Results 91 to 100 of about 37,916 (265)

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

The YAP-TEAD4 inhibitor M511-0965 suppresses triple-negative breast cancer progression by downregulating TGFB2

Translational Oncology
Triple-negative breast cancer (TNBC) lacks standard targeted therapies, and chemotherapy is associated with significant side effects and economic burden, highlighting the urgent need to develop novel low-toxicity and low-cost strategies.
Mengxing Cheng, Xinyu Li, Na Song, Xinxia Yang, Xiaolei Ma, Haocheng Zhang, Yating Lei, Yanxin Jia, Lina Ba, Ruipu Zhang, Lidan Bai, Wenxiao Xu, Guofen Qiao   +12 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Mathematical models characterising the kinetics and dynamics of topotecan to account for drug resistance mechanisms [PDF]

This thesis describes the use of mathematical modelling in studying the kinetics and dynamics of the anti-cancer agent topotecan (TPT), a semi-synthetic derivative of the natural extract camptothecin (CPT), which has been found to act as an inhibitor ...
Atari, M. I. (Mohammed Isam)
core  

Machine learning-aided discovery of T790M-mutant EGFR inhibitor CDDO-Me effectively suppresses non-small cell lung cancer growth

Cell Communication and Signaling
Background Epidermal growth factor receptor (EGFR) T790M mutation often occurs during long durational erlotinib treatment of non-small cell lung cancer (NSCLC) patients, leading to drug resistance and disease progression.
Rui Zhou, Ziqian Liu, Tongtong Wu, Xianwei Pan, Tongtong Li, Kaiting Miao, Yuru Li, Xiaohui Hu, Haigang Wu, Andrew M. Hemmings, Beier Jiang, Zhenzhen Zhang, Ning Liu   +12 more
doaj   +1 more source

Characterization of iron oxide nanoparticles for production of breast adenocarcinoma spheroids

Brazilian Journal of Radiation Sciences
The construction of an in vitro model that can accurately demonstrate the conditions found in vivo requires the production of a series of complexities that often transcend various areas of knowledge.
MAYELLE LIMA, Giovana Dias Silva, Patrícia, Thais, RENÉ, Daniel   +5 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

ANTITUMOR ACTIVITY OF CRATEVA MAGNA IN TRANSPLANTABLE TUMOR MODELS IN MICE: ANTITUMOR ACTIVITY OF CRATEAVA MAGNA [PDF]

, 2019
Objective: The present study aims to evaluate the anticancer and immunomodulatory activity of both the alcoholic and aqueous extracts of Crateva magna (ALCM and AQCM) in solid tumor model and ascites tumor model in mice.
SANTHEPETE N MANJULA, ANKITA DEEP, SINDHU R, KENGANORA MRUTHUNJAYA   +3 more
core  

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Otimização das condições de cultivo de Polyporus tricholoma Mont. visando a produção de substâncias antibacterianas [PDF]

, 2005
Dissertação (mestrado) - Universidade Federal de Santa Catarina. Programa de Pós-Graduação em Biotecnologia.O aumento crescente de bactérias resistentes devido a múltiplos fatores incentiva à pesquisa de novas substâncias antibacterianas.
Vieira, Gladys Rosane Thomé
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