Results 121 to 130 of about 37,916 (265)
Avaliação toxicológica de nanopartículas compostas de dióxido de titânio, superparamagnéticas de óxido de ferro e de poliuretano in vitro, in vivo, ex vivo e in silico [PDF]
, 2015 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2015.A nanotecnologia envolve a compreensão e manipulação da matéria em escala nanométrica, em que os ...
Silva, Adny Henrique
core
Cell Communication and SignalingDrug resistance poses a significant challenge in hepatocellular carcinoma (HCC) treatment. In this study, we aimed to assess the efficacy of celecoxib against HCC and uncover the underlying mechanism.
Zhe Hou +9 more
doaj +1 more source
Prognostic value and therapeutic potential of the cuproptosis-related gene LOXL2 in thyroid cancer
Translational OncologyBackground: Cuproptosis, a copper-dependent form of programmed cell death, has been implicated in the progression of various cancers. However, the role of LOXL2 - a cuproptosis-related gene (CRG) - and its prognostic value in thyroid cancer (THCA) remain
Yu Liu +11 more
doaj +1 more source
From Payload‐First Toward Dual‐Mechanism Antibody–Drug Conjugates
Advanced Materials, EarlyView.Conjugation converts potent antibodies into underexposed carriers. This perspective defines the antibody exposure deficit and maps a mechanism‐first design space from payload‐first to antibody‐first ADC architectures, integrating DAR, linker chemistry, and Fc engineering to guide rational design of constructs that balance targeted cytotoxicity with ...
Xavier Pivot +3 more
wiley +1 more source
Topoisomerase-II mediated biochemical mapping of centromeres and nitroreductase mediated drug metabolism in Trypanosomatids [PDF]
, 2012 PhDThe protozoan parasites Trypanosoma cruzi and Trypanosoma brucei are the causative agents of Chagas disease and Human African sleeping sickness respectively.
Bot, Christopher
core
Journal of Experimental & Clinical Cancer ResearchBackground Anti-HER2 therapies, including the HER2 antibody–drug conjugates (ADCs) trastuzumab emtansine (T-DM1) and trastuzumab deruxtecan (T-DXd), have led to improved survival outcomes in patients with HER2-overexpressing (HER2+) metastatic breast ...
Jangsoon Lee +16 more
doaj +1 more source
Advanced Materials Interfaces, EarlyView.Therapeutic nano‐drug delivery systems interact with cellular mitochondria in a multitude of ways. While the complexity of such interactions disrupts the mitochondrial electron transport chain and increases reactive oxygen species production, thereby contributing to nanoparticle toxicity, they also present unique theranostic opportunities in diseases ...
Sourav Bhattacharjee
wiley +1 more source
Avaliação das atividades cicatrizante e antitumoral de extratos provenientes da casca de banana cultivar Prata Anã (Musa spp) [PDF]
, 2012 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biotecnologia, Florianópolis, 2010Na medicina popular brasileira, a casca de banana tem um histórico de uso na cura de lesões por
Pereira, Aline
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In Silico Identification of DNMT Inhibitors for the Treatment of Glioblastoma
International Journal of Translational MedicineBackground/Objectives: Gliomas are the most common tumours of the central nervous system (CNS), classified into grades I to IV based on their malignancy. Genetic and epigenetic alterations play a crucial role in glioma progression. DNA methyltransferases
Meyrem Osum +2 more
doaj +1 more source