Results 211 to 220 of about 37,916 (265)

Corrigendum for Figure and author affiliation corrections in previously published articles of <i>Bioactive Materials</i>. [PDF]

Bioact Mater
europepmc   +1 more source

Target-Centric Multiplexed Screening of an Herbal Extract Identifies a Novel Dual A_2A/A_2B Receptor Antagonist for Cancer Immunotherapy. [PDF]

ACS Cent Sci
Liu H, Yang X, Xu J, Wang Y, Zhao Z, Quan K, Gao A, Wang Y, Wu J, Li F, Zhang Z, Ma Y, Weng Y, Chen Y, Sun L, Song G, Shan Y, Chai X, Zhang B, Lu W, Shui W.   +20 more
europepmc   +1 more source

SSR4 sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science, EarlyView.
SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
wiley   +1 more source

Mechanism of <i>Inonotus hispidus</i> in suppressing renal cell carcinoma proliferation via regulation of the PI3K/AKT/mTOR pathway. [PDF]

Front Pharmacol
Wei Y, Liu H, Wang A, Huang Q, Liu R, Yu H, Song Y, Hu R, Li X.   +8 more
europepmc   +1 more source

NAT10‐Mediated ac4C Modification of circANKRD12 Reprograms the Tumor Microenvironment

Advanced Science, EarlyView.
NAT10‐dependent acetylation of circANKRD12 drives translation of the circANKRD12_354aa protein, which binds HDAC2 to stabilize c‐Myc via deubiquitination, promoting multiple myeloma (MM) cell proliferation. Concurrently, the circANKRD12‐HDAC2 axis suppresses H3ac‐mediated transcription of IFN‐γ, TNF‐α, and GZMB in NK cells, leading to NK cell ...
Jiale Zhang, Hui Shi, Chen Wang, Zihao Liu, Lianxin Zhou, Xinyu Lv, Mengjie Guo, Ye Yang, Chunyan Gu   +8 more
wiley   +1 more source

Development of a Human IgG1 Monoclonal Antibody Targeting Transferrin Receptor 1 for Antitumor Drug Delivery. [PDF]

Antibodies (Basel)
Ji T, Zong Z, Gong N, Yan M, Chen S.
europepmc   +1 more source

PGK1 Suppresses CD8+ T Cell‐Mediated Antitumor Immunity Through CCL2/CCR2/Tumor‐Associated Macrophages Axis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
PGK1 in tumor cells upregulates CCL2 expression through activation of the AKT/GSK‐3β/β‐catenin signaling axis, thereby promoting the recruitment and M2 polarization of TAMs and ultimately impairing the infiltration and activation of CD8+ T cells within the HCC tumor microenvironment. ABSTRACT Patients with advanced hepatocellular carcinoma (HCC) have a
Xi Liu, Jianpeng Liu, Zhihao Zhang, Xizhi Yu, Junjie Qian, Limin Ding, Qinchuan Wu, Zhe Yang, Xing‐Yu Luo, Xinjiang Ding, Rong Su, Xiaobo Yu, Yiting Qiao, Shengyong Yin, Haiyang Xie, Lin Zhou, Yuanxing Liu, Shusen Zheng   +17 more
wiley   +1 more source

Discovery and Structural Optimization of BRD4-Selective Monovalent Direct Degraders. [PDF]

ACS Med Chem Lett
Leriche G, Barmare F, Toth JI, Jamborcic A, Kampert TL, Steadman K, Yang L, Fish S, Daniele E, McCarrick M, Kallel EA, Li X, Thompson PA, Parker GS, Freeman-Cook K, Bailey S.   +15 more
europepmc   +1 more source

Topology‐Aware Deep Learning on Higher‐Order Structures for Drug Response Prediction

Advanced Science, EarlyView.
We present TopDr, a topology‐aware deep learning framework that encodes both drugs and cell lines as multiscale simplicial complexes, capturing interactions at the 0‐, 1‐, and 2‐simplex levels. By jointly integrating local higher‐order neighborhoods and global topological structures, TopDr generates enriched representations for sensitivity prediction ...
Cong Shen, Guancen Lin, Chuan‐Shen Hu, Yong Wang   +3 more
wiley   +1 more source

Therapeutic targeting of adhesion GPCRs: a status update and future potential. [PDF]

Expert Opin Drug Discov
Stillwell JD, Elmi MA, Parag RR, Van Meir EG.   +3 more
europepmc   +1 more source