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Supramolecularly stabilized diabetes drugs
Nature Biomedical Engineering, 2020The stabilization of co-administered insulin and pramlintide with cucurbit[7]uril-conjugated poly(ethylene glycol) in diabetic pigs enhances the overlap of their therapeutic windows.
Kim, Henriksen, Morten A, Karsdal
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Antiepileptic Drugs and Mood Stability
Clinical EEG and Neuroscience, 2007This paper will discuss different definitions of the term “mood stabilizer” and highlight in detail the antiepileptic drugs carbamazepine, valproate and lamotrigine with respect to their relative strengths in stabilizing mood in bipolar patients. These drugs are heterogeneous in their mechanisms of action and in their efficacy to stabilize patients ...
Benedikt, Amann +3 more
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2022
Stability of drug is the capacity of the pharmaceutical dosage form to maintain the chemical, physical, microbial and therapeutic properties during the time of storage and usage by the patient. Stability studies are done to determine the expiry date of products and to choose formulations and container closure techniques that are appropriate in terms of
null Ashu, Kavita Sapra
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Stability of drug is the capacity of the pharmaceutical dosage form to maintain the chemical, physical, microbial and therapeutic properties during the time of storage and usage by the patient. Stability studies are done to determine the expiry date of products and to choose formulations and container closure techniques that are appropriate in terms of
null Ashu, Kavita Sapra
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2023
The chemical stability of drugs plays a pivotal role in the pharmaceutical industry, impacting drug development, manufacturing, storage, and ultimately, patient safety. This abstract explores the key aspects of chemical stability, emphasizing its significance in drug formulation and quality control.
Sandeep Mukati +3 more
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The chemical stability of drugs plays a pivotal role in the pharmaceutical industry, impacting drug development, manufacturing, storage, and ultimately, patient safety. This abstract explores the key aspects of chemical stability, emphasizing its significance in drug formulation and quality control.
Sandeep Mukati +3 more
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Stability of nanosuspensions in drug delivery
Journal of Controlled Release, 2013Nanosuspensions are nanosized colloidal dispersion systems that are stabilized by surfactants and/or polymers. Because nanosizing results in the creation of new interfaces and in a positive Gibbs free energy change, nanosuspensions are thermodynamically unstable systems with a tendency toward agglomeration or crystal growth.
Yancai Wang +4 more
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Stability of Drug Additives to Peritoneal Dialysate
Peritoneal Dialysis International, 1995 Click on the Resource Link to access the article (may not be free).OBJECTIVE: The primary literature was reviewed to determine the stability of drug additives in peritoneal dialysis solutions.DATA SOURCES: A MEDLINE search and retrieval, covering the ...
George R Bailie, Michael P Kane
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2020
This chapter evaluates drug stability, which is a vital aspect of drug development. The types of stability that will need to be examined are physical stability and chemical stability. In particular, at an early stage, it is important to determine the mechanism of any instability, the reaction kinetics involved in any instability, and the factors that ...
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This chapter evaluates drug stability, which is a vital aspect of drug development. The types of stability that will need to be examined are physical stability and chemical stability. In particular, at an early stage, it is important to determine the mechanism of any instability, the reaction kinetics involved in any instability, and the factors that ...
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Guidelines for Drug Stability and Stability Testing
2020Stability studies are pivotal necessities for ensuring safety, potency, and quality of drug products throughout their shelf-life. These guarantee that pharmaceutical products will remain stable and effective under the recommended storage conditions and are considered as prerequisite for approval of any pharmaceutical product.
Kamran Haider +3 more
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Determination of the Stability of Drugs in Plasma
Current Protocols in Pharmacology, 2002AbstractIn order for a drug to be effective, enough of the active form must reach the target to elicit the desired effect. The first‐pass effect for drugs taken orally is well known but the metabolism of drugs in plasma must also be considered during the drug discovery and development process.
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