Results 281 to 290 of about 8,989,140 (356)

Lysosome‐Acidifying Nanoparticles Rescue A30P α‐Synuclein Induced Neuronal Death in Cellular and Drosophila Models of Parkinson's Disease

Advanced Healthcare Materials, EarlyView.
Lysosome‐targeted acidic nanoparticles based on a biodegradable poly(ethylene tetrafluorosuccinate‐co‐succinate) copolymer are engineered to restore impaired lysosomal acidification through pH‐responsive intracellular degradation. Localized acid release enhances autophagic proteolysis, reduces α‐synuclein accumulation, and preserves dopaminergic neuron
Chih Hung Lo, Mengda Ren, Gavin Wen Zhao Loi, Eka Norfaishanty Saipuljumri, Jonathan Indajang, Kah Leong Lim, Jialiu Zeng   +6 more
wiley   +1 more source

Functional 3D Human Neuron-Glioblastoma Model Reveals Cellular Interactions Enabling Drug Safety Assessments. [PDF]

FASEB J
Förster N, Isosaari L, Kulta O, Junnila O, Vuolanto V, Pollari M, Rautajoki KJ, Narkilahti S.   +7 more
europepmc   +1 more source

Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling

Advanced Healthcare Materials, EarlyView.
Emerging advances in three‐dimensional bioprinting and computational modeling are reshaping cardiovascular (CV) research by enabling more realistic, patient‐specific tissue platforms. This review surveys cutting‐edge approaches that merge biomimetic CV constructs with computational simulations to overcome the limitations of traditional models, improve ...
Tanmay Mukherjee, Mehdi Salar Amoli, Sarah Rezapourdamanab, Lama Rita El Shammas, Martin L. Tomov, Emilio A. Mendiola, Vahid Serpooshan, Reza Avazmohammadi   +7 more
wiley   +1 more source

Integrated Phenotypic and Genotypic Approaches for Accurate Diagnosis of G6PD Deficiency: Implications for Drug Safety in Thailand. [PDF]

Pharmacol Res Perspect
Pengsuk N, Chamchoy K, Duangdee C, Satayarak J, Saralamba N, Nguitragool W, Boonyuen U.   +6 more
europepmc   +1 more source

From prescription patterns to drug safety: a closer look at non-steroidal anti-inflammatory drugs and analgesics in outpatient pharmacy. [PDF]

Front Pharmacol
Saeed ZM, Sridhar SB, Shareef J, Rashed Alsereidi AM.   +3 more
europepmc   +1 more source

Advanced In Vitro Models for Preclinical Drug Safety: Recent Progress and Prospects. [PDF]

Curr Issues Mol Biol
Nair DG, Weiskirchen R.
europepmc   +1 more source

MHRA <i>Drug Safety Update</i> - topical steroids. [PDF]

Br J Gen Pract
Peacock D.
europepmc   +1 more source

An overview of drug-induced sodium channel blockade and changes in cardiac conduction: Implications for drug safety. [PDF]

Clin Transl Sci
Chaudhary KW, Clancy CE, Yang PC, Pierson JB, Goldin AL, Koerner JE, Wisialowski TA, Valentin JP, Imredy JP, Lagrutta A, Authier S, Kleiman R, Sager PT, Hoffmann P, Pugsley MK.   +14 more
europepmc   +1 more source

Editorial: Pharmacoepidemiology and pharmacovigilance post-marketing drug safety studies. [PDF]

Front Pharmacol
Khan Z, Karatas Y, Akici A, Martins MAP, Ahmad N.   +4 more
europepmc   +1 more source