground: The objectives of this study were to investigate ...
Zanjani F, Hoogl, AI, Downer BG
core
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Countermeasures That Work: A Highway Safety Countermeasure Guide for State Highway Safety Offices, 11th Edition, 2023 [PDF]
DTNH22-17-D-00042The guide is a basic reference to assist State Highway Safety Offices (SHSOs) in selecting effective, evidence-based countermeasures for traffic safety problem areas.
Kirley, Bevan +9 more
core
Cancer Immunology, ImmunotherapyImmune checkpoint inhibitors (ICI) targeting CTLA-4 and PD-1 have shown remarkable antitumor efficacy, but can also cause immune-related adverse events, including checkpoint inhibitor-induced liver injury (ChILI).
Changhua Ji +14 more
doaj +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
The Development and Evaluation of Triage Algorithms for Early Discovery of Adverse Drug Interactions
, 2013 Background Around 20 % of all adverse drug reactions (ADRs) are due to drug interactions. Some of these will only be detected in the postmarketing setting.
Edwards, Ralph I., +8 more
core +1 more source
MoleculesThe aim of this study is to develop a rapid and accurate method for simultaneous analysis of multi-residue pesticides and conduct pesticide monitoring in agricultural products produced by the production and distribution stage in Korea. The representative
Da-Young Yun +6 more
doaj +1 more source