Results 81 to 90 of about 3,507,735 (293)

A novel decatenation assay for DNA topoisomerases using a singly-linked catenated substrate

BioTechniques, 2020
Decatenation is a crucial in vivo reaction of DNA topoisomerases in DNA replication and is frequently used in in vitro drug screening. Usually this reaction is monitored using kinetoplast DNA as a substrate, although this assay has several limitations ...
Nidda F Waraich, Shruti Jain, Sean D Colloms, William Marshall Stark, Nicolas P Burton, Anthony Maxwell   +5 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Antiprotozoal activity profiling of approved drugs : a starting point toward drug repositioning [PDF]

, 2015
Neglected tropical diseases cause significant morbidity and mortality and are a source of poverty in endemic countries. Only a few drugs are available to treat diseases such as leishmaniasis, Chagas' disease, human African trypanosomiasis and malaria ...
Leela Pavan Tadoori, Leela Pavan Tadoori (782938), Marcel Kaiser, Pascal Mäser, Jean-Robert Ioset (115415), Tadoori, Leela Pavan, Marcel Kaiser (41510), Ioset, Jean-Robert, Mäser, Pascal, Kaiser, Marcel, Brun, Reto, Pascal Mäser (87895), Jean-Robert Ioset, Reto Brun, Reto Brun (41511)   +14 more
core   +2 more sources

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

Establishment and application of unbiased in vitro drug screening assays for the identification of compounds against Echinococcus granulosus sensu stricto. [PDF]

PLoS Negl Trop Dis, 2023
Kaethner M, Preza M, Kaempfer T, Zumstein P, Tamponi C, Varcasia A, Hemphill A, Brehm K, Lundström-Stadelmann B.   +8 more
europepmc   +1 more source

A kinetic assay for non‐automated drug screening

The FASEB Journal, 2018
A non‐automated kinetic assay has been used in this laboratory to screen reagents that unclump fixed yeast, a model for unclumping human cancer cells, human blood cells and pathogens (FASEB J, 26:62ab; 28:234ab; 29:65ab; 31:539ab). Fixed yeast is the material of choice because its surface properties are similar to live cells without unknowns associated
Gregory C. Zem, A Chimayan, V Aleksanyan, J Gordon, F Gomez, A Seyedroudbari, J Chang, T Botello, N Tan, D Arefin, D Tobar, A Khachekian, L Gama, E Durodola, J Batty, C Plascencia, L Barillas, A Roverud, S Kreuz, L Sarkisyan, F Lee, J Munoz, L Reque, V Abed, L Kinog, SB Oppenheimer   +25 more
openaire   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A tumour-spheroid manufacturing and cryopreservation process that yields a highly reproducible product ready for direct use in drug screening assays. [PDF]

J R Soc Interface, 2023
Shajib MS, Futrega K, Davies AM, Franco RAG, McKenna E, Guillesser B, Klein TJ, Crawford RW, Doran MR.   +8 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source