Results 121 to 130 of about 66,224 (151)

Identification and Characterization of Strychnine-Binding Peptides Using Phage-Display Screening.

Protein Peptide Letters, 2017
BACKGROUND In drug development, phage display is a high-throughput method for identifying the specific cellular targets of drugs. However, insoluble small chemicals remain intractable to this technique because of the difficulty of presenting molecules to
Fang Zhang, Min Wang, Zheng Qiu, Xiao-Meng Wang, Chunlei Xu, Xia Zhang   +5 more
semanticscholar   +1 more source

Abstract 1944: High-throughput fluorescence-based assay for screening of Arginase I inhibitors for cancer immunotherapy

Experimental and Molecular Therapeutics, 2018
Arginase I (ArgI) is an important small molecule drug target in cancer immunotherapy. Arg1 converts L-arginine into L-ornithine and urea. Recruitment of ArgI-expressing myeloid-derived suppressor cells (MSDCs) at a tumor site results in the depletion of ...
Y. Grobben, J. Uitdehaag, N. Willemsen-Seegers, W. Tabak, Martine B. W. Prinsen, Suzanne J.C. van Gerwen, J. V. Groningen, J. Friesen, Helma Rutjes, J. Man, R. Buijsman, G. Zaman   +11 more
semanticscholar   +1 more source

Computational studies of epidermal growth factor receptor: docking reliability, three-dimensional quantitative structure-activity relationship analysis, and virtual screening studies.

Journal of Medicinal Chemistry, 2009
An aberrant activity of the epidermal growth factor receptor (EGFR) has been shown to be related to many human cancers, such as breast and liver cancers, thus making EGFR an attractive target for antitumor drug discovery.
C. La Motta, S. Sartini, T. Tuccinardi, E. Nerini, F. Da Settimo, A. Martinelli   +5 more
semanticscholar   +1 more source

Discovery of New E‐Selectin Inhibitors by Virtual Screening, Fluorescence Binding Assays, and STD NMR Experiments

ChemMedChem, 2016
Pabla A. Barra, V. Jiménez, J. Gavín, A. Daranas, J. Alderete   +4 more
semanticscholar   +1 more source

A natural products approach to drug discovery: probing modes of action of antitumor agents by genome-scale cDNA library screening.

Methods in molecular biology, 2009
H. Luesch, P. Abreu
semanticscholar   +1 more source

Design, Synthesis, and Cytotoxic Screening of New Quinoline Derivatives over MCF-7 Breast Cancer Cell Line

Russian journal of bioorganic chemistry, 2020
I. Zaki, A. M. Imam
semanticscholar   +1 more source

Apoptosis-based drug screening and detection of selective toxicity to cancer cells

Anti-Cancer Drugs, 2003
O. Frankfurt, A. Krishan
semanticscholar   +1 more source

Cervical cancer screening for individuals at average risk: 2020 guideline update from the American Cancer Society

Ca-A Cancer Journal for Clinicians, 2020
Carmen E Guerra, Kevin C Oeffinger, Louise C Walter   +2 more
exaly  

Antitumor activity of amidino-substituted benzimidazole and benzimidazo[1,2-a]quinoline derivatives tested in 2D and 3D cell culture systems

Journal of Enzyme Inhibition and Medicinal Chemistry, 2016
K. Brajša, I. Vujasinović, Dubravko Jelić, Marija Trzun, Ivo Zlatar, G. Karminski-Zamola,, M. Hranjec   +6 more
semanticscholar   +1 more source

[Application of renal subcapsular assay to human malignant glioma--a new screening method in vivo for antitumoral drugs].

Gan to kagaku ryoho. Cancer & chemotherapy, 1985
H, Hamada, T, Asakura, K, Matsuda, W, Wechsler, K, Rathmer   +4 more
openaire   +1 more source