Results 151 to 160 of about 634,895 (315)

Enhancing transporter activity in heterologous expression systems with SAHA: a 2500‐times more potent and odorless alternative to butyrate

FEBS Open Bio, EarlyView.
Heterologous expression of membrane transporters in cultured cells is essential for functional characterization, but is sometimes limited by low activity. Our study compares the HDAC inhibitors butyrate, VPA and SAHA to enhance transport activity. We propose to replace butyrate by SAHA: it is equally effective, devoid of repulsive odor, costs less, and
Svenja Flögel, Maurice Tust, Samira Boussettaoui, Dietmar Fischer, Dirk Gründemann   +4 more
wiley   +1 more source

THE IMPORTANCE OF CHROMATOGRAPHICALLY PURIFIED EXCIPIENTS

Разработка и регистрация лекарственных средств, 2019
In the present work critical importance and benefits of Super Refined excipients for drug stability, integrity and safety are described. It was shown, that impurities can disrupt API and cause cell irritation.
G. J. Rizzo, K. H. Chen
doaj  

Prediction of stability of drugs. III. Application of Weibull probability paper to prediction of stability.

, 1975
NAOYA OKUSA
openalex   +2 more sources

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Multi-access drug delivery network and stability

International Journal of Nanomedicine, 2011
S Mitatha1, N Moongfangklang1, MA Jalil2, N Suwanpayak3, J Ali4, PP Yupapin31Hybrid Computing Research Laboratory, Faculty of Engineering, King Mongkut’s Institute of Technology Ladkrabang, Bangkok, Thailand; 2Ibnu Sina Institute of Fundamental
Ali J, Yupapin PP, Mitatha S, Moongfangklang N, Jalil MA, Suwanpayak N   +5 more
doaj  

Studies on the Stability of Drugs. XXII. : Stability of Benzothiadiazines. (12). Studies on the Hydrolysis Mechanism of Chlorothiazide

, 1972
YUZO MIZUKAMI, Tsukinaka Yamana
openalex   +2 more sources

Investigations of the effect of the lipid matrix on drug entrapment, in vitro release, and physical stability of olanzapine-loaded solid lipid nanoparticles [PDF]

, 2007
K. Vivek, Harivardhan Reddy, Ramachandra S. R. Murthy   +2 more
openalex   +1 more source

Hydrophobicity causes anomalous migration of cystine/glutamate antiporter SLC7A11 in SDS‐PAGE with low acrylamide concentration

FEBS Open Bio, EarlyView.
SLC7A11 frequently migrates faster in SDS‐PAGE. The present study found that the high hydrophobicity of SLC7A11 causes its anomalous migration in SDS‐PAGE with a low concentration of acrylamide gel. Replacing isoleucine with asparagine reduced hydrophobicity and restored its normal migration at 55 kDa, revealing the role of hydrophobicity and gel ...
Nsengiyumva Emmanuel, Qian He, Yixin Kang, Dianbao Zhang, Min Gao, Minglin Wang, Kexin Fan, Jingwen Xiong, Shaobo Wu, Botao Fa, Zhengtao Xiao, Yingfang Niu, Jun Yao, Yilei Zhang   +13 more
wiley   +1 more source

Decomposition and Stabilization of Drugs. XII. Structure and Stability of Aminoalkylesters. (4)

, 1975
KAZUO KIGASAWA, Noriko Hasegawa, HIDEAKI OHTANI, NORIKO OHTAKE, SOJI AWAZU   +4 more
openalex   +2 more sources

The Modulation of Transthyretin Tetramer Stability by Cysteine 10 Adducts and the Drug Diflunisal [PDF]

, 2008
Jonathan S. Kingsbury, Thomas M. Laue, Elena S. Klimtchuk, Roger Théberge, Catherine E. Costello, Lawreen H. Connors   +5 more
openalex   +1 more source