Results 161 to 170 of about 8,056,631 (393)

THE IMPORTANCE OF CHROMATOGRAPHICALLY PURIFIED EXCIPIENTS

Разработка и регистрация лекарственных средств, 2019
In the present work critical importance and benefits of Super Refined excipients for drug stability, integrity and safety are described. It was shown, that impurities can disrupt API and cause cell irritation.
G. J. Rizzo, K. H. Chen
doaj  

Long-Term Stability of Glycopyrrolate Oral Solution Galenic Compound at Different Storage Conditions

Pharmaceutics
Glycopyrrolate is a competitive muscarinic receptor antagonist used in the treatment of sialorrhea, especially in pediatrics. Degradation research was conducted to better understand the stability of the active pharmaceutical ingredient (API).
Barbara Bellich, Martina Franzin, Debora Curci, Mario Cirino, Alessandra Maestro, Giada Bennati, Gabriele Stocco, Gianpiero Adami, Natalia Maximova, Domenico Leonardo Grasso, Egidio Barbi, Davide Zanon   +11 more
doaj   +1 more source

Prediction of the changes in drug dissolution from an immediate-release tablet containing two active pharmaceutical ingredients using an accelerated stability assessment program (ASAPprime®) [PDF]

, 2016
Hanlin Li, David Nadig, Andrew Kuzmission, Christopher M. Riley   +3 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

The Minnesota Supportive Housing and Managed Care Pilot: Evaluation Summary [PDF]

, 2010
Summarizes an evaluation of a pilot program to end homelessness for those with complex needs by providing housing and intensive supports. Examines outcomes including housing stability, mental health, and alcohol and/or drug use, as well as service ...

core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Atomic Force Microscopy-Based Screening of Drug-Excipient Miscibility and Stability of Solid Dispersions [PDF]

, 2018
: Purpose: Development of a method to assess the drug/polymer miscibility and stability of solid dispersions using a melt-based mixing method. Methods: Amorphous fractured films are prepared and characterized with Raman Microscopy in combination with ...
Alsenz, Jochem, Engel, Andreas, Grassmann, Olaf, Jacob, Laurence, Kindt, Johannes, Lauer, Matthias, Page, Susanne, Siam, Monira, Tardio, Joseph   +8 more
core  

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

PEG Branched Polymer for Functionalization of Nanomaterials with Ultralong Blood Circulation

, 2009
Nanomaterials have been actively pursued for biological and medical applications in recent years. Here, we report the synthesis of several new poly(ethylene glycol) grafted branched-polymers for functionalization of various nanomaterials including carbon
Adams M. L., Ashiuchi M., Bruchez M., Chan W. C. W., Chatterjee T., Chen R. J., Chen Z., Cheng Y., Cognet L., Dieckmann G. R., Dubertret B., Fan H. Y., Gao M. Y., Gerion D., Han G., Huff T. B., Ipe B. I., Jiang W., Kam N. W. S., Kam N. W. S., Kanaras A. G., Karajanagi S. S., Kogan M. J., Kryachko E. S., Lin Wang W. Z., Liu W. H., Liu Z., Liu Z., LizMarzan L. M., Markowitz M. A., Maubach G., Mulder W. J. M., Nakayama-Ratchford N., Nam J. M., Nath N., Numata M., Oyelere A. K., O’Connell M. J., Paciotti G. F., Parveen S., Pinaud F., Porta F., Richard C., Schultz S., Selvan S. T., Sinani V. A., Sinha N., Sohn B. H., Sonnichsen C., Thaxton C. S., Tong L., Wang D., Welsher K., Williams K. A., Xiaoming Sun Z. L., Yang S. T., Zhelev Z., Zheng M., Zheng M.   +58 more
core   +1 more source